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Showing 1 to 6 of 6 for “"Bco1"”.
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Dietary tomato carotenoids and β-carotene-15,15'- dioxygenase (Bco1) genotype alter androgen metabolism, lipid metabolism, and prostate cancer progression in mice
β-carotene-15,15'-dioxygenase (BCO1) cleaves dietary carotenoids at the central 15,15' double bond, most notably acting on β-carotene to yield retinal. Much work has gone into the description of enzymatic carotenoid cleavage activities of the enzyme, but although pleiotropic effects of Bco1 loss on …
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Lycopene metabolism in transgenic mice
… shows that two enzymes, ß-carotene oxygenase 1 (BCO1) and ß-carotene oxygenase 2 (BCO2), cleave carotenoids in vivo. Several animal trials show that lycopene can be cleaved by BCO2, but metabolites have been detected in mice lacking BCO2. Additionally, in vitro studies in E. Coli have …
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Defining risk for metabolic syndrome in young Mexican adults: the relationship between β,β-carotene-15,15'- oxygenase 1, nutrition and the lipid profile
… activity of β, β-carotene-15,15-oxyegenase 1 (BCO1). However, studies show that humans exhibit both low and high conversion rates of provitamin A carotenoids to functional retinoids. This may be due to single nucleotide polymorphism (SNPs) within and upstream of the BCO1 locus impart changes in …
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Early life nutrition and genetic contributors to carotenoid status in children
… who carried at least one T, C and A alleles on BCO1-rs7501331 (P = 0.045) , CD36-rs3173798 (P < 0.01), and CD36-rs1527483 (P = 0.04), respectively. Only CD36-rs3173798 (P < 0.01) remained a significant predictor for MPOD after accounting for dietary lutein and zeaxanthin intake. Conclusions. The …
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Lutein and α-tocopherol biodistribution in animal models
… (CD36, SCARB1, SCARB2, LDLR, STARD3, GSTP1, BCO1, BCO2, or RPE65). Dietary regimen did not impact the expression of carotenoid-related genes except for SCARB2. However, carotenoid-related genes were differentially expressed across brain and retina regions. Breastfed infants had higher serum …
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Using pro-vitamin A carotenoids as a therapeutic strategy to reduce the burden of obesity and atherosclerosis
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01