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Showing 1 to 20 of 89 for “"Base pairing"”.

  1. Theoretical And Experimental Studies Of Noncovalent Metal Cation Binding And Base Pairing Interactions Of Cytosine And Modified Cytosines

    Yang, Bo2014

    … STUDIES OF NONCOVALENT METAL CATION BINDING AND BASE PARING INTERACTIONS OF CYTOSINE AND MODIFIED CYTOSINES</p> <p>by</p> <p>BO YANG</p> <p>December 2014</p> <p>Advisor: Professor Mary T. Rodgers</p> <p>Major: Analytical Chemistry</p> <p>Degree: Doctor of Philosophy</p> <p>Binding of metal …

    wayne-thes Repository record

  2. Ab Initio Treatment of Complex Systems Kohn-Sham Orbitals for Multi Reference Methods and the Base Pairing Properties of Xanthine

    Hupp, ThomasUniversität Würzburg

    … untersucht die Paarungseigenschaften der Purinbase Xanthin. Es wird unter anderem die unerwartet hohe Stabilität der Xanthin Selbstpaarung in Alanyl-PNA erklärt und es wird untersucht, auf welche Weise Xanthin in der DNA mutagene Fehlpaarungen mit Thymin eingehen kann. Teil1: Im Unterschied zu …

    wurz-thes Repository record

  3. Mechanistic and physiological insights into post-transcriptional regulation by small RNAs SgrS and DicF

    Balasubramanian, DivyaUniversity of Illinois at Urbana-Champaign2014

    Base pairing small regulatory RNAs (sRNAs) are important post-transcriptional regulators of gene expression in bacteria. These sRNAs deploy novel mechanisms to regulate mRNA targets leading to various physiological outcomes during stress conditions including, but not limited to, iron starvation, …

    uiuc Repository record

  4. MicroRNAs in cellular transformation and tumorigenesis

    Kumar, Madhu S. (Madhu Sudham)Massachusetts Institute of Technology2009

    … RNAs (mRNAs), largely through their imperfect base pairing with the 3' untranslated regions (3' UTRs) of these target transcripts. Through this imperfect base pairing, miRNAs induce a repression of mRNA translation that is frequently coupled to enhanced turnover of the targeted transcript. This …

    mit Repository record

  5. Distinguishing features of guide and substrate RNA recognition by H/ACA snoRNPs

    Kelly, Erin Katelyn, University of Lethbridge. Faculty of Arts and ScienceLethbridge, Alta. : Universtiy of Lethbridge, Department of Chemistry and Biochemistry2018

    … but non-specifically in vitro. Additionally, the base-pairing between guide and substrate RNA varies widely in nature. To elucidate substrate selection rules, I systematically altered the sequence of a substrate RNA and tested for snoRNP binding and activity. All substrate RNA variants tested are …

    lethbridge Repository record

  6. INVESTIGATING THE COMPETITION BETWEEN COMPONENTS OF DUAL-FUNCTION RNA

    Aoyama, Jordan James Masuo2021

    … enzyme in glycerol catabolism, while the RNA base pairs with and represses galE mRNA, a gene essential for galactose metabolism. The second dual-function RNA studied in this work is Spot 42, a 109-nucleotide RNA known to base pair with and repress mRNAs encoding proteins involved in the …

    maryland Repository record

  7. Thermodynamics and kinetics of antisense oligonucleotide hybridization to a structured mRNA target

    Walton, S. Patrick (Stephen Patrick), 1973-Massachusetts Institute of Technology2002

    … of any gene with a known sequence. Antisense-based therapies are under development for the treatment of infectious diseases as well as complex genetic disorders. Although there have been some remarkable successes, realizing this potential is proving difficult because of problems with …

    mit Repository record

  8. Interaction of the Neurospora crassa mitochondrial tyrosyl-tRNA synthetase with group I intron RNAs

    Myers, Christopher AllanThe University of Texas at Austin2002

    … of the group I intron core. P7 is a long-range base-pairing interaction of the P3-P9 domain that forms the binding site for the splicing co-factor guanosine. My results show that CYT-18 can suppress numerous mutations that impair the self-splicing of the td intron, including mutations that …

    texas Repository record

  9. Consequences of Oxidative DNA Damage: Base-Pair Dissociation, Singlet Oxygenation and DNA-Protein Crosslinking

    Moe, May MyatThe Graduate School and University Center of The City University of New York2025

    … with complementary cytidine (C) in Watson Crick base-pairing within duplex DNA. The WC-OG·C lesion, if not recognized or repaired, not only leads to G⋅C→T⋅A transversion mutations (through Hoogsteen (HG) base pairing of OG⋅A), but also renders the base pair being more vlunerable to ionizing …

    cuny-grad Repository record

  10. Effects of a carcinogenic alkyl lesion on DNA: A structural study by x-ray crystallography

    Mahalingam, SriramUniversity of Illinois at Urbana-Champaign2011

    … A resolution. The two independent $\rm e\sp6G$:C base pairs in the DNA duplex adopt different base pairing schemes. A bifurcated base-pair configuration of $\rm e\sp6G$:C with three-centered hydrogen bonds mimicking a Watson-Crick pairing, a wobble configuration, as well as a ""reverse wobble"" …

    uiuc Repository record

  11. Hydrogen Bond Template-Directed Synthesis of Recognition-Encoded Melamine Oligomers

    Evans, OliverUniversity of Cambridge2025

    The directed evolution of biopolymers is based on the mutagenic replication of DNA. However, reliance on DNA limits the application of directed evolution to molecules that can be encoded by DNA, such as proteins. The development of a synthetic oligomer which can mutagenically replicate could unlock …

    cambridge Repository record

  12. Lesion Bypass of N2-ethylguanine by the Human Y Family DNA Polymerases Iota and Kappa

    Pence, MatthewWake Forest University2009

    … evidence that the DNA pol ι utilizes Hoogsteen base-pairing as an efficient mechanism for nucleotide incorporation opposite N2-ethylGua. Comparisons between the N2-ethylGua containing structures of DNA pol ι and wild-type structures (PDB ID: 2ALZ and 2FLP) reveal that movements in a loop region …

    wfu Repository record

  13. Pan-Cancer Analysis of Non-Coding Driver Mutations

    Shuai, Shimin2019

    … recurrent A>C somatic mutation at the third base of U1 spliceosomal RNA across several tumour types. This mutation changes the preferential A-U base-pairing between U1 and 5′ splice site to C-G base-pairing, thereby creating novel splice junctions and altering the splice pattern of multiple …

    toronto-retro Repository record

  14. The evolutionary impacts of secondary structures within genomes of eukaryote-infecting single-stranded DNA viruses

    Muhire, Brejnev MuhiziInstitute of Infectious Disease and Molecular Medicine2015

    Secondary structures forming through base-pairing in virus genomes have been proven to regulate several processes during viral replication cycles, including genome replication, transcription, post-transcriptional activities, protein synthesis, genome packaging, generation of viral sub-genomes and …

    cape-town Repository record

  15. Understanding microRNA targeting with high-throughput biochemistry

    McGeary, Sean E.(Sean Edward)Massachusetts Institute of Technology2021

    … level. miRNA repression occurs primarily through base-pairing between the miRNA seed region (nucleotides 2-8) and mRNA 3'-UTR sites, leading to transient recruitment of mRNA-destabilizing factors. However, only a small fraction of the gene-expression changes caused by a miRNA can currently be …

    mit Repository record

  16. Investigating Hfq-Mrna Interactions In Bacteria

    Faner, Martha Audra2013

    … of their target mRNAs through complementary base-pairing. The base-pairing interaction is not perfect and requires the action of an RNA binding protein, Hfq. Hfq facilitates these RNA-RNA interactions by stabilizing duplex formation, aiding in structural rearrangements, increasing the rate of …

    wayne-thes Repository record

  17. Synthesis and Spectroscopic Studies of Substituted Pyrrolocytidines

    Charles, McKenryThe University of Western Ontario2013

    … in nucleic acid chemistry. These heterocyclic base surrogates that are capable of canonical base pairing have use in the study of nucleic acid conformation, as reporters of the state of hybridization.[1] The synthesis of a 5-phenylpyrrolocytidine was attempted in order to compare its properties …

    uwo Repository record

  18. Novel Algorithms for Structural Alignment of Non-coding RNAs

    Kolbe, Diana2010

    … by their secondary and tertiary structures. Base-pairing interactions, particularly at the secondary structure level, are an important tool for identifying and studying these structural RNAs, but also present some unique challenges for sequence analysis. Probabilistic covariance models are …

    wustl Repository record

  19. Computational insights into the molecular basis for the replication of flexible tobacco-derived DNA lesions

    Wilson, Katie A., University of Lethbridge. Faculty of Arts and ScienceLethbridge, Alta. : University of Lethbridge, Department of Chemistry and Biochemistry2018

    … to study the intrinsic conformational and base-pairing preferences of flexible O6-G and O2-T alkyl DNA lesions, and the corresponding properties within DNA duplexes and polymerase active sites. Specifically, the replication of O6-benzylguanine (Bz-G) by a prototypical DNA polymerase, DNA …

    lethbridge Repository record

  20. Role of TLS Polymerases in Replication of DNA Lesions in Human Cells

    Conde Fabela, Juan AThe University of Texas Medical Branch at Galveston2021

    … methyl halides. They might interfere with base pairing and are cytotoxic. The long-term goal is to understand the mechanisms by which replication through such ubiquitous lesions occurs in human cells. Tumorigenesis is a multistep process associated with accumulation of mutations. …

    utmb Repository record

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