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Showing 1 to 20 of 68 for “"Benzimidazole"”.
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Benzimidazole-Based Fluorophores and Noncovalent Organic Frameworks
… a simpler "half cruciform" architecture with benzimidazole core, namely L-shaped benzimidazole fluorophores. These fluorophores showed separate frontier molecular orbitals in donor–acceptor systems, similar to benzobisoxazole cruciforms. They display change in their fluorescent emission upon …
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Exploring poly (2, 5) benzimidazole enhanced with carbon nanotubes for space applications
This work explores using polymeric materials for space radiation shielding in low-earth orbit. Shielding against radiation is essential on any space mission. Low atomic number materials, such as hydrogen, have shown to be effective in shielding ionising radiation. However, compared to metallic …
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Synthesis and investigation of benzimidazole and carbazole ß-haematin inhibiting scaffolds with antimalarial activity
… project with two different scaffolds, namely benzimidazole and carbazole indole. In order to preselect benzimidazole derivatives for synthesis, Discovery Studio and Pipeline Pilot where used in tandem to enumerate 325 728 in silico compounds. These were filtered according to predicted …
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Development of aminoquinoline-benzimidazole hybrids and their organometallic complexes as antimicrobial agents against Plasmodium falciparum and Mycobacterium tuberculosis
… of new organic and ferrocenyl aminoquinoline-benzimidazole hybrid compounds, as well as the corresponding Platinum Group Metal (PGM)-containing complexes. The compounds were screened for their activity against Plasmodium falciparum, and for their cytotoxicity against the Chinese hamster …
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The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents
… of lanthanide chelators based on DO3A bearing a benzimidazole or a benzyl derivative that can act as both a chromophore unit and a linking group for conjugation that has the functionality to couple to an optical dye (either rhodamine or BODIPY derivatives) is discussed.A series of lanthanide …
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Isolation and characterization of African marine natural products and repositioning of the natural product antibiotic fusidic acid and privileged benzimidazole scaffold for tuberculosis and malaria
… concentration tested of 5 µM. The privileged benzimidazole scaffold has afforded antiviral, antiulcer, antimicrobial, antitumor, antihypertensive, anti-inflammatory and antihistaminic clinical chemotherapeutic agents. A limited number of studies describing the utility of benzimidazoles as …
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Synthesis and biological evaluation of trimeric 2,5-disubstituted benzimidazoles and related trinuclear ruthenium(II) organometallic complexes
… and characterize a series of 2,5-disubstituted benzimidazole-based trimeric compounds and related trinuclear complexes bearing ruthenium(II) metal centers at the periphery. All of the synthesized compounds were screened for their in vitro cytotoxicity against the MCF-7 and MDA-MB-231 breast …
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Design and Synthesis of Benzimidazoles as CDK5 Inhibitors and Progress toward the Total Synthesis of Tubulysin D
… the design and synthesis of 1,4,6-trisubstituted benzimidazoles as CDK5 inhibitors and the progress toward the total synthesis of tubulysin D.</p><p> Tubulysin is a natural product with potential anti-cancer activity. The two gamma-amino acids in the Tuv and Tup fragments of tubulysin were …
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Synthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents. An investigation into the synthesis of substituted benzimidazoles and their evaluation in vitro for antimicrobial activity.
… of this project was to synthesise derivatives of benzimidazole, and then assesses their antimicrobial activities in vitro by using disc (well) diffusion and MICs tests. A total of 69 benzimidazole derivatives, with substituents at positions 1, 2, and 5, were synthesised, characterised and tested …
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An HPLC method for simultaneous determination of residual benomyl and MBC on apple foliage without cleanup
… identify benamyl (methyl 1- (butylcarbamoyl)-2-benzimidazole carbamate) and MBC (methyl 2-benzimidazole carbamat~ residues on apple leaves without cleanup. Sample leaves are freeze dried in a Mason jar and residues are then extracted by tumbling them in chloroform containing 5,000 microgram per …
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Design and Synthesis of Novel Benzimidazoles and Aminothiazoles as Small Molecule Inhibitors of CDK5/p25
… 1UNL), eight series of novel compounds with a benzimidazole core were designed, synthesized and tested as inhibitors of CDK5/p25. An efficient synthesis of trisubtituted benzimidazoles was developed to explore the SAR at the 1-, 4-, and 6- positions of the benzimidazole core. X-ray crystal …
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Synthesis of Mononuclear Transition Metal Complexes and their Applications as Catalysts for Ethylene Polymerization
… zirconium and vanadium complexes with bis(benzimidazole)s, bis(benzothiazole)s and bis(benzoxazole)s is a main objective of this study. Their catalytic performance towards ethylene polymerization reactions was also studied. The ligand systems mentioned above were synthesized via …
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Synthesis and antiplasmodial structure-activity relationships for some novel 4-aminoquinolines and 5-chlorobenzimidazoles
… accumulation in the parasite. In addition, the benzimidazole nucleus, which has similar dipolar character to 4-aminoquinoline nucleus, was investigated as alternative template for potential antimalarials. This involved the synthesis of the chloroquine-like analogues …
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Reactions of Congo Red and Azo Dye Congeners With Formaldehyde
… to form multiple products, including a colorless benzimidazole form previously characterized and an unidentified yellow compound. Congeners equivalent to half of the symmetrical Congo red molecule and related structures were synthesized to simplify reaction separation and analysis. Because the …
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Advanced systems for the rapid detection of anthelmintic drugs in food
… first screening assay was developed to detect 11 benzimidazole carbamates in milk and liver. In bovine milk the assay showed a limit of detection (LOD) of 2.7 μg kg-1 and a detection capability (CCβ) of 5 μg kg-1. Analyte recovery was in the range 81 to 116% and the assay was found to be fit for …
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The supramolecular derivatisation of pharmaceutically relevant compounds via co-crystallization and cyclodextrin inclusion complexation
… (a) three drug leads, namely pyrido[1,2-a]benzimidazole derivatives [displaying activity against schistosomiasis (bilharzia)], (b) two steroidal compounds, namely -estradiol (used for hormonal therapy and treatment of breast and prostate cancer), and progesterone (used for hormonal …
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Structure-activity relationship studies of 2-phenylbenzimidazoles and related organometallic complexes as antiplasmodial agents
… resistant strains in particular. In this regard, benzimidazoles have been identified as promising potential drug candidates, displaying potent antiplasmodial activity. Furthermore, benzimidazoles can be chemically transformed into metal-containing organometallic complexes that elevate generally …
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Studies on Organophosphorus Catalyzed C(SP³)–H Amination for the Synthesis of Benzimidazoles
… amination has been realized for (dihydro)benzimidazole synthesis. This work reports: (1) optimization of organophosphorus-catalyzed C(sp³)–H functionalization; (2) scope studies to benzimidazoles by in situ oxidation of the corresponding dihydrobenzimidazole; and (3) insight into the …
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