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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Base excision repair (BER)"”.
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Mitotic homologous recombination at engineered repeats in S. cerevisiae and in novel transgenic mice
… recombination provides an efficient means for repairing and tolerating DNA damage, mitotic recombination between misaligned sequences can lead to loss of genetic information (e.g. deletions, translocations and loss of heterozygosity). Given that such genetic changes may promote tumorigenesis, …
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Folate Deficiency and Its Effect On Dna Repair
… on cancer prevention has been examined in a number cellular and epidemiological studies, yet unanswered questions remain. For example, recent studies raised questions regarding the timing of folic acid supplementation. High folate status tends to have a protective effect against cancer and low …
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Significance of DNA base excision repair in the maintenance of mitochondrial function in Saccharomyces cerevisiae /
… respiratory dysfunction, apoptosis, and aging. Base excision repair (BER) is the major and the only certain repair pathway existing in mitochondria that is in responsible for removing and repairing various base modifications as well as abasic sites (AP sites). In this research, Saccharomyces …
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NQO1-Bioactivatable Drugs at the Interface of Cancer Metabolism and the DNA Damage Response
… radical to induce extensive DNA oxidative base damage, single strand breaks and poly(ADP-ribose) polymerase 1 (PARP1)-driven depletion of intracellular NAD+. However, tumor cell NADPH and glutathione (GSH) biogenesis can attenuate the efficacy of this class of drugs by blunting the ROS …
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Role of inherited DNA repair deficiencies in cancer susceptibility and evolution
Multiple DNA surveillance and repair mechanisms act on the human genome, maintaining high replication fidelity and genome stability. Deficiencies in these processes result in an accumulation of post-zygotic mutations with characteristic signatures. This genomic instability is associated with the …
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Exploring the biological functions of AlkB proteins and how they relate to AAG
… Fortunately, our cells have evolved DNA repair mechanisms to maintain genomic integrity against this constant attack. An important type of DNA damage is alkylation damage, which has been the focus of this thesis, the major goal of which is to explore the biological role of a set of …
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Altered DNA Repair, Antioxidant and Cellular Proliferation Status as Determinants of Susceptibility to Methylmercury Toxicity in Vitro
… molecular mechanisms remain largely unclear. Base excision repair (BER) is important in mitigating the pathogenic effects of oxidative stress, which has also been implicated in the mechanism of MeHg toxicity, however the importance of BER in MeHg toxicity is currently unknown. Accordingly, we …
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RAD51-MEDIATED ABASIC SITES PROTECTION PREVENTS REPLICATION FORK COLLAPSE.
… AP sites on double-stranded DNA are primarily repaired by the base-excision repair (BER) pathway. However, AP sites that escape BER can be cleaved by endonucleases, causing as result DNA single-strand or double-strand breaks. These DNA breaks can further increase genomic instability and …
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RESPONSE OF A NEIL1 DEFICIENT MURINE EPITHELIAL CELL LINE TO CHROMATE
… exposed to oxidants which can lead to nucleobase damage. Chromium is of particular interest as a DNA oxidant because of its abundance in the environment and the ease with which it can be taken into a cell. Chromate, Cr(VI), ions are taken up by a cell through relatively non-selective anion …
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RESPONSE OF A NEIL1 DEFICIENT MURINE EPITHELIAL CELL LINE TO CHROMATE
… exposed to oxidants which can lead to nucleobase damage. Chromium is of particular interest as a DNA oxidant because of its abundance in the environment and the ease with which it can be taken into a cell. Chromate, Cr(VI), ions are taken up by a cell through relatively non-selective anion …
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Clarifying the Role of the CST Complex in DNA Replication and Repair
… These structures are protected by a number of essential protein complexes including the shelterin complex and CST (CTC1 – STN1 – TEN1) complex. CST is an RPA-like ssDNA binding protein that is vital for telomere length maintenance via inhibition of telomerase and stimulation of DNA …
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Intracellular antioxidant and DNA repair enzymes as correlates of stress resistance and longevity in vertebrates
… perhaps key antioxidant enzymes as well as DNA repair enzymes. Enhanced antioxidant and DNA repair capacities may underlie the enhanced cellular stress resistance observed in long-lived animals, however little data is available that directly supports this idea. I used three. experimental …
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Functional DNA repair capacity assays : a focus on base excision repair
… and understanding an individual's DNA repair capacity may enable us to predict and prevent disease in a personalized manner. Base Excision Repair (BER) is known for the recognition and repair of endogenous and exogenous mutagenic non-helix-distorting lesions produced by DNA base …
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DNA Repair Mechanisms, Aflatoxin B1-Induced DNA Damage and Carcinogenesis
… thesis investigated the relationship between DNA repair mechanisms, aflatoxin B1 (AFB1)-induced DNA damage and carcinogenesis. Mice deficient in 8-oxoguanine glycosylase (OGG1, the rate-limiting enzyme in repair of oxidized guanine), mice heterozygous for OGG1, and wild type mice, were exposed to …
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Mechanism of Incorporation and Repair of Uracil At Highly Transcribed Genes In Saccharomyces Cerevisiae
… or Abasic (AP) sites derived from uracil excision, accumulate at a higher rate in actively transcribed regions of the genome in S. cerevisiae and are primarily repaired by base excision repair (BER) pathway. I have demonstrated that transcription-coupled nucleotide excision repair (NER) …
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The Choreography of Base Excision Repair
… of DNA damage, human cells utilize DNA repair pathways such as base excision repair (BER). BER is carried out by a series of DNA repair proteins that function in a step-by-step process to identify, remove, and replace a damaged nucleotide. BER is critical to genome stability and cell …
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Targeted Inactivation of APE1 Endonuclease by E96A Mutation Sensitizes Pancreatic Ductal Adenocarcinoma to DNA-Damagin Therapy
… PDAC cells to persistent DNA damage, making DNA repair pathways essential for tumor survival. Apurinic/apyrimidinic endonuclease 1 (APE1/Ref-1) is a multifunctional protein with critical roles in base excision repair (BER) and redox regulation of transcription factors. This dissertation tests the …
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XRCC1 & DNA MTases : direct and indirect modulation of inflammation-induced DNA damage
… potentiate malignancy. We hypothesize that the base excision repair (BER) pathway modulates susceptibility to malignancy, by modulating the BER-intermediate levels, large scale genomic rearrangements and toxicity following exposure to RONs. We further hypothesize that DNA methyltransferases are …
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Investigation into the role of DNA damage and repair during influenza infection and inflammation
… The accumulated damage, e.g. strand breaks and base lesions, can lead to mutations, cell death, and cancer if not repaired efficiently. To protect genome integrity, organisms have evolved multiple DNA repair processes. A deeper comprehension of DNA damage and repair during disease pathogenesis …
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Alkyladenine DNA glycosylase (Aag)-dependent cell-specific responses to alkylating agents
… components, including our DNA. If left unrepaired, methylated DNA can cause mutations, cell death, and disease, such as cancer and neurodegeneration. The majority of DNA lesions caused by methylating agents are repaired by the base excision repair (BER) pathway, which is initiated by the …
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