Global ETD Search
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Showing 1 to 8 of 8 for “"Behçet’s disease"”.
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Expression and function of the NLRP3 inflammasome in Behçet’s disease
연구배경: 베체트병운 점막 및피부, 눈, 혈관, 신경 및 기타 여러 장기를 침범할 수 있는 임상적 특징을 가지는 만성, 재발성의 전신질환이다. 현재까지 베체트병에서 보이는 지속적인 염증 반응의 정확한 원인 기전은 밝혀져 있지 않으나 베체트병이 감염에 의해 촉발되는 자가면역 질환과 자가염증 질환의 경계선상에 있을 것이라는 주장이 제기되고 있다. 최근 그람 음성균 감염 후 발생한 구내염 환자에서 NLRP3 inflammasome를 매개로 한 전신 염증의 가능성이 보고 되고 있으나 아직까지 베체트병에서 NLRP3 …
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The role of T cell Immunoglobulin Mucin domain in Herpes Simplex Virus-induced Behçet’s Disease mouse model
… markers for asthma, allergies and autoimmune diseases, as well as potential cell surface markers for T helper type (Th)1 and Th2 T cells. TIM-1 plays an important role in the regulation of immune responses and the development of autoimmune diseases. TIM-4 is a natural ligand of TIM-1, and …
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Identification of macrophage phenotypes and evaluation of their role in the immunopathogenesis in animal model of Behçet’s disease
… abnormalities have been demonstrated in Behçet’s disease (BD), the exact mechanism of the inflammatory changes occurring during the development of this disease remains unclear. Macrophage phenotypes are markedly heterogeneous and include classically activated (M1) and alternatively …
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Differential Expression of T Cell Immunoglobulin- and Mucin-Domain-Containing Molecule-3 (TIM-3) According to Activity of Behçet's Disease
… a chronic inflammatory multisystemic disorder, Behçet’s disease (BD). However, TIM-3 expression and function in BD has not been investigated. PURPOSE: In this study, its was examined that the surface expression of TIM-3, the expression of TIM-3 protein and the TIM-3 mRNA in peripheral blood …
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Differential gene expression in Behcet's disease and differential anti-tumor effects of Tim3 pathway blocking molecules
… genes according to colchicine responsiveness in Behçet’s disease Behçet disease (BD) is a chronic relapsing, systemic inflammatory disorder which is treated with colchicine. However, some patients are not responsive to it. In this study, I wanted to explore the biomarkers to distinguish …
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The role of immunosenescence in autoimmune/autoinflammatory pathogenesis of Behçet's disease
Background and objectives: Behçet’s disease (BD) is a chronic inflammatory disease characterized by recurrent mucocutaneous ulceration and complications such as blindness and large vessel inflammation. Immunosenescence, aging of immune system, is related to increased susceptibility to infectious …
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MicroRNA as Regulator of the Th17 Inflammation in Behcet's disease
… of miRNAs in chronic inflammatory and autoimmune diseases. To date, microRNA-155 (miR-155) is one of the most highly implicated miRNAs in autoimmunity. Behcet’s disease (BD) is a chronic inflammatory disease with autoimmune nature, characterized by oral and genital ulcers and ocular inflammation. …
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Expression of Th17 and related cytokines according to clinical activity of Behcet's disease
Background: Behçet’s disease (BD) is a multisystem inflammatory disorder characterized by recurrent oro-genital ulcers, and cutaneous, ocular, arthritics, gastrointestinal, vascular, and neurovascular involvement. The etiology and pathogenesis of BD have remained unclear, however it has been …