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Showing 1 to 2 of 2 for “"Bendamustine"”.
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Actions of Pi3K-Delta Inhibitor, Idelalisib, and Its Combination With Bendamustine In Chronic Lymphocytic Leukemia
… for DNA damage and repair response.</p> <p>Bendamustine is a FDA approved alkylating agent for CLL therapy. We hypothesized that idelalisib-mediated decline in Mcl-1and bendamustine-induced DNA damage will sensitize B-CLL cells and this mechanism-based combination will lead to a synergistic …
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Pim Kinase Inhibition: Single Agent and Combination Approaches In B-Cell Lymphoma
… a combination strategy using SGI-1776 with bendamustine, an FDA-approved DNA-damaging alkylating agent for treating non-Hodgkin’s lymphoma. We hypothesized this combination will enhance SGI-1776-induced transcription and translation inhibition, while promoting bendamustine-triggered DNA …