Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Base modification"”.
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Adsorptive Immobilisierung von Kollagen Typ I an Titanoxidoberflächen
… composition of the implants in particular the modification with biological components. Collagen is the main component of bone and is therefore an interesting substance for the base modification of titanium implants. The aim of the work was to investigate the adsorptive immobilisation of …
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The Role of Base Modifications on Tyrosyl-tRNA Structure, Stability, and Function in Bacillus subtilis and Bacillus anthracis
… more than 80 chemically unique nucleotide base modifications that contribute to the chemical and physical diversity of RNAs as well as add to the overall fitness of the cell. For instance, base modifications have been shown to play a critical role in tRNA molecules by improving the fidelity …
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The KsgA methyltransferase: Characterization of a universally conserved protein involved in robosome biogenesis
… process, involving numerous cleavage, base modification and assembly steps. All ribosomes share the same general architecture, with small and large subunits made up of roughly similar rRNA species and a variety of ribosomal proteins. However, the fundamental assembly process differs …
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Establishing new approaches to unveil regulatory functions of tRNAs and their interactors
… to the variability in tRNA sequence and base modification. Here, a novel tRNA-seq. method was devised to accurately quantify the tRNAome and outline the modification and truncation landscapes, allowing to query the concerted response of tRNAs across conditions. The method was then applied …
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High-resolution mapping of abasic sites and pyrimidine modifications in DNA
… damage products. Abasic sites occur when a nucleobase is lost from DNA by hydrolysis and can lead to mutations and genomic instability. This thesis focuses on the development and application of methodology to map the location of abasic sites in DNA by next-generation sequencing. Chemically, abasic …
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Characterizing novel molecular regulators of antiviral gene expression
… regulatory controls is the RNA base modification N6-methyladenosine (m6A), which regulates many aspects of mRNA metabolism through transcript-specific effects. m6A deposition is mediated by a cellular complex of proteins including METTL3 and METTL14 (METTL3/14) and other …