Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Basement membranes"”.
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Mechanisms of Type IV Collagen Targeting to Developing Basement Membranes
<p>Basement membranes (BMs) are cell-associated extracellular matrices that support tissue integrity, signaling, and barrier properties. Type IV collagen is critical for the mechanical and signaling functions of BM. However, due to the challenge of imaging of BMs in vivo, the lethal phenotypes of …
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Effect of Emb-9 and Let-2 Mutations on the Proper Assembly of Basement Membranes and on the Morphology of Body Wall Muscle Cells in Caenorhabditis Elegans
… IV is one of the most abundant components of the basement membrane composed of two α1 chains and one α2 chain secreted into the BM between muscle cells and the hypodermis early in embryogenesis. Worms homozygous for specific let-2 or emb-9 mutations show intracellular accumulation of the α2 of α1 …
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Laminins in blood vessel development and disease -functional aspects in angiogenesis, atherosclerosis, and muscular dystrophy
Basement membranes are sheet like extracellular matrices that underlie or surround many cell types. They are crucial for key cellular events such as cell migration, proliferation, survival and differentiation. Vital components of all basement membranes are laminins, heterotrimeric combinations of …
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Role of Laminin gamma 1 in Cortical Development
<p>Laminins are a major component of basement membranes, including those in the central nervous system (CNS). To explore the role of laminin γ1, a subunit common to all laminins found within the CNS, we developed a murine model in which laminin γ1 is conditionally disrupted in the nervous system. …
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Fibulin-2 Stabilizes Tumor Extracellular Matrix and Drives Malignant Progression of Lung Adenocarcinoma
… lung tumors were marked by disorganized basement membranes, dense collagen networks, and increased tissue stiffness. Metastasis-prone lung adenocarcinoma cells secreted fibulin-2 (Fbln2), a matrix glycoprotein involved in ECM supra-molecular assembly. Fibulin-2 depletion in tumor cells …
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The Comparative Ultrastructure of the Choroid Plexus in Certain Animal Species
… the frog. The Golgi apparatus consists of smooth membranes, is of typical form and is in reality a part, though a specialized one, of the endoplasmic reticulum as investigations by other authors have indicated.</p> <p>The nuclei of the cells of the choroidal epithelium are large and usually round. …
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Surface proteins of Finegoldia magna interacting with the human host
… FAF also mediates adhesion of the bacterium to basement membranes of human skin by interacting with BM-40. A further function of FAF is blocking of the activity of antimicrobial peptides. The genes encoding faf and sufA are present in a majority of investigated isolates indicating that the …
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Analysis of Β8 Integrin In Neurogenesis and Neurovascular Homeostasis
… niche, consisting of blood vessels and their basement membranes. Most NSCs in the SVZ differentiate into progenitor cells, which further differentiate to generate neuroblasts, which then migrate from the SVZ to the olfactory bulbs (OB) along the rostral migratory stream (RMS). ECM-mediated …
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An Alpha7beta1 Integrin-Based Treatment of Muscular Dystrophy
… the attachment of myofibers to their surrounding basement membranes. Two complexes that mediate such interactions in adult skeletal muscles are the alpha7beta1 integrin complex and the dystrophin protein complex. Both act as molecular chains that connect the actin cytoskeleton to laminin in the …
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Dense Collagen Materials and the Modulation of Fibrillogenesis for Tissue Engineering
… cues that synthetic materials and nylon membranes cannot reproduce. This thesis presents a platform of densified collagen scaffolds that bridges the gap between synthetic materials and living tissue. A scalable, material-based absorptive-deformation process removes interstitial water from …
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Permeability studies in biomimetic glycosaminoglycan-hydrogel membranes
… charged, fibrous agarose-glycosaminoglycan (GAG) membranes. The work was motivated by current research into the role of the glomerular capillary wall (GCW) in ultrafiltering blood plasma, which is the first step in the processing of blood by the kidney. The GCW is composed of three layers in …
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Gene expression studies of pregastrulation development: the basement membrane is essential for cell differentiation
Basement membranes (BMs) are sheet-like structures of extracellular matrix. They act as a supporting structure but can also significantly influence cellular behavior in development, tissue homeostasis and disease. Laminins, a major BM component, are multidomain proteins, consisting of three …
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The targeting of corticosteroids to inflamed tissues
… migration through disrupted endothelium and basement membranes at the inflamed sites. , .
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Characterisation of novel matrix-binding interactions for latent transforming growth factor-β-binding protein-2 (LTBP-2), with emphasis on heparin and heparan sulphate proteoglycans.
… cell surfaces as syndecans and glypicans and in basement membranes as perlecan. Full length human recombinant LTBP-2 (rLTBP-2) was expressed in 293 EBNA cells using a modified pCEP-4 vector and purified by nickel affinity chromatography. Upon validation of the purified protein using western …
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Comparative histology of human skin.
… insight into dermal structure. (v) A novel basement membrane stain was produced. Type I and type III collagen are important structural constituents of dermis and play a crucial role in wound healing. Only two traditional histological methods are thought to differentiate between them, so …
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Identifying novel roles for basement membrane-associated proteins in the adult Drosophila intestinal epithelium
… A potential source of such signals is the basement membrane, a thin extracellular matrix which underlines the basal side of all epithelia, and to which epithelial cells adhere via various receptors. Despite their ubiquity, basement membranes are understudied and there remains much to …
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Studies on the Mislocalized Exonuclease TREX1 that Causes a Systemic Vasculopathy
… with luminal narrowing and multi-laminated basement membranes in all subjects. We also propose diagnostic criteria to aid in the recognition of CHARIOT as many cases are initially misdiagnosed.</p><p>The second part of this thesis focuses on evaluating the expression of TREX1 in human brain …