Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"Behavioral assays"”.
-
GENETIC DISSECTION OF AVERSION TO ALLYL ISOTHIOCYANATE IN Drosophila melanogaster
… (TRP) Channels, leading to many animal's behavioral aversion to the chemicals the plants produce. The TRPA subfamily, which in mammals has one member (TRPA1) responds to many electrophiles, including allyl isothiocyanate (AITC). Drosophila have four homologs to the mammalian TRPA1: dTRPA1, …
-
Reinforcement and cascade reinforcement in the lucania system: the effects of experimental design, sex, and heterospecific pairings on mate preference
… 2010; Pfennig 2016). This often involves using behavioral assays and metrics to determine conspecific or native mate preference in the laboratory. Despite the importance of using assays and metrics that correctly detect reproductive isolation, studies often do not test whether their experimental …
-
Phenotypic And Electrophysiologic Characterization of a Mouse Model of Fragile X Syndrome
… treatments. In this study, quantitative behavioral assays were used, such as long term fluid licking observations, measurements of ultrasonic vocalizations (USV), and 3D tracking of whisker movements to test Fmr1 KO mice for behavioral deficits compared to their Wild type (WT) …
-
THERE IS NO PLANET B(EE): AN INTEGRATED APPROACH TO UNDERSTANDING DRIVERS OF POTENTIAL DECLINES IN BUMBLEBEE COMMUNITIES
… as we lack information on the physiological and behavioral responses of bumblebee species to climate change and anthropogenic activity. To address this, I performed a series of behavioral and developmental assays with a model bumblebee species Bombus impatiens, alongside analysis of historical …
-
Effects of Farm Management Practices on Pest Slugs and Slug Predators in Field Crops
… a single factor and or a combination of factors. Behavioral assays were performed with a common slug pest, Deroceras laeve, to determine if this species prefers feeding on maize, soybean, daikon radish, crimson clover, rye, or hairy vetch leaf tissue. Our sampling study found that cover crop use …
-
Identification of Peptidyl-prolyl cis/trans isomerases affecting Drosophila circadian rhythms
… melanogaster 5 B. Knockdown fly strains 7 C. Fly behavioral assays 7 D. Plasmids and methods for S2 cell-based assays 8 E. Immunoblotting 8 F. Immunoprecipitation 9 G. Immunohistochemistry 10 H. Quantitative real-time RT–PCR 11 Ⅲ. RESULTS 12 A. PPIases alters Drosophila circadian activity …
-
A streptozotocin-induced model of Alzheimer's disease in mice with wild-type human tau
… deficits and tau pathology, respectively. The behavioral and biochemical findings of the current study provide inconsistent support for the use of an ICV-STZ model in mice expressing human tau, and future studies should employ a battery of behavioral assays to determine if subtle memory …
-
Rod Photoreceptor Regeneration in a Zebrafish Model with Retinitis Pigmentosa
… RNA sequencing, several analysis tools, behavioral assays and oligonucleotides to characterize our zebrafish model and identify the transcription factors necessary for rod photoreceptor regeneration. We show that our zebrafish model has continuous degeneration and regeneration of rod …
-
Chemesthesis in the Earthworm, Lumbricus terrestris: The search for TRP Channels
… using electrophysiological, immunohistochemical, behavioral and cell dissociation/calcium imaging techniques. We obtained responses from segmental nerves to tactile stimulus, 50mM AITC and pH 3.8, 4.0 and 4.2. Some cells in the epidermis displayed positive immunoreactivity for Drosophila and human …
-
Investigating Mechanisms of Co-Occurrence Between Two Similar Specis of Predaceous Diving Beetles (<i>Coleoptera: Dytiscidae</i>) in Temporary Aquatic Habitats
… quantified in the field using artifical ponds. Behavioral assays showed no significant difference in habitat domain or behaviors between species, regardless of intra- or interspecific densities. Mass change due to prey consumption was also not affected by intra- or interspecific densities. In …
-
The Domestic Chick as a Model for Studying Early Social Behaviors and Dopaminergic Dysfunctions in Autism and Fragile X Syndrome
… through an integrated approach combining behavioral assays, immunohistochemistry, molecular analyses, and electrophysiology, this work examines how early neurodevelopmental perturbations shape social behavior and its underlying neurobiological substrates. First, we will describe how …
-
Evaluation of Seizure Threshold as an Early Behavioral Marker of Disease Progression in the Mouse Model of Mucopolysaccharidosis IIIA
… the Barnes maze and novel object recognition behavioral assays did not show a neurological defect earlier than 20 weeks. These results suggest an intact cognitive capacity for the diseased animals. To test whether seizure threshold is altered in diseased animals, mice were administered with …
-
Multi-sensory gamma stimulation ameliorates Alzheimer's-associated pathology and improves cognition
… biochemical and imaging techniques, and behavioral assays to understand the effects of multi-sensory gamma stimulation in AD-like animals. I first show that auditory tone stimulation at 40 Hz (auditory GENUS) can drive gamma frequency neural activity in auditory cortex (AC) and …
-
A Dual Investigation of Questions in Drug Addiction: Exploring the Role of Neuroinflammation in Opioid Withdrawal and A Novel Measure of Reward-Seeking Behavior in Rodents
… in mice as well as 2) introducing a novel behavioral test in order to expand the repertoire of tools available to researchers investigating drug or reward-seeking behaviors in rats. Microglia, the immune cells of the brain have been recently recognized as being important contributors in a …
-
In vivo identification of drug therapeutics for nemaline myopathy
… and genotyping zebrafish lines, conducting behavioral assays with automated activity monitor to assess locomotor function, statistical analysis of the data using GraphPad Prism, and secondary validation screens to confirm drug efficacy. The preliminary screen identified 56 compounds that …
-
Orientation of polyphagous lepidoptera to hostplant kairomones
… (Chapter 1). I then conducted a series of behavioral assays with the navel orangeworm, Amyelois transitella (Walker) (Lepidoptera: Pyralidae), a highly polyphagous species, to determine if larvae of the navel orangeworm respond behaviorally to the same secondary compounds that elicit …
-
Noise-induced cochlear neuronal degeneration and its role in hyperacusis -- and tinnitus-like behavior
… without neuropathy. Crossmodal PPI tests and behavioral assays of anxiety revealed no significant differences among groups, suggesting that the changes in startle-based auditory behavior reflect a neuropathyrelated alteration specifically of auditory neural pathways. Despite significantly …
-
Microbial and Immune Signatures of Stress and Antidepressants Across Sex and Generations
… gut microbial composition, immune signaling, and behavioral phenotypes in a sex-specific and multigenerational manner. To address these questions, we utilized 16S rRNA or whole-genome shotgun metagenomic sequencing in tandem with behavioral assays and multiplex cytokine profiling in rat and mouse …
-
Multiscale Genomic Analysis of the Corticolimbic System: Uncovering the Molecular and Anatomic Substrates of Anxiety-Related Behavior
… basic molecular to higher-order cognitive and behavioral traits. The far-reaching impact that genes have on higher traits is apparent in several neuropsychiatric conditions such as stress and anxiety disorders. Like most, if not all, neural phenotypes, stress, anxiety, and other emotion-related …
-
Glia Are Required For Sensory Neuron Morphology And Function In Caenorhabditis elegans
… profound sensory deficits as determined by behavioral assays, failed to maintain the proper morphology of some modified sensory cilia, and had defects in neuronal uptake of lipophilic dyes. Further, animals lacking glia showed no Ca<sup>2+</sup> responses in the ASH sensory neuron after …
Page 1 of 3