Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Basolateral Amygdala"”.
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Dopaminergic modulation of basolateral amygdala for fear extinction
… extinction learning, a new memory is formed in basolateral amygdala (BLA) reward neurons, which inhibits the BLA fear memory. However, the neurological nature of the teaching signal that instructs the formation of fear extinction memory in BLA reward neurons is unknown. Recently work has …
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Influence of Sex, Adolescence, and Aging on the Rat Basolateral Amygdala
… of sex, adolescence, and aging on the rat basolateral amygdala. Study one was a neuroanatomical Golgi study that examined dendritic material in adult and aged male and female basolateral nucleus, and found significant age-related increases in dendritic material in both sexes, along with a …
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The molecular substrates of second-order conditioned fear in the basolateral amygdala
… of fear. Both require neuronal activity in the basolateral amygdala complex (BLA), including activation of NMDA receptors, for their encoding, and both require CaMK signalling, gene expression and DNA methylation for their consolidation. However, de novo protein synthesis is required for …
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NMDAR-PSD95-nNOS Axis-Mediated Molecular Mechanisms in the Basolateral Amygdala Underlying Fear Consolidation
… and impairs long-term potentiation of basolateral amygdala (BLA) neurons in a rodent model of auditory fear conditioning. However, the molecular mechanisms by which disrupting the PSD95-nNOS interaction attenuates fear consolidation are not well understood. Here, we used pharmacological …
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Spatial, temporal, and circuit-specific activation patterns of basolateral amygdala projection neurons during stress
In humans and rodents, the amygdala is rapidly activated by stress and hyperactivated in conditions of pathological stress or trauma. However, there is a striking lack of information of the anatomical specificity of amygdala subregions and circuits explicitly activated by stress, and of its role in …
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Examining the Roles of GABAA Receptor Subtypes in Anxiety and Anxiolysis: Focusing on the Basolateral Amygdala
… anxiolysis both systemically and within the basolateral amygdala (BLA), a brain region crucial for anxiety-like behaviors, we examined the anxiolytic-like effects, as measured by elevated-plus maze test (EPM), of several subtype selective and non-selective GABA<sub>A</sub>R positive …
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Ethanol Enhancement of Two Distinct Inhibitory Pathways in the Rat Basolateral Amygdala: Implications for Anxiety and Alcoholism
The basolateral amygdala (BLA) acts as a key interface between the interpretation of external stimuli and the production of emotional responses, such as fear and anxiety. As such, the BLA is activated in response to stressful stimuli, then integrates and projects this information to target brain …
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Development of the adolescent prefrontal cortex and basolateral amygdala and the effects of puberty and alcohol exposure
… such as the prefrontal cortex (PFC) and the amygdala continue to develop throughout adolescence into early adulthood. These studies have specifically shown that the volume of the PFC increases until puberty and then decreases until early adulthood. By contrast, the amygdala has been shown to …
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ADENOSINE SYSTEM DYNAMICS AND SK CHANNELS MODULATE BASOLATERAL AMYGDALA PYRAMIDAL CELL EXCITABILITY: IMPLICATIONS FOR ANXIETY DISORDERS AND COMORBID ETHANOL ABUSE
Alcohol use disorders (AUDs) impart serious social and economic costs on society. For example, nearly 1 in 18 Americans abuses or is addicted to alcohol, contributing nearly $234 billion per year in socioeconomic costs. Despite this, effective pharmacological treatments remain elusive. To aid in …
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Infusion of oxytocin into the basolateral amygdala facilitates, whereas infusion into the central nucleus impairs extinction of context conditioned fear responses in rats
Increasing oxytocin (OT) in the central amygdala (CeA) via infusion of a selective OT agonist (Viviani et al., 2011) or optogenetic stimulation of hypothalamic neurons (Knobloch et al., 2012) reduced conditioned freezing responses. In contrast, intracerebroventricular (i.c.v.) administration of OT …
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A STUDY ON THE EFFECTS OF CHRONIC ALCOHOL AND WITHDRAWAL IN THE BASOLATERAL AMYGDALA OF SPRAGUE DAWLEY RATS: AFFERENT SPECIFIC MODIFICATION OF GLUTAMATERGIC NEUROTRANSMISSION
The lateral and basolateral amygdala (BLA) are major amygdala subdivisions that process environmental stimuli in an associative process that ultimately results in anxiety-like or fearful behavioral responses. These nuclei receive glutamatergic input via two major pathways differentiated by their …
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Social and economic decision-making in Urbach-Wiethe Disease
… Rodent and primate research have identified the basolateral amygdala as indispensable for social decision-making. This finding has not yet been translated to humans, and has even been partially contradicted by previous findings in patients with amygdala lesions that show generous economic …
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A Study on the Effects of Chronic Alcohol and Withdrawal on the Glutamate, GABA, and Dopamine Systems in the Basolateral Amygdala of Sprague Dawley Rats
… to treat alcohol withdrawal-induced anxiety. The amygdala, in particular the basolateral amygdala (BLA), has been shown to be an important brain region in initiating and processing sensory information pertaining to anxiety-related stimuli in humans and rodents. The BLA also plays a major role in …
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MUNC13 PROTEINS REGULATE STRAIN-DEPENDENT EFFECTS OF ETHANOL-MEDIATED INHIBITION OF SYNAPTIC VESICLE RECYCLING
… in glutamatergic transmission within the basolateral amygdala (BLA). We have also demonstrated that this hyperexcitable state contributes to the expression of withdrawal related anxiogenesis and can be ameliorated by glutamatergic antagonists. However, it remains unclear how acute exposure …
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Effects of developmental PCB exposure on audiogenic and amygdala kindling models of seizure
… outside the auditory brainstem using the amygdala kindling model (a well characterized model of temporal lobe epilepsy in rodents). Two males from each of the litters described above were implanted bilaterally with electrodes in the basolateral amygdala as adults. For each animal a number …
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Effects of Regional Deletion of Rab3A-interacting Molecule and PTEN on Brain Function
… interference RNA was injected into the basolateral amygdala to knockdown PTEN in local pyramidal neurons. In the case of RIM1, I hypothesized that deletion of RIM1 from the dentate gyrus or from area CA3 would replicate a subset of the learning and memory deficits found in RIM1α-/- mice. …
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The role of the amygdala in dreaming
… studies have strongly implicated the basolateral amygdala in dreaming (e.g. Maquet et al., 1996). Various neuropsychological dream theorists (Domhoff, 2001; Hobson, Pace-Schott & Stickgold, 2000; Revonsuo, 2000) propose central roles for the amygdala in dreaming (particularly in the …
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Investigating the influence of LH-projecting BLA neurons upon motivated behavioral responding and appetitive learning
… of therapies. Two neural regions, the basolateral amygdala (BLA) and lateral hypothalamus (LH), are both implicated in reward processing (Adamantidis et al., 2007; Anand and Brobeck, 1951; Brobeck, 1946; Gutierrez et al., 2011; Hoebel and Teitelbaum, 1962; Kempadoo et al., 2013; …
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Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference
… synaptic plasticity that is enhanced in the amygdala due to cocaine exposure in the Central-Basolateral Amygdala (CeA-BLA) pathway. Electrophysiology recordings showed that the dopamine agonist-induced LTP is mediated via D1 receptors and is dependent upon mGluR1 and the mGluR linked to PLD …
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Neurobiologically-motivated treatments for post-traumatic stress disorder in an animal model
… infusions of a ghrelin receptor agonist in the basolateral amygdala (BLA), a brain region involved in emotional memory and altered by stress, suggesting a direct action of ghrelin at ghrelin receptors in the BLA. Administration of a ghrelin receptor inverse-agonist concurrent with stress …
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