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Showing 1 to 7 of 7 for “"Batch crystallization"”.
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Simulation and Optimization of Batch Crystallization Processes
Crystallization from solution has been widely used in the industry because of its ability to provide high purity separation. The increased competition has motivated great interest toward quickly modeling and simulating the crystallization processes, as well as the development of optimal control …
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Robust Nonlinear Control Using Bilinear Matrix Inequalities With Application to a Batch Crystallization Process
The controller design problem necessitates the solution of an optimization problem under bilinear matrix inequality constraints, which is a nonconvex optimization problem, has been shown to be NP-hard, and its efficient solution is also an open research problem. Various solution strategies have …
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Robust optimization techniques and design of Li-ion batteries
… in the design of the Li-ion battery and a batch crystallization process. The proposed approach yields an analytic expression for the computation of the variance in the optimization objective that is cheap to evaluate computationally. The estimates of the variance incorporated into the …
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Novel continuous crystallization configurations for improved yield, purity and controlled crystal size distribution
Continuous crystallization process has potential advantages such as lower cost and improved flexibility in pharmaceutical production when compared to batch crystallization. A good continuous crystallization process should achieve a high product yield and purity comparable to current batch …
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DEVELOPMENT OF NOVEL DESIGN AND CONTROL APPROACHES FOR INTEGRATED CRYSTALLIZATION OPERATION AND SYSTEMS
Crystallization is an important separation and purification technique for a wide variety of solid products in pharmaceutical, food and fine chemical industries. The production of more than 90% of the active pharmaceutical ingredients (APIs) involves crystallization. Therefore, it is crucial to …
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A process for separation by semi-continuous counter-current crystallization
A process is proposed to perform separations via crystallization by using multiple tanks and constraining crystal growth to solid surfaces. Multiple tanks allow multiple recrystallizations to improve product purity and to ensure high recovery of the component of interest. Crystal growth on solid …
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Direct Precipitation of Micron-Size Salbutamol Sulphate by Antisolvent Crystallization
… size (between 1 and 5 ?m) through antisolvent crystallization in the presence of surfactants and polymeric additives. Salbutamol sulphate (SS) was used as the model drug compound. Several candidate antisolvents were screened via studying particle morphology, particle size and agglomeration of …