Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Behavioral sensitization"”.
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Pharmacokinetic and neurochemical correlates of context-dependent behavioral sensitization
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Role of Dopamine of Nucleus Accumbens In Behavioral Sensitization to Methylphenidate
Behavioral sensitization is defined as the subsequent augmentation of the locomotor response to a drug following repeated administrations of the drug. It is believed to occur due to alterations in the motive circuit in the brain by stressors, central nervous system stimulants, and similar stimuli. …
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Activity-dependent mitochondrial signaling drives GLR-1 dynamics and behavioral sensitization in C. elegans
… partners to establish a long-term reversal sensitization protocol. When combined with mitochondria and GLR-1 readouts, we found that postsynaptic, activity-dependent mitochondrial ROS production is necessary and sufficient for sensitization. This increased redox signaling results in elevated …
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IMPORTANCE OF THE D2 RECEPTOR FOR ONE- AND MULTI-TRIAL PSYCHOSTIMULANT-INDUCED BEHAVIORAL SENSITIZATION IN PREWEANLING RATS
… mechanisms mediating one-trial and multi-trial behavioral sensitization during early ontogeny are poorly understood. The purpose of this thesis was to assess the importance of D2-like receptors for the induction of cocaine- and methamphetamine-induced one-trial and multi-trial behavioral …
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THE IMPORTANCE OF SEROTONERGIC AND ADRENERGIC RECEPTORS FOR THE INDUCTION AND EXPRESSION OF ONE-TRIAL COCAINE-INDUCED BEHAVIORAL SENSITIZATION
<p>Addiction is a complex process in which behavioral sensitization may be an important component. While the behavioral effects of sensitization are well established, the intricate neurobiology of the phenomenon is still largely unknown. Dopamine systems mediate the induction of behavioral …
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Understanding the neuroadaptations underlying the effects of (+)-methylenedioxymethamphetamine [(+)-MDMA; ecstasy]: Implications for the serotonin 5-HT2A receptor and its binding partners
… (MDMA, “ecstasy”) induces “behavioral sensitization,” an enhancement of its behavioral effects. The molecular changes underlying behavioral sensitization may be linked to neuropsychological sequelae (e.g., depression, anxiety) seen upon withdrawal from MDMA exposure. …
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Ventral Tegmental Area Neuronal Responses to Methylphenidate Correlated to Behavioral Responses of Adolescent and Adult Rats
… psychostimulant action thought to be involved in behavioral sensitization. The aim of the this study was to first determine if there are differences in neuronal responses between individuals, with respect to neuronal firing patterns in the ventral tegmental area (VTA), and whether these …
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Behavioral Responses to Methylphenidate: Correlations With Neuronal Activity In The Caudate Nucleus
… chronic responses to the same dose of MPH. Behavioral and caudate nucleus (CN) neuronal activity following acute and chronic doses of MPH was assessed by simultaneously recording the behavioral and neuronal activity. The experimental protocol lasted for 10 days using four groups; saline, …
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Serotonin 5-HT<sub/>2C</sub> receptors: Role in (+)-MDMA sensitization and distribution in the ventral tegmental area
… to the development and/or expression of behavioral sensitization. We tested the hypothesis that intermittent exposure to (+)-MDMA or the 5-HT<sub/>2C</sub>R agonist MK 212 results in enhanced (+)-MDMA-evoked locomotor activity (\"behavioral sensitization\") concurrent with decreased …
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The serotonin (5-HT) 2C receptor (5-HT2CR) and its downstream signaling components: Distinct adaptations in cortical circuits associated with cocaine exposure
… Neuronal adaptations underlying this enduring behavioral transformation, known as behavioral sensitization, have been proposed to mediate the incentive motivational effects of cocaine that contribute to increased anxiety, craving and paranoia observed in cocaine addicts. Neuroadaptations in the …
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Role of basic fibroblast growth factor in the development of sensitization to the effects of amphetamine
… responsible for this persistent drug-induced sensitization are unknown, but evidence suggests that neuroadaptations initiated in the cell body region of midbrain dopaminergic neurons and dependent on glutamatergic transmission underlie its development. In this thesis, the hypothesis that basic …
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Repeated amphetamine exposure and the enduring consequences on behavioral and neural plasticity
… locomotor response (i.e., the ability to induce sensitization) and medial PFC (mPFC) firing activity to repeated AMPH treatment. The results suggested that repeated AMPH led to very selective changes in mPFC function when behavioral sensitization was present. Specifically, the magnitude of …
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Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex: Role in Cocaine Sensitization and Addiction
<p>Cocaine sensitization is associated with cocaine-induced hyperexcitability of pyramidal projection neurons within the medial prefrontal cortex (mPFC). Such hyperexcitability presumably results in increased glutamatergic input to reward-affiliated brain regions such as the ventral tegemental area …
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INVESTIGATIONS INTO THE STEREOCHEMICAL AND GLUTAMATERGIC MECHANISMS OF THE "BATH SALTS" SYNTHETIC CATHINONES MEPHEDRONE AND MDPV IN RATS
… We first evaluated MEPH’s ability to produce behavioral sensitization (detailed in Chapter 2), a hallmark behavior of psychostimulants involving repeated, intermittent drug administration, followed by a period of drug abstinence, and a subsequent drug challenge. This evaluation of MEPH’s …
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CYP2D in the Brain Alters Response to Drugs and Neurotoxins
… repeated methamphetamine-induced stereotypy sensitization. Next, to assess the role of human CYP2D6 in brain in vivo, humanized CYP2D6-expressing transgenic mice and wild-type mice were given intracerebroventricular pretreatments with a CYP2D inhibitor. A four-hour inhibitor pretreatment …
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Meccanismo d'azione del Pramipexolo nella terapia della malattia di Parkinson
… investigate the role of PPX (0,05 mg/kg s.c.) in behavioral sensitization, we tested its effect with S33084 pretreatment in levodopa sensitized rats. Second, we assessed the correlation between PPX treatment, Parkinson’s disease and the onset of DA Dysregulation Syndrome on Conditioned Place …
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Estrogen Signaling in Trigeminal Nociception
… which estrogen receptor is required for behavioral sensitization. In order to determine whether GPR30 is present in neurons of the trigeminal ganglion, we performed Western blots for GPR30 on trigeminal ganglion from ovariectomized female Sprague-Dawley rats. Our results show the presence …
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Role of Medial Prefrontal Cortical Group II Metabotropic Glutamate Receptor in the Development of Cocaine Sensitization
… in the development of cocaine sensitization. Initial studies demonstrated that intra-mPFC injection of the mGluR<sub>2/3</sub> receptor agonist, APDC, dose-dependently reduced acute behavioral response to cocaine (0.015-15 nmol/side with significant effects starting at …