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Showing 1 to 20 of 25 for “"Basic Helix-Loop-Helix Transcription Factors"”.
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Mapping of the repression domain and the subcellular localization of the ABF-1 protein
<p>Basic helix-loop-helix transcription factors play important roles in pathways that result in the formation of such tissues as skeletal muscle, the nervous system, pancreas and heart. A recently discovered B-cell restricted bHLH transcription factor activated Bcell factor 1 (ABF -1) is suspected …
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Roles of Neurogenin and Geminin in Vertebrate Neurogensis
… and geminin in vertebrate neurogenesis Proneural basic helix-loop-helix transcription factors regulate cell fate commitment and differentiation in neurogenesis. However, their proneural functions are not well understood, in part due to a lack of information about their target genes. Here, we …
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Flavonoid diversification in Hibiscus and its impact on petal pattern evolution
… comprising MYB (myeloblastosis) and bHLH (basic helix-loop-helix) transcription factors and a WD40 co-factor. I identified a gene regulatory network centred on the R2R3 MYB HtBERRY1 to regulate anthocyanin biosynthesis at the petal base of H. trionum. Within the Trionum Complex, bullseye …
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Transcriptional Regulation of Cardio-Pulmonary Development
… species. One conserved protein is dHAND, a basic helix-loop-helix (bHLH) transcription factor that is required for normal development of the right ventricle, the pharyngeal arches and limb buds. Loss of dHAND leads to apoptosis in the aforementioned tissues and to embryonic lethality at …
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Chemistry to Biology and Back Again: Small Molecule Regulation of HIF Transcription Factors and the Development of a Platform for the Discovery of New Biocatalyzed Organic Transformations
… oxygen levels in the cells are low, a family of transcription factors known as hypoxia inducible factors (HIFs) is up regulated. Importantly, the hypoxic response pathway is often mis–regulated in cancer. As a result, the regulation of this pathway offers a promising target for cancer treatment. …
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The MYC transcription factors are involved in regulating the time-of-day variations in susceptibility to Botrytis cinerea in Arabidopsis thaliana
… responses against B. cinerea. The paralogous basic helix-loop-helix transcription factors, MYC2, MYC3 and MYC4 are primary regulators of the JA pathway and have been implicated in immune responses against B. cinerea but it is not known whether any or all of these transcription factors are …
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Control of Cardiac and Limb Development by the bHLH Transcription Factors DHAND and eHAND
Members of the basic helix-loop-helix (bHLH) transcription factor family regulate the specification and differentiation of multiple cell lineages during embryonic development. The bHLH proteins dHAND and eHAND are expressed in complimentary and overlapping patterns during embryogenesis, and gene …
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Prdm13, a Direct Downstream Target of Ptf1a, Regulates the Balance of Gabaergic Neurons versus Glutamatergic Neurons in the Dorsal Spinal Cord
… (E/I balance) neurons. The combination of basic helix-loop-helix (bHLH) and homeodomain (HD) transcription factors is essential to generate the E/I balance required for correct functioning of neural networks. During dorsal spinal cord development, the bHLH factor Ascl1 is expressed in …
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Modulation of Excitatory and Inhibitory Neuronal Balance Through Regulation of Ptf1a by Factors Binding to Zinc Finger and POU Motifs
… between excitatory and inhibitory neurons. Transcription factors of the basic helix-loop-helix (bHLH) family have been shown to be particularly important in generating the correct numbers of these neurons during development. One of these, Ptf1a, is required in the specification of inhibitory …
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Neurogenesis and Gliogenesis from Ascl1 (Mash1) Expressing Progenitors in the Central Nervous System
… astrocytes in a precisely coordinated manner. Basic helix-loop-helix (bHLH) transcription factors play central roles in determining distinct neural cell fates and thus contribute to mechanisms controlling neural cell type diversity during the embryogenesis. Fundamental to understanding nervous …
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RBP-L and RBP-J Have Critical Roles in the Functioning of Two Forms of the Pancreas Transcription Factor Complex PTF1
… regulated by a complex network of signaling and transcription factor pathways. P48 is a tissue-specific basic-helix-loop-helix (bHLH) transcription factor, which is essential for pancreas development and function. Mice lacking both p48 alleles lack an exocrine pancreas and have a greatly reduced …
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The Mammalian Hypoxia Response Pathway: Regulation of HIF and HIF Prolyl Hydroxylases
… initiate an adaptive response orchestrated by a transcription factor called Hypoxia Inducible Factor (HIF). HIF is composed of an oxygen-sensitive alpha -, and an oxygen-insensitive beta -subunit (ARNT). The stability and transcriptional activity of HIF alpha are controlled by two different …
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The bHLH/PAS Transcription Factor SIM1 Is a Novel Obesity Gene
… I show that her translocation disrupts a transcription factor gene, SIM1, on chromosome 6q16.2. I also present data that Sim1 haploinsufficiency causes obesity in mice. Animals heterozygous for a Sim1 null allele fed a standard chow diet (4% fat) developed obesity around the time of sexual …
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Intrinsic Specificity of Binding and Regulatory Function of Class II bHLH Transcription Factors
… and maintain their functional characteristics. Transcription factors provide a mechanism to select tissue-specific programs of gene expression from the shared genome. ASCL1, ASCL2, and MYOD are class II basic Helix-Loop-Helix (bHLH) transcription factors which play crucial roles in lineage …
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Genome-Wide Analysis of Transcription Factors Ascl1 and Ptf1a in Development and Cancer
… the developing embryo relies on combinations of transcription factors to regulate tissue specific gene programs. Many of the same transcription factors can be found in multiple tissue types and are crucial for their development, and at other times these same factors can be misused in disease …
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Dual Mechanisms Regulating Alpha Subunit-Specific Activity in Hypoxia-Inducible Factor Signaling
… a master regulator of this response. These bHLH transcription factors enhance transcription of a variety of genes that work to maintain oxygen homeostasis and allow adaptation to decreased oxygen availability. Two homologues, HIF-1α and HIF-2α, have been extensively studied in this field. Though …
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HIF-2: Standing Guard at the Crossroads of Stress and Aging
… stress is in part mediated by stress-induced transcription factors. Hypoxia-induced mediators include transcription factors, such as the α (alpha) subunit of Hypoxia inducible factors (HIF-1alpha and HIF-2 alpha). HIF-1 alpha and HIF-2 alpha have similar structural organization, and after …
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Structural Characterization and Chemical Inhibition of the ARNT/TACC3 Complex
… focuses on mechanistic studies of a new group of transcriptional coactivators (coiled-coil coactivators: TACC3, TRIP230, CoCoA), involved in cancer development and progression. Normally, these coactivators play an essential role in the HIF hypoxia response, directly interacting with the ARNT …
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Investigating the Transcriptional Regulation of PTF1A and the Function of PRDM13 to Specify Dorsal Spinal Interneurons
Transcriptional regulation is a fundamental process required for cell fate specification. During neural development, complex interactions of diverse transcription activators and repressors regulate lineage specific programs. The multitudes of neuronal subtypes generated during development is …
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Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming
… activity of pro-neural signaling molecules and transcription factors is sufficient to induce the transdifferentiation of lineage-restricted fibroblasts into functional neurons; however, a mechanistic model of the immediate-early events that catalyze this conversion has not been well defined. We …
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