Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Belimumab"”.
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B cell therapy in ANCA-associated vasculitis
… trial (a mechanistic study of rituximab plus belimumab versus rituximab plus placebo in AAV) samples to evaluate the early pharmacodynamic effects of BAFF antagonism with belimumab on B cells and B cell subsets in patients with active AAV. A combination of flow cytometry and scRNA-seq was used …
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Investigation of novel therapeutic strategies in B cell and antibody mediated disease
… I firstly explored the therapeutic potential of belimumab, an anti-BLyS antibody, in an experimental medicine study in kidney transplant recipients. The rationale for this study was based on published studies showing that B cells activate alloreactive T cells and secrete human leukocyte antigen …
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The Role of Histone Deacetylase 6 Inhibition on Systemic Lupus Erythematosus
… In the past 60 years, only one new drug, belimumab was approved for lupus disease with modest efficacy in clinic and not approved for patients suffering for nephritis. Therefore, it is urgent to develop new treatments to replace or reduce the use of current ones. Histone deacetylase 6 …