Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Batch-to-batch variation"”.
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Investigation of the factors contributing to the physical stability of biological therapeutics
… are becoming increasingly commonly used due to their specificity and efficacy. Unfortunately, they can suffer from aggregation, resulting in immunogenicity and poor bioavailability. The mechanisms behind such losses in physical stability, which is itself sensitive to a wide range of factors, …
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Chemical characterisation of the volatile constituents of essential oil from Commiphora Wildii (Omumbiri) resin
… Omumbiri essential oil which they supply to companies in Namibia, South Africa, Germany and France. However, most of their products are sold in Southern Africa, and supply outweighs the demand. OPF is currently working on improving the reproducibility of production of the oil to make it …
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Investigating the Structure and Physical Stability of Glp1-Like Peptides Using Mass Spectrometry
… fibrillation prone peptides is an adventure, to say the least, but harnessing their therapeutic potential is a challenge worth facing. On comparison to small molecules, peptides provide improved efficacy coupled with reduced toxicity; the difficulty lies in their pharmaceutical developability, …
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Small molecules based on novel electron-deficient acceptor units for organic electronic applications
Demand for photovoltaic cells is ever-increasing due to the diminishing supply of oil-based fuels and the associated harmful environmental effects. Organic photovoltaic devices offer a light and flexible alternative to Si-based PVs. In addition to this, they can be processed using fabrication …
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Rheological characterisation of solder pastes and isotropic conductive adhesives (ICAs) for microsystems assembly technology
… required for flip-chip pitch sizes, is expected to result in increased stencil clogging and incomplete transfer of paste to the printed circuit board pads. The paste printing process depends on conditions such as good paste roll, complete aperture filling and paste withdrawal. The paste rheology …
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Improving the Stability of Organic Field-Effect Transistors
… solution-processing, organic field-effect transistors (OFETs) have evolved from a convenient tool for semiconductor parameter analysis to a technology slowly entering the market as circuit components in flexible electronics. Since the first devices in the 1980s, OFET mobilities have increased by …
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A drug-free theranostic approach for localized and systemic diseases via nanoparticles
… addressing the biomedical challenges created a toolkit which has been evolving dynamically with the advances in the medicine itself. At the heart of nanomedicine, nanoparticles exist which are envisioned to shift the paradigm of conventional therapy by furnishing the field with their …
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Optimization and characterisation of plant produced Human Papillomavirus pseudovirions in Nicotiana benthamiana
Human papillomavirus (HPV) is known to be the cause of anogenital and oropharyngeal cancers as well as genital and common warts. There are currently three prophylactic virus-like particle (VLP) based vaccines. These vaccines, however, do not offer protection against all HPV strains and cannot act …
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Characterisation of lead-free solder pastes and their correlation with the stencil printing process performance
… whose properties are governed by many factors. Variations exhibited in solder paste characteristics make it increasingly difficult to understand the correlations between solder paste properties and their printing process performance. The recent EU directives on RoHS (Restriction of …
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3D Cell Culture in Microgels: A Novel Screening Platform for Disease Modelling and Drug Testing
… make it through clinical trials and are brought to the market. This low success rate has been attributed to a lack of relevant cancer models. New drug candidates are usually tested on 2D cancer cell lines adhered to a plastic surface, which neglect many aspects of a tumour in vivo, such as …