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Showing 1 to 20 of 75 for “"Base-excision-repair"”.
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The Choreography of Base Excision Repair
… of DNA damage, human cells utilize DNA repair pathways such as base excision repair (BER). BER is carried out by a series of DNA repair proteins that function in a step-by-step process to identify, remove, and replace a damaged nucleotide. BER is critical to genome stability and cell …
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Base excision repair, folate deficiency and cancer
… deficiency has been reported to incapacitate DNA repair pathways and thereby affect the genomic stability. Our lab has reported previously and here again through this research that folate deficiency affects the DNA damage inducibility of base excision repair pathway. Our study shows the …
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Functional DNA repair capacity assays : a focus on base excision repair
… and understanding an individual's DNA repair capacity may enable us to predict and prevent disease in a personalized manner. Base Excision Repair (BER) is known for the recognition and repair of endogenous and exogenous mutagenic non-helix-distorting lesions produced by DNA base …
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Replication-associated base excision repair Of oxidized bases in the mammalian genome
… agents induce strand breaks and a plethora of base lesions in DNA that (except double-strand breaks) are repaired via the DNA base excision repair (BER) pathway. Four mammalian DNA glycosylases, namely, OGG1 and NTH1 in the Nth family, and NEIL1 and NEIL2 in the Nei family, with overlapping …
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Biological response to 8-oxoguanine base released during DNA base excision repair
… due to guanine’s susceptibility to oxidation. A base excision repair pathway initiated by 8-oxoguanine DNA glycosylase (OGG1) excises 8-oxo-Gua lesions from nuclear and mitochondrial DNA, releasing the free oxidized base. It is well-established that failure to repair 8-oxo-Gua can result in …
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Identifying and characterizing hereditary polyposis and colorectal cancer: Mutational signatures of defective base excision repair
Contains fulltext : 239215.pdf (Publisher’s version ) (Open Access)
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Significance of DNA base excision repair in the maintenance of mitochondrial function in Saccharomyces cerevisiae /
… respiratory dysfunction, apoptosis, and aging. Base excision repair (BER) is the major and the only certain repair pathway existing in mitochondria that is in responsible for removing and repairing various base modifications as well as abasic sites (AP sites). In this research, Saccharomyces …
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The role of base excision repair proteins in the cellular responses to the anticancer drug cisplatin
Thesis (Ph.D.)--Massachusetts Institute of Technology, Division of Bioengineering and Environmental Health, 2000.
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Development of methods to investigate poly(ADP-ribose) polymerase-1 activity and DNA base-excision repair in relation to cancer and ageing
… (FADU) assay to measure DNA strand breaks and repair. Poly(ADP-ribose) polymerase-1 (PARP-1) is involved in DNA base-excision repair and the maintenance of genomic stability, but emerges to have many more functions in cellular physiology and pathophysiology. Cellular poly(ADP-ribosyl)ation …
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The impact of folate deficiency on the base excision repair pathway: Analysis of enzyme coordination in response to dna damage and imbalanced repair
… in colon cancer. The role of folate in DNA repair, DNA synthesis and methylation reactions renders this nutrient an valuable target for studying the onset and progression of cancer. Using molecular techniques to determine gene and protein expression, enzyme activity and methylation status …
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Somatic expansion of premutation alleles and the role of the mismatch repair and base excision repair proteins on repeat expansion in a mouse model of the fragile X-related disorders
… male and female mice in the levels of the DNA repair proteins that had already been implicated in repeat expansion in model systems of other disorders thought to arise via a similar mechanism. Neither were there any differences between males and females in the amounts of proteins produced from …
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The iron-dependent cyanide and hydrogen peroxide co-toxicity in Escherichia coli and its catastrophic consequences for the chromosome
… kill invading microbes. We also showed that the base excision repair pathway plays the major role in preventing this catastrophic chromosomal fragmentation, which indicates that the double-strand breaks induced by CN + H2O2 are preceded by a significant number of base modifications, removed by …
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Mechanism of Mismatch Repair Induced Mutagenesis in Somatic Hypermutation
… is initiated by the conversion of G:C base pairs to G:U lesions by the enzyme activation induced cytosine deaminase. Left unrepaired, G:U lesions will give rise to transition mutations at G:C base pairs, but are converted to transition and transversion mutations at G:C and A:T base …
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ENZYME-LIKE DNA CATALYST DESIGN
… first reviews the promise and limitations of DNA-based catalysis: although DNA offers chirality, structural programmability, aqueous compatibility, and sustainability, existing systems are often limited by difficult catalyst construction, narrow Lewis-acid-centered reaction scope, and unclear …
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Triplex dna receptor-gold nanoparticle conjugates for detection of oxidized dna base
Oxidations of DNA nucleobases are believed to be one of the sources of aging and some age-dependent disease, such as cancer. Human body have various mechanisms to repair damaged DNA and base-excision-repair is one mechanism for removing those oxidized nucleobases. This mechanism processes in the …
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DNA alkylation repair deficient mice are susceptible to chemically induced Inflammatory Bowel Disease
… and rectum. It is thought that cancer risk is based on chronic inflammation of the gastrointestinal mucosa. There have been many studies, which have supported this idea and have made progress toward understanding the link between chronic inflammation and cancer. In both UC and CD, it is known …
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Mitotic homologous recombination at engineered repeats in S. cerevisiae and in novel transgenic mice
… recombination provides an efficient means for repairing and tolerating DNA damage, mitotic recombination between misaligned sequences can lead to loss of genetic information (e.g. deletions, translocations and loss of heterozygosity). Given that such genetic changes may promote tumorigenesis, …
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Using the Cre-loxP system to randomize target gene expression states and generate diverse phenotypes
… the role of 4 different enzymes involved in base excision repair in tolerance to methyl methane sulfonate (MMS), a genotoxic DNA alkylating agent. The set of vectors developed here can be used to randomize the expression of both heterologous genes and endogenous genes, and could immediately …
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Effect Of Dietary Folate Restriction On Colon Carcinogenesis In Dna Polymerase β Haploinsufficient Mice
… is central to establishing the role that the base excision repair pathway (BER) plays in the development and progression of colon cancer when dietary folate is deficient. Both cellular folate restriction and BER deficiencies have been shown to result in the accumulation of endogenous damage …
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