Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 266 for “"Bcl-2"”.
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Bcl-2 Function in Drosophila
Bcl-2 family members are pivotal regulators of programmed cell death (PCD). In mammals, pro-apoptotic Bcl-2 family members initiate early apoptotic signals by causing the release of cytochrome c from the mitochondria, a step necessary for the initiation of the caspase cascade. Worms and flies do …
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Die Rolle von Bcl-2 bei der UV- und TRAIL-induzierten Keratinozytenapoptose
… detektierbar. Die Überexpression des Proteins Bcl-2 verhindert den Verlust des mitochondrialen Transmembranpotentials und die Caspase-Aktivierung nach UVB, und vermittelt auch einen klonogen Schutz, unabhängig von der Bildung reaktiver Sauerstoffradikale. Im Gegensatz dazu verzögert es den …
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Characterization of a novel pro-apoptotic role for nuclear associated BCL-2
… In the case of stroke, an initial increase in Bcl-2 expression traditionally follows ischemia/re-perfusion. A major goal of stroke therapy is to rescue the peri-ischemic region of cells that have up-regulated Bcl-2 but have not yet committed to the execution phase of apoptosis. A strong …
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Determinants of protein-peptide interaction specificity in the Bcl-2 and TRAF families
… domain families discussed in this work, Bcl-2 and TRAF proteins, have roles in cellular processes including apoptosis, inflammation, and immunity. Aberrant function of these proteins has been linked to a variety of diseases. There is great interest in understanding the mechanistic basis …
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Die Bedeutung des Bcl-2 Familienmitgliedes Bim in der negativen Selektion von B-Zellen
In der vorliegenden Arbeit wurde die Rolle von Bim in der durch BCR-Stimulation vermittelten Apoptose und der negativen Selektion von B-Zellen untersucht. Dabei zeigte sich sowohl in vitro als auch in vivo, dass Bim essentiell für die BCR-vermittelte Apoptose ist.
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Implication of Bcl-2 family members in apoptosis signalling pathways triggered by growth factor deprivation
… shown to belong to the BH3-only members of the Bcl-2 family and promoted apoptosis by antagonizing the pro-survival function of Bcl-2 protein. Biochemical and confocal studies demonstrated that association of ITM2Bs to mitochondria correlated with loss of mitochondrial membrane potential, …
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Der C-Terminus des antiapoptotischen Bcl-2 Familienmitgliedes A1 reguliert Stabilität und Funktionalität des Proteins
… kann durch Überexpression des antiapoptotischen Bcl-2 Familienmitglieds A1 verhindert werden. Interessanterweise besitzt A1 im Gegensatz zu Fast allen anderen Bcl-2 Proteinen keinen C-terminalen Bereich, der das Protein in intrazelluläre Membranen wie Mitochondrien und Endoplasmatisches Retikulum …
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Role of Bcl-2 proteins in neutrophil activation and delayed apoptosis in crystal-induced arthritis
… of activation and delay of apoptosis, however, bcl-2 family proteins have been implicated in the control of neutrophil apoptosis. This study helps to define the role of several bcl-2 family proteins (both pro- and anti-apoptotic) by examining the differential expression of these proteins upon …
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Vesicular stomatitis virus induced apoptosis occurs by a mechanism involving the activation of pro-apoptotic Bcl-2 proteins Bak and Bid and the inactivation of anti-apoptotic Bcl-2 proteins Bcl-XL and Mcl-1
… of my thesis I address the question of what role Bcl-2 family proteins play in apoptosis induced by vesicular stomatitis virus (VSV) with wild-type (wt) M protein (rWT virus). My results demonstrate that of the two major proapoptotic multidomain proteins Bak and Bax, Bak is more important for the …
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Neuroprotective Effects of Anthocyanins on Neuronal Death Induced by Inhibition of Bcl-2 and Oxidative Stress
… intrinsic apoptosis were induced in CGNs by the Bcl-2 inhibitor, HA14-1. Callistephin and kuromanin each demonstrated significant neuroprotection from this MOS-induced death that was equal to that provided by the green tea polyphenol, epigallocatechin 3-gallate; however, neither anthocyanin was …
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Polarizable Simulations of the bcl-2 DNA G-Quadruplex and FMRP RNA G-Quadruplex:Duplex Junction Binding Protein
… to the stability of two GQs. One is the bcl-2 promoter region GQ, which is implicated in several types of cancer including B-cell lymphoma, and the second is the sc1 RNA GQ, which binds to the Fragile-X Mental Retardation Protein (FMRP) and is implicated in the development of Fragile X …
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Mechanisms of 17-beta-estradiol regulation of the proto-oncogene Bcl-2 in MCF-7 human breast cancer cells.
… the mechanisms of estrogen regulation of Bcl-2 were investigated by analyzing the expression of different Bcl-2 promoter-driven constructs stably transfected into MCF-7 cells. An approximately 1.7 kilobase (kb) sequence which directed estrogen-dependent regulation of Bcl-2 expression in …
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Basil cell carcinoma: an immunohistochemical assessment of P53, BCL-2 and CD138 in low and high-risk histological subtypes
… of tumoural p53 and decreased expression of BCL-2 and CD138 compared with low-risk patterns. In addition, peritumoural expression of CD138 has been noted to increase in the stroma of high-risk BCCs. These observations have largely been made by light microscopy rather than with digital …
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The role of the Bcl-2 family in proliferation and apoptosis and in mediating the development of lymphatic diseases
The development of the immune system is a highly dynamic process, characterized by quickly and frequently changing cell types and numbers. The orchestration of cell growth and proliferation and also of cell death is a necessarily complex process, taking cues from a wide variety of sources. The …
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