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Showing 1 to 2 of 2 for “"Basic-Leucine Zipper Transcription Factors"”.
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Determining protein interaction specificity of native and designed bZIP family transcription factors
… being able to disrupt their interactions. The basic leucine-zipper transcription factors (bZIPs) are a class of eukaryotic transcription factors that form either homodimers or heterodimers that bind to DNA in a site-specific manner. bZIPs are similar in sequence and structure, yet bZIP …
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Regulation of Adaptive and Innate Immunity by the Circadian Transcription Factor NFIL3
… host immunity. Here, I show that the circadian transcription factor NFIL3 is critical for both adaptive and innate immunity by regulating TH17 cells and innate lymphoid cells (ILCs), respectively. First, NFIL3 transcriptionally represses RORgt, the master regulator of TH17 cells, by directly …