Global ETD Search
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Showing 1 to 10 of 10 for “"Bayesian adaptive design"”.
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The application of Bayesian adaptive design and Markov model in clinical trials
In this research, two new designs in clinical trials are proposed. The first problem is a new Bayesian adaptive dose-finding design and its application in an oncology clinical trial. This design is used for phase IB studies with the biomarker as the endpoint and with the fewer patients. The second …
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An Adaptive Bayesian Approach to Bernoulli-Response Clinical Trials
… outcome of Bernoulli-response clinical trials. A Bayesian adaptive design is used to fit the logistic equation to the dose-response curve of Phase II and Phase III clinical trials. Because of inherent restrictions in the logistic model, symmetric candidate densities cannot be used, thereby …
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Bayesian adaptive designs for non-inferiority and dose selection trials.
… a way that can be used as the trial progresses. Bayesian methods offer a highly flexible means of using such information yielding inferences and decisions that are consistent with the laws of probability and consequently admit ease of interpretation. Bayesian adaptive sampling methods offer the …
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Bayesian Adaptive Clinical Trial Design
… agents, making the conventional trial design paradigm inefficient and dysfunctional. Specifically, the focus of dose-finding trials has shifted from finding the maximum tolerated dose (MTD) to the optimal biological dose (OBD), defined as the dose that optimizes the risk–benefit …
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Topics in Bayesian adaptive clinical trial design using dynamic linear models and missing data imputation in logistic regression.
Conventional Phase II clinical trial designs usually employ a logistic regression model to analyze the efficacy of a new drug and, therefore, assumes monotone dose-response relationship. Also, the logistic regression model requires the response to be categorical and, thus, it is not applicable for …
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Novel combination strategies with Aurora Kinase Inhibitors: using pre-clinical data to guide clinical trial design
… (AKI) in pre-clinical models and then to design a clinical trial to assess these in patients with bladder cancer. Particular interest was stimulated by the correlation between over-expression of aurora kinases (AKs) with aggressive clinical behaviour in many cancers and the network of …
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Bayesian Adaptive Designs For Proof-of-Concept Trials and Platform Trials
… It’s crucial to develop novel phase II trial designs to accomplish different objectives for different types of trials. This research mainly focuses on Bayesian adaptive designs for phase II trials. Three types of trials are discussed in which traditional designs may encounter limitations, and …
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Bayesian Adaptive Designs and Versatile Software Platform For Early Phase Clinical Trials
… is dedicated to improve the efficiency of Bayesian adaptive designs for early phase clinical trials. Phase I clinical trials can be conducted using algorithm-based (also known as rule-based), model-based, or model-assisted designs. Numerous studies have shown that model-assisted designs …
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Bayesian Adaptive Designs For Early Phase Clinical Trials
<p>My dissertation focuses mainly on Bayesian adaptive designs for phase I and phase II clinical trials. It includes three specific topics: <strong>(1)</strong> proposing a novel two-dimensional dose-finding algorithm for biological agents, <strong>(2)</strong> developing Bayesian adaptive …
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Bayesian Designs For Early Phase Clinical Trials With Novel Target Agents
<p>My dissertation mainly focus on Bayesian designs for early phase clinical trials with novel target agents. It includes three specific topics: (1) reviewing novel phase I clinical trial designs and comparing their operating characteristics; (2) Proposing a Bayesian optimal phase II clinical trial …