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Showing 1 to 20 of 25 for “"Basic Helix loop Helix (bHLH)"”.
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Molecular Interactions of Basic Helix Loop Helix (bHLH) Genes in Inner Ear Development
… embryogenesis. Major players in these events are basic helix-loop-helix (bHLH) genes: Neurogl, Atohl and Neurodl. We investigated whether co-expression of Neurogl and Atohl in common neurosensory precursors could explain the loss of hair cells in Neurogl null mice. Analysis of terminal mitosis, …
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Part I characterization of MyoR in C2C12 mouse fibroblasts. Part II isolation and characterization of a novel class II bHLH transcription factor from the black widow spider, latrodectus hesperus
<p>PART I</p> <p>The basic helix-loop-helix (bHLH) family of transcription factors are involved in a variety of developmental processes. MyoR is the mouse homologue of the human transcription factor ABF-1 . MyoR is classified as a class II basic-helix-loop-helix transcription factor. In order to …
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Isolation of novel ABF-1 splice forms
… represents the only member belonging to the basic helix-loop-helix (bHLH) family of transcription factors whose expression pattern is restricted to B cells. ABF-1 forms heterodirner complexes with E2A to modulate gene transcription. Here we report the isolation often novel ABF-1 splice …
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Control of Cardiac and Limb Development by the bHLH Transcription Factors DHAND and eHAND
Members of the basic helix-loop-helix (bHLH) transcription factor family regulate the specification and differentiation of multiple cell lineages during embryonic development. The bHLH proteins dHAND and eHAND are expressed in complimentary and overlapping patterns during embryogenesis, and gene …
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Evidence that ARNT plays a role in the regulation of the immunoglobulin heavy chain enhancer and identification of a putative ARNT ligand
<p>Basic helix-loop-helix (bHLH) proteins are involved in the regulation of a multitude of developmental processes including cellular differentiation, cellular proliferation and xenobiotic metabolism. Among the members of the bHLH protein family are the products of the Pan gene Pan-1, Pan-2 and ITF …
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Analysis of ASCL1 in Neuroendocrine Lung Cancer
… Previous studies have determined that the basic helix-loop-helix (bHLH) transcription factor achaete-scute homolog 1 (ASCL1) is essential for the survival and progression of many pulmonary neuroendocrine (NE) cancer cells, which include both SCLC and some non-small cell lung cancer (NSCLC). …
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Intrinsic Specificity of Binding and Regulatory Function of Class II bHLH Transcription Factors
… genome. ASCL1, ASCL2, and MYOD are class II basic Helix-Loop-Helix (bHLH) transcription factors which play crucial roles in lineage specification in the developing embryo. In vivo, these factors bind to distinct genomic sites, and regulate distinct transcriptional programs. The mechanisms by …
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The characterization of the ABF-1 promoter
<p>The basic helix-loop-helix (bHLH) family oftranscription factors consists of proteins involved in cellular proliferation and differentiation. The HLH structure plays a key role in protein-protein dimerization and with the DNA target sites, referred to as E boxes containing the consensus DNA …
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Modulation of Excitatory and Inhibitory Neuronal Balance Through Regulation of Ptf1a by Factors Binding to Zinc Finger and POU Motifs
… inhibitory neurons. Transcription factors of the basic helix-loop-helix (bHLH) family have been shown to be particularly important in generating the correct numbers of these neurons during development. One of these, Ptf1a, is required in the specification of inhibitory neurons in multiple regions …
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Characterization of Neural Stem Cells Using the Nestin Enhancer
… We also investigated that ngn1, which is a basic helix-loop-helix (bHLH) transcription factor that is expressed in neuronal precursors during development of the nervous system, can promote nestin expression by nestin enhancer located on nestin 2nd intron. Two E-boxes (CANNTG) in 637bp of the …
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Covalent modification and intrinsic disorder in the stability of the proneural protein Neurogenin 2
Neurogenin 2 (Ngn2) is a basic Helix-Loop-Helix (bHLH) transcription factor regulating differentiation and cell cycle exit in the developing brain. By transcriptional upregulation of a cascade of other bHLH factors, neural progenitor cells exit the cell cycle and differentiate towards a neuronal …
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Understanding the molecular mechanism of postharvest seed coat darkening in pinto beans
… As part of my initial research objective, a basic-Helix-Loop-Helix (bHLH) transcription factor encoding the P (Pigment) gene was identified in pinto beans. P protein in a regulator of proanthocyanidins (PAs) biosynthesis. Using genetic complementation, transcript abundance, metabolite …
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Transcriptional Regulation of Cardio-Pulmonary Development
… species. One conserved protein is dHAND, a basic helix-loop-helix (bHLH) transcription factor that is required for normal development of the right ventricle, the pharyngeal arches and limb buds. Loss of dHAND leads to apoptosis in the aforementioned tissues and to embryonic lethality at …
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Prdm13, a Direct Downstream Target of Ptf1a, Regulates the Balance of Gabaergic Neurons versus Glutamatergic Neurons in the Dorsal Spinal Cord
… (E/I balance) neurons. The combination of basic helix-loop-helix (bHLH) and homeodomain (HD) transcription factors is essential to generate the E/I balance required for correct functioning of neural networks. During dorsal spinal cord development, the bHLH factor Ascl1 is expressed in …
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RBP-L and RBP-J Have Critical Roles in the Functioning of Two Forms of the Pancreas Transcription Factor Complex PTF1
… factor pathways. P48 is a tissue-specific basic-helix-loop-helix (bHLH) transcription factor, which is essential for pancreas development and function. Mice lacking both p48 alleles lack an exocrine pancreas and have a greatly reduced endocrine pancreas. The active form of P48 is the …
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Genomic approaches to understand sweetpotato root development in relation to abiotic factors
… majority of these transcripts are involved in basic cellular processes as well as development and differentiation. A set of regulatory genes, such as BEL1-like (BELL), basic helix-loop-helix (bHLH) and HD-Zip homeobox, and signal transduction genes, such as those encoding calcium binding …
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Molecular mechanisms underlying Juvenile hormone (JH) signaling pathway
… (MET). MET is a transcription factor of the basic helix-loop-helix (bHLH)/Per-Arnt-Sim (PAS) family. In the presence of JH, MET forms a heterodimer with its DNA-binding partner Taiman (TAI). The MET-TAI complex directly binds to the regulatory regions of some JH target genes and regulates …
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Genome-Wide Analysis of Transcription Factors Ascl1 and Ptf1a in Development and Cancer
… factors can be misused in disease states. The basic helix-loop-helix (bHLH) factors Ascl1 and Ptf1a are examples of factors that give rise to and function in multiple tissues. Ascl1 and Ptf1a are essential for generating the correct number and sub-type of neurons in multiple regions of the …
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Transcriptional Regulation of Neuronal Fate Specification by Proneural Genes in the Developing Neocortex
… of cortical neurogenesis are the proneural basic helix-loop-helix (bHLH) transcription factors encoded by Neurog1, Neurog2, and Ascl1. The activities of these proneural genes are tightly regulated, ensuring that neocortical neurons are born at their correct times and with their proper …
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Transcriptional and Translational Regulation of Cardiac Progenitors in the Mouse and Zebrafish
… particular cardiac progenitor populations. The basic helix-loop-helix, bHLH, transcription factor, Hand2 has been discovered over a decade ago, and has a severe loss-of-function cardiac phenotype in vivo, yet its function is still not completely known. It is expressed in the early cardiac …
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