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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 6 of 6 for “"Bcl-3"”.

  1. An investigation into the role of Bcl-3 in toll-like receptor signalling

    Collins, Patricia E.University College Cork2014

    … In this thesis the role of the IκB protein Bcl (B-cell lymphoma)-3 in the regulation of TLR signalling is investigated. Bcl3-/- mice and cells are hyper responsive to TLR stimulation and are defective in LPS tolerance. Bcl-3 interacts with and blocks the ubiquitination of homodimers of the …

    cork Repository record

  2. The NF-kappaB transcription factor: structure, function and interaction with the oncoprotein Bcl-3.

    Bours, VincentULiège - Université de Liège1994

    liege Repository record

  3. The role of the deubiquitinating enzyme CYLD and its substrate BCL-3 in solid tumors

    Ahlqvist, KristoferMolecular tumor Pathology2012

    The tumor suppressor CYLD and the proto-oncogene BCL-3 are known to be deregulated in various cancer types. The molecular background of how these genes participate in carcinogenesis is not fully understood. CYLD is a deubiquitinating enzyme known to specifically target lysine 63 linked ubiquitin …

    lund Repository record

  4. Investigation of toll-like receptor tolerance in the regulation of inflammation

    O'Carroll, Christine ElizabethUniversity College Cork2013

    … negative regulator of TLR gene transcription, Bcl-3 (Bcl-3-/-) in a model of intestinal inflammation, we investigated the role of Bcl-3 in the regulation of intestinal inflammatory responses. Our data revealed a novel role for Bcl-3 in the regulation of epithelial cell proliferation and …

    cork Repository record

  5. IL-1 activation of NF-kB contributes to perinatal hypoxia/ischemia induced cell death

    Xiaoming HuThe University of Texas Medical Branch2005

    … phosphorylated IkBa and nuclear translocation of Bcl-3, was also attenuated by IL-1Ra blockade, suggesting that HI-induced IL-1 activation of NF-kB is via both degradation of IkBalpha and nuclear translocation of Bcl-3. \r\nInhibition of NF-kB via decoys containing NF-kB binding consensus …

    utmb Repository record

  6. Roles of NF-kB in spinal cord injury pathophysiology

    Danny Salah RafatiThe University of Texas Medical Branch2005

    … level decreases in IkB family members, IkB-a and Bcl-3, suggesting early and prolonged activation of NF-kB up to 28 days after SCI. Validation of NF-kB activation was performed by immunohistochemical analyses of spinal cord cross sections and Western blot assay analyses. Immunohistochemical …

    utmb Repository record