Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Bcl6"”.
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Elucidating the role of BCL6 in helper T cell activation, proliferation, and differentiation
The transcriptional repressor BCL6 has been shown to be essential for the differentiation of germinal center (GC) B cells and follicular T helper (TFH) cells. The interaction of TFH and GC B cells is necessary for the development of high affinity antibodies specific for an invading pathogen. …
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
… warranted. The transcriptional repressor Bcl6 is a critical arbiter of helper T cell fate, promoting the follicular helper (Tfh) lineage while repressing Th1, Th2 and Th17 differentiation. Bcl6-deficient mice develop a spontaneous and severe Th2-type inflammatory disease including …
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Harnessing synergy between BCL6 and PI3Kδ to generate a new mouse model for lymphoma
… mouse model of DLBCL was generated by knocking a BCL6 transgene into the Igμ locus (μHABCL-6Tg). Our lab has generated a mouse model of APDS in which a hyperactivated PI3Kδ (p110δE1020K) was knocked in constitutively or selectively in B cells or T cells. We crossed p110δE1020K knockin-mice with …
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The novel roles of BCL6 and BATF3 in regulating human CD8⁺ T cell dysfunction
… landscapes. Our analyses revealed that BCL6 and BATF3 are robustly upregulated in dysfunctional CD8⁺ T cells, with ATAC-seq demonstrating enhanced chromatin accessibility at their gene loci. Transcription factor footprinting shows increased BATF3 motif occupancy in chronically stimulated …
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Synthesis of cis- and trans-3-fluoroacrylate, and inhibition of BCL6 targeting a non-reactive cysteine
… inhibitor that targets the BTB-domain of BCL6 was made in a multi-step route. The compound builds on preliminary data that shows a “switchable electrophile” strategy can be used to selectively and irreversibly modify a cysteine within the corepressor peptide binding site in the BTB-domain …
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Molecular characterisation of Diffuse large B-cell lymphomas (DLBCL) diagnosed at Groote Schuur Hospital (GSH)
… alterations in oncogenes such as MYC, BCL2 and BCL6 as well as viral oncogenes, contribute to its development and progression. In the World Health Organisation (WHO) classification of haematolymphoid tumours, the classification of DLBCL requires testing for MYC, BCL2 and BCL6 genetic alterations …
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Follicular Regulatory T cell migration and differentiation
… and CXCR5 as key regulators of Tfr cell biology. Bcl6 drives Tfr cell differentiation, but how this transcriptional repressor facilitates commitment to the Tfr cell subset is unknown. I hypothesised that Bcl6 drives Tfr cell differentiation by repressing Tbx21, the transcriptional regulator …
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REGULATION OF ADAPTIVE IMMUNE RESPONSES TO PLASMODIUM CHABAUDI MALARIA INFECTION
… clearance. Whereas the transcription factors Bcl6, Blimp-1, and STAT3 regulate the development of Tfh cells, T-bet and STAT4 direct the commitment of Th1 cells. Since our understanding of the regulation of adaptive protective responses against malaria is poor, the present dissertation aimed to …
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Regulation of the germinal center reaction by T helper cells and T regulatory cells
… this process by transcription factors STAT3 and Bcl6. STAT3 is important for both TFH cell differentiation and IL-4 production by Th2 cells. IL-4 is a major functional cytokine produced by TFH cells. To dissect the role of STAT3 in IL-4 production by TFH cells, we generated T cell-specific …
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Oncogene-Induced Signaling Heterogeneity in Lung Cancer
… target Smad2/3 downregulated cells, I identify Bcl6, a downstream target of Smad2/3, and I show that Bcl6 is a novel targetable vulnerability in transformed HBECs. I observe that C-Myc and Bcl6 gene expressions are strongly correlated in cell populations as well as in single-cell level. I …
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Molecular Insights of Primary Thyroid B-cell Lymphomas by Somatic Genetic and Immunogenetic Profiling
… in situ hybridisation analysis for *BCL2* and *BCL6* translocation. The final diagnosis included 40 cases of EMZL (9 *BCL6* translocation positive), 22 cases of FL (5 *BCL2* translocation positive, 11 *BCL6* translocation positive, 1 both *BCL2/BCL6* translocation positive) and 36 cases of DLBCL …
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PI3Kδ in B cell Homeostasis and Transformation
… of hyperactive PI3Kδ with B Cell Lymphoma 6 (BCL6), a master regulator of the Germinal Center reaction. High dimensional phenotyping allowed for the identification of a pre-malignant pre-Plasmablast subset characterised by high expression of CD73. Adoptive cell transfer of CD73hi B cells into …
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Twist1 and Etv5 are part of a transcription factor network defining T helper cell identity
… cytokine production in Th9 and Th17 cells, and Bcl6 expression in Tfh cells. Thus, the transcription factors Twist1 and Etv5 provide unique regulation of T helper cell identity, ultimately impacting the development of cell-mediated and humoral immunity.
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IDENTIFYING EARLY STEPS IN THE DEVELOPMENT OF HBV ASSOCIATED HCC
… have arisen. Connecting these processes are UBD, BCL6, METTL24, CHRNA4, and NFKBIZ which putatively serve as crucial early drivers in the progression from HBV infection to the development of HCC and affect the serum level of downstream targets which could serve as biomarkers for earlier disease …
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Translational regulation in aggressive B-cell lymphomas
… that overexpression of two B-cell oncogenes, BCL6 or MYC, is followed by preferential translational of selected transcripts. Next, I show that loss-of-function mutations in RNA-helicase (DDX3X) promote early development of MYC-driven lymphoma by buffering the effects of MYC on translation of …
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Signaling pathways and novel therapeutic strategies for the treatment of murine chronic graft versus host disease
… that targeting the germinal center directly via BCL6 inhibition reduces cGVHD in GC-mediated murine models. Finally, we demonstrate the importance of Th17-prone cell subsets in human and murine cGVHD. Take together; these results identify pathways required for development of cGVHD as well as …
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Insights Into the Regulatory Requirements for T Follicular Helper Cell Development
… to the upregulation of the TFH associated genes Bcl6, Il21, and Icos, correlating with increased B cell helper activity. Conversely, exposure of these TFH-like cells to IL-7 results in the STAT5-dependent repression of Bcl-6 and subsequent inhibition of the TFH phenotype. Finally, we describe a …
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The role of Fyn and B-cell expressed ADAM10 in early B cell development, germinal center formation and terminal B cell differentiation
… and function and increased expression of Bcl6, an inhibitor of PC differentiation. Fyn kinase is a member of the Src protein tyrosine kinase. Fyn is widely expressed in many cell types, including lymphocytes. Fyn has been shown to interact with both the B cell and T cell receptor (BCR and …
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Molecular, functional and developmental analysis of B cells at discrete stages of development
… of BCL2 and PRDM1 and downregulation of BCL6. Surface Ig expression revealed that CD10+CD27+ B cells are a subset memory B cells that have undergone Ig class switching. Thus we conclude that CD10+CD27+ B cells represent a subset of IgM- memory B cells.
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Maintenance and function of antigen-specific CD4 T cells within the lung during tuberculosis
… expression of ICOS, the transcription factor Bcl6, and the chemokine receptor CXCR5. Furthermore we find that a majority of KLRG1+ IFN-γ producing CD4 T cells are located in the lung-associated vasculature and not in the lung parenchyma as previously thought. However, the PD-1+ population that …
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