Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Bcl-2 Proteins"”.
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Role of Bcl-2 proteins in neutrophil activation and delayed apoptosis in crystal-induced arthritis
… of activation and delay of apoptosis, however, bcl-2 family proteins have been implicated in the control of neutrophil apoptosis. This study helps to define the role of several bcl-2 family proteins (both pro- and anti-apoptotic) by examining the differential expression of these proteins upon …
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Vesicular stomatitis virus induced apoptosis occurs by a mechanism involving the activation of pro-apoptotic Bcl-2 proteins Bak and Bid and the inactivation of anti-apoptotic Bcl-2 proteins Bcl-XL and Mcl-1
… of my thesis I address the question of what role Bcl-2 family proteins play in apoptosis induced by vesicular stomatitis virus (VSV) with wild-type (wt) M protein (rWT virus). My results demonstrate that of the two major proapoptotic multidomain proteins Bak and Bax, Bak is more important for the …
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THE EFFECTS OF ACIDOSIS ON SURVIVAL PATHWAYS IN LYMPHOID MALIGNANCIES
… of several apoptosis-governing members of the Bcl-2 family. More specifically, we find that acidosis signals the elevation of anti-apoptotic Bcl-2 and Bcl-xL, while also reducing levels of pro-apoptotic PUMA and Bim. Further mechanistic studies revealed that the induction of anti-apoptotic …
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Mechanisms of BAK Activation in the Initiation of Mitochondrial Apoptosis
… being regulated by B-Cell Lymphoma-2 (BCL-2) proteins. Deregulation of BCL-2 proteins form the basis for myriad of human pathologies including cancer and autoimmune diseases. Therefore, BCL-2 proteins are considered key therapeutic targets. BCL-2 homologous antagonist/killer (BAK) is an …
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Flexibility and specificity of the interaction of MCL-1 with BIM BH3
Interactions among proteins of the BCL-2 family regulate apoptosis - the process of programmed cell death. This thesis focuses on interactions between anti-apoptotic BCL-2 proteins and BH3 peptides derived from pro-apoptotic BCL-2 proteins, observed in earlier studies to occur with significant …
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Bim Mediates Imatinib-Induced Apoptosis of Gastrointestinal Stromal Tumors: Translational Implications
… of apoptosis), a pro-apoptotic member of the Bcl-2 family, effects apoptosis in oncogene-addicted malignancies treated with targeted therapies, and was recently shown to mediate imatinib-induced apoptosis in GIST. This dissertation examined the molecular mechanism of BIM upregulation and its …
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Approaches Towards the Inhibition of Anti-Apoptotic Proteins
Anti-apoptotic proteins play a fundamental role in cell survival. Under physiological conditions, such proteins trigger apoptosis in defective or damaged cells only; under pathological conditions, however, they can be dysregulated allowing the cells to survive despite being harmful. Considering the …
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Design of protein-protein interaction specificity using computational methods and experimental library screening
… and applied it to the design of anti-apoptotic Bcl-2 proteins with novel interaction specificity toward BH3 peptides. Finally I proposed how these two approaches can be combined together to further enhance our design capabilities.
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Studies on Fortilin-Prohibitin Interaction
… to other regulators of apoptosis, such as the Bcl-2 Proteins or the Inhibitors of Apoptosis proteins. In elucidating the mechanism of Fortilin-mediated cellular protection, fortilin protein interactions have been previously shown to modulate the cellular response to apoptotic stimuli. The goal …
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Design of selective peptide inhibitors of anti-apoptotic Bfl-1 using experimental screening, structure-based design, and data-driven modeling
… Designer reagents that selectively bind to proteins and inhibit their interactions can be used to probe protein interaction networks, discover druggable targets, and generate potential therapeutic leads. Current technology makes it possible to engineer proteins and peptides with desirable …
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The Modeling and Analysis of the Apoptotic BAD/tBID/BAK Pathway as a Chemical Reaction Network
… and dynamically well-behaved exchange of BAD for Bcl-2 proteins which guard against tBID activation. The second sub-network, tBID/BAK, is formulated as a complex-balanced network with a perturbation representing the reaction of tBID catalyzing the activation of BAK. Our theoretical results produce …
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Targeting Apoptotic Pathways to Overcome Drug Resistance In Acute Myeloid Leukemia
… integral to tumorigenesis and drug resistance. BCL-2 and p53 proteins represent two focal nodes in convergent apoptosis signaling. Upregulation of anti-apoptotic BCL-2 family members and inactivation of p53 functions are two canonical approaches exploited by cancer cells to escape apoptosis. In …
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Determinants of protein-peptide interaction specificity in the Bcl-2 and TRAF families
… domain families discussed in this work, Bcl-2 and TRAF proteins, have roles in cellular processes including apoptosis, inflammation, and immunity. Aberrant function of these proteins has been linked to a variety of diseases. There is great interest in understanding the mechanistic basis …
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Polymerizable Peptide Monomers for the Targeted and Intracellular Delivery of Cancer Therapeutics
… strategy is peptides derived from the third Bcl-2 homology domain (BH3), which antagonize pro-survival Bcl-2 proteins and induce apoptosis. Unfortunately, before the clinical potential of peptides can be realized, a number of drug delivery barriers must be overcome. Namely, peptides have …
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The interplay between pro-death and pro-survival signaling pathways converging at mitochondria in myocardial Ischemia/Reperfusion : Apoptosis meets Autophagy
… linked through the interaction of anti-apoptotic Bcl-2 proteins with the autophagy protein Beclin1. In this thesis a two-tiered relationship between autophagic activity and anti-apoptotic Bcl-2 was revealed: under normal conditions Bcl-2 is a necessary participant in autophagy via its interaction …
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Repurposing Alzheimer’s disease medications in a drug combination for the study of the crosstalk between cell apoptosis and autophagy in the modulation of cell death in chronic myeloid leukaemia
… Western blot analyses were carried out and the proteins of interest were quantified using Image Studio software on the Odyssey® Fc LI-COR Imaging System. The results demonstrated that the chemotherapy drug, Doxorubicin, caused death in both HEK293T and K-562 cells by modulating the apoptotic …
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pH-Triggered Membrane Insertion of Proteins
Several classes of membrane proteins refold from their original soluble conformations in response to acidification and insert into lipid bilayers. Despite the recent advances in unraveling the molecular mechanisms of pH-triggered insertion of membrane proteins, many aspects of this process remain …
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Mechanismen der Inhibierung von Wirtszellapoptose durch <i>Toxoplasma gondii</i>
… die in dieser Arbeit gezeigte Modulation der Bcl-2-Proteine eine wichtige Rolle spielen. Allerdings kann eine zusätzliche Inhibierung durch Verhinderung der Apoptosombildung nicht komplett ausgeschlossen werden.Wie T. gondii die Cytochrom c-Freisetzung aus den Mitochondrien des intrinsischen …