Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"Behavioral Neurobiology"”.
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Elucidation of pharmacologically manipulated responding in the delay discounting task in high alcohol preferring mice
<p>Impulsive behavior is the hallmark of many psychopathologies. Uncovering the neurobiological mechanisms driving impulsivity is paramount in the development of through the delay discounting (DD) task in both human and animal models. The present study is an examination of the predictive validity …
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The Inadequacy of Intracranial Stimulation to the Posterior Hypothalamus to Serve as a Reinforcer for Maze Learning in the Rat
Eighteen, 23 hour food deprived, self-stimulating rats were divided into two groups. One group received 20 ICS pulses as a reward for a correct response in a T-maze while the second group received a food reward. The subjects learned for food over 5 days of 10 massed trials per day, but failed to …
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Testing the efficacy of LSN2463359, a metabotropic glutamate 5 receptor positive allosteric modulator, in animal models of schizophrenia
<p>For many years the dominant theory surrounding the cause of schizophrenia was focused on elevated dopamine levels found in critical areas of the brain. Recently a new theory has emerged pointing to elevated glutamate levels resulting from hypofunction of NMDA receptors and hypoactivity of …
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Ephrin Receptors, AIY Interneuron Physiology, and Behavior
… gene function, cell shape, cell physiology, and behavioral output. Much of the thermosensory and chemosensory information that the nematode receives from its sensory neurons is processed via a pair of interneurons called AIYL and AIYR. In wild-type animals, the AIY cell bodies lie just posterior …
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The Effects of Musical Intervals from Consonant to Dissonant on the Neural Activity of Earthworms
<p>Music is generated through vibrations of a medium creating what is perceived as tone. Two frequencies played simultaneously create intervals, and those ratios of frequencies determine what is consonant and dissonant. Studies have shown a greater neural response in human participants to consonant …
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Cocaine Dependence: The Role of Serotonin Genes In
<p>Animal studies have shown that behavioral responses to cocaine-related cues are altered by serotonergic medications. The effects of pharmacological agents on serotonin receptors 2a (5-HT2A) and 2c (5-HT2C), have yielded results suggesting that selective 5-HT2A antagonists and 5-HT2C agonists …
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The Short and Long-Term Effects of Chronic Ketamine during Adolescence on Object Recognition Memory in Rats
… in a locomotor assessment and subsequently in behavioral testing on the object recognition and location tasks. The animals underwent choice phases where they had to discriminate a novel object or location from a familiar object or location following a 15-minute and 24-hour delay during both …
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THE CHARACTERIZATION OF BEHAVIORAL ABNORMALITIES IN BDNF LOXP TRANSGENIC MICE
… characterization and description of its behavioral phenotype. We utilized a three-stage behavioral protocol which included home cage monitoring observations, open-field, tail suspension, and acoustic PPI to provide a detailed behavioral phenotype for BDNF<sup> lox+/+</sup> mice. Tail …
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tDCS effects on synaptic plasticity and motor skill learning
<p>Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that involves the application of low-intensity constant current to the brain through electrodes placed on the scalp. Its potential to enhance brain function and treat brain-related disorders has led to …
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Role of Dopamine of Nucleus Accumbens In Behavioral Sensitization to Methylphenidate
Behavioral sensitization is defined as the subsequent augmentation of the locomotor response to a drug following repeated administrations of the drug. It is believed to occur due to alterations in the motive circuit in the brain by stressors, central nervous system stimulants, and similar stimuli. …
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Contributions of Reward Identity and Time Prediction Errors to Pavlovian Learning
<p>Some models of associative learning attempt to explain effects such as blocking and unblocking as reflecting a prediction error (PE): Associative strength, and thereby learning, are said to be greater when the unconditioned stimulus (US) received following a cue deviates from one’s expectations. …
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Downregulation of miR-10a-5p as a Potential Therapeutic Target to Improve the Detrimental Effects of Post-stroke Social Isolation
… treated with a miR-10a-5p antagomiR had improved behavioral outcomes compared to SI negative control treated animals while no significant behavioral effect was seen in females. In open field testing, SI males treated with antagomiR were more active then negative control treated animals. There were …
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Hypothalamic Circuits Mediating Consumption and Anxiety
<p>From 1960-2016, U.S. obesity prevalence increased 13-40% and diabetes increased from 3-15%. There is an epidemic of <em>metabesity</em>, the aggregate metabolic disorders produced by chronic overeating. Drugs for metabesity were developed in the 1930s with limited effectiveness; agents today …
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Neural Development to Neurodegeneration Through the Mind of a Worm
<p>Defects in the nervous system can impact the normal function of an organism. By examining mutations during neuronal development, we can better understand the significance of specific pathways. The EphR/ephrin pathway is crucial for axonal guidance during development. The simple organism, <em>C. …
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Biological motion processing in typical development and in the autism spectrum
… disorder (cASD) demonstrated both typical BM behavioral ability as well as typical BM-related electrophysiological activity as manifest in the interactions between group and the three BM stimulus-responses (UM, IM, SM). Notably, all three stimulus-responses individually generated similarly …
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Optogenetic Interrogation of Primary Visual Cortex and Its Impact On Neural Coding and Behavior
… has been implicated as a major source of behavioral choice related activity in the cortex, and theorized to be a major factor limiting information in cortical populations. However, until now, there has not been a way to manipulate correlations without altering firing rates or other task …
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Non-Photic Mechanisms of Entrainment In Bmal1 Deficient Conditions
<p>Maintaining our internal circadian (i.e. 24 -hour) clock is imperative to our daily biological and mental well-being. Large epidemiological studies have shown that disruptions of our circadian rhythms can lead to poor mental health, metabolic diseases, and various types of cancer. Various …
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Mtorc1 Signaling In Memory Formation and Dysfunction
<p>The mechanistic Target of Rapamycin Complex 1 (mTORC1) pathway integrates cellular availability of growth factors, energy and amino acids to regulate protein synthesis and autophagy. The mTORC1 pathway has also been shown to be required for memory consolidation, and its dysregulation is …
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Evaluation of Seizure Threshold as an Early Behavioral Marker of Disease Progression in the Mouse Model of Mucopolysaccharidosis IIIA
… the Barnes maze and novel object recognition behavioral assays did not show a neurological defect earlier than 20 weeks. These results suggest an intact cognitive capacity for the diseased animals. To test whether seizure threshold is altered in diseased animals, mice were administered with …
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