Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 161 for “"Bax"”.
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Bax-Inhibitor-1-vermittelte Neuroprotektion
BI-1 (Bax-Inhibitor-1) konnte in Hefen, Pflanzen und verschiedenen Säugetierzellen vorwiegend als anti-apoptotisches Protein charakterisiert werden.Um die Funktion von BI-1 in Neuronen zu untersuchen, wurde sowohl HA- als auch GFP-getaggtes BI-1 transient und stabil in CSM14.1- (nigro-striatale …
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Delineating the Steps of BAX Pore Activation
… proteolytic demolition of cells. Proapoptotic BAX & BAK effect the release of cytochrome c while their antiapoptotic counterparts like BCL-2, BCL-X<sub>L</sub>, & MCL-1 oppose this permeabilization. A third class of the BCL2 family, the prodeath BH3-only proteins, act as sentinels of cell …
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Regulation of BAX/BAK-Dependent Cell Death Program
… apoptosis. Multidomain proapoptotic BAX/BAK promotes mitochondrial outer membrane permeabilization, whereas anti-apoptotic BCL-2/BCL-X<sub>L</sub>/MCL-1 protects mitochondrial integrity and prevents cytochrome c release. The proapoptotic activity of BAX/BAK is triggered by BH3-only …
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Hedging Canadian short-term interest rates : the BAX market
… Bankers' Acceptance Futures contract, the BAX, which was introduced on the Montreal Exchange in the early eighties as an instrument to manage interest-rate risk. Institutional features of the BAX market and the growth of this market, particularly in the second part of the 1990s, are …
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The Role of Bax and Bak in Necrotic Cell Death
… (ROS) stimulation. Here we determined that Bax and Bak, Bcl-2 family members that are master regulators of apoptosis, are also required for programmed necrosis induced by Calcium, ROS, and DNA alkylation. These results led us to hypothesize that Bax and Bak are required for MPTP opening. …
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Structural and Spatiotemporal Organisation of Bax and Apaf1 during Apoptosis
… of two essential steps of apoptosis, Bax cluster formation and Apaf1 activation, using a combination of biochemical and microscopy approaches. I sought to better understand the contribution of spatial and structural protein organisation within cells towards the efficient promotion of …
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Molecular function and regulation of the Bax-associating protein MOAP-1
Bax is a central regulator for controlling the release of apoptogenic factors from mitochondria. MOAP-1 has previously been identified as a Bax-associating protein, but its regulation and functional relationship with Bax in apoptosis signalling remains unclear. In this thesis, MOAP-1 is found to be …
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In vivo- und in vitro-Funktionsanalysen von Bax Inhibitor-1 bei humanen Karzinomzellen
… mutiert oder fehlerhaft reguliert. Das Bax Inhibitor-1 (BI-1)-Gen kodiert für ein antiapoptotisches Protein, welches die Wirkung von Bax aufheben kann. Für das BI-1-Gen konnte eine erhöhte Expression bei der Progression von Tumoren nachgewiesen werden. In der vorliegenden Arbeit wurde …
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Revelation of new properties of pro-apoptotic human proteins, Bax and α-synuclein, using baker's yeast
… for post-mitotic cells such as neurons. Bax and α-synuclein are two human proteins which play a role in the induction of neuronal apoptosis in neurodegenerative diseases like Alzheimer’s and Parkinson’s. Human Bax and α-synuclein also induce cell death when expressed in baker’s yeast, …
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Expression of Bax Predicts Outcome in Advanced Gastric Cancer Patients Treated With 5-fluorouracil and Platinum Palliative Chemotherapy
… present study evaluated the predictive role of Bax, excision repair cross-complementation group 1 (ERCC1), and thymidylate synthase (TS) on clinical outcomes in patients with advanced gastric cancer treated with 5-fluorouracil (5-FU) and platinum palliative chemotherapy. Materials and Methods: …
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A song of war and victory : an edition, commentary, and analysis of the 1905 tone poem by Sir Arnold Bax
Many of the musical works composed by Sir Arnold Bax have been studied, edited, and performed in the fifty or so years since his death in 1953. Until recently, several of the earliest symphonic works have remained as original unedited manuscripts tucked away in private collections. This …
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Bax-mediated coordination of cognate organelle cell death signaling cascades determines cell death phenotype after trauma in the neonatal rat cortex
Bax translocation to the mitochondria has been well-characterized to induce apoptotic cell death in multiple injury paradigms. However, pro-cell death actions for Bax outside of the mitochondria remain understudied. Bax’s pro-cell death role at other non-mitochondrial locales in response to …
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Role of Macrophage Apoptosis in Atherosclerosis.
… remains to be elucidated. Elevated expression of Bax, one of the pivotal pro-apoptotic proteins of the Bcl-2 family, has been found in human atherosclerotic plaques. Activation of Bax also occurs in free cholesterol-loaded and oxysterol treated mouse macrophages. In this study, we evaluated the …
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The Early Events and Long-Term Effects of Perinatal Cerebral
… that is transferred to the next generation. Bax, a cell death signaling protein, is activated after HI, and translocates to the nucleus, ER, and mitochondria. Translocation patterns of Bax affect the cell death phenotype (necrotic or apoptotic) observed. Once activated, Bax is known to …
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Identification of Apoptotic Regulators in the Cervix of Pregnant Mice in Association with Cervical Softening
… ,TUNEL. And then the expressions of the Bcl-2, Bax, Caspase-3, Caspase-6 were analyzed. Stromal arrangements associated with apoptosis were assessed. Apoptosis is detected significantly during late pregnancy by TUNEL. On Western blotting; Expression of Bcl-2 was decreased progressively during …
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Studie van het celdoodproces in candida albicans
… S. cerevisiae differs from that in C. albicans. Bax is a pro-apoptotic protein involved in the regulation of genetically programmed cell death in mammalian cells. It has been shown that heterologous expression of Bax in several yeast species also induces cell death. We investigated the effects of …
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REGULATORY MECHANISM OF DUSP16 IN CANCER RESISTANCE TO PLATINUM-BASED THERAPIES
… p38 leading to phosphorylation and activation of Bax, a pro-apoptotic member of the Bcl-2 protein family. Activated Bax translocate to mitochondria to trigger caspase 9/3 apoptosis. We showed that inhibition or knocking out of Bax in DUSP16-overexpression cells abrogated DUSP16-mediated …
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A Study to Investigate Factors Involved in the Development of Oesophageal Carcinoma
… of apoptosis or programmed cell death and bax is a promoter. p53 is a protein regulating these. Studies have shown a bcl-2/bax ratio favouring bax expression to be predictive of a good response to neoadjuvant chemoradiotherapy; that expression of mutated p53 is predictive of a poor …
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