Global ETD Search
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Showing 1 to 11 of 11 for “"Base change"”.
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cdh descent for homotopy Hermitian K-Theory of rings with involution
… that the representing spectrum is stable under base change, and cdh descent for homotopy Hermitian K-theory of rings with involution is a formal consequence.
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Transgenic complementation of rumpshaker with wild type proteolipid protein
… 2(SPG2) in man (Hudson et al., 2004). A single base change mutation in our spontaneous mouse model rumpshaker (Plpjp-rsh)(Ile186Thr) (Schneider et al., 1992) generates a misfolded protein resulting in dysmyelination and increased numbers of apoptotic oligodendrocytes. The phenotype varies from …
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Base editing of Galactose-1-Phosphate Uridylyl Transferase as a novel gene therapy approach to treat Q188R mutation in a cellular model of Classic Galactosemia
… galactitol. The Q188R mutation is caused by a base change from adenine to guanine in base pair 563. This mutation causes an amino acid change in position 188 from glutamine (Gln) to arginine (Arg) and is responsible for 60-70% of CG cases in homozygous state. Consequently, affected infants …
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Self-intersection of Manin-Drinfeld Cycles and Taylor expansion of L-functions
… which showed that higher derivatives of the base change L-function of an unramified automorphic representation over PGL₂ over a function field are equal, up to a constant, to the self-intersection number, inside the moduli stack of PGL₂-shtukas, of the moduli stack of shtukas for an …
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The Taylor-Wiles method for reductive groups
… results concerning existence of global cyclic base change and the possible finite images of automorphic Galois representations. The main technical difficulty is in proving an instance of local-global compatibility at certain level structures deeper than parahoric level, which we require for our …
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Level raising for automorphic representations of GL(2n)
… this is possible, after replacing $\Pi$ with its base change along a CM biquadratic extension, under certain assumptions on $\Pi$ (including a local obstruction at the place $w$). Our proof uses the results of Kaletha, Minguez, Shin and White on the endoscopic classification of representations of …
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Analysis of the Function of Megf7 During Development
… of syndactyly in cows, is caused by a single base change at the exon/intron border of exon 37 of bovine Megf7. in vivo and in vitro data suggests that this mutation leads to altered splicing of the gene and premature truncation of the translated gene product. The other six mutant mouse alleles …
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Molecular genetic investigation of autosomal dominant muscular dystrophy
… polypeptide 7 gene (MYH7), identified seven base changes between the MPD1 proband sequence and the published MYH7 eDNA sequence. All of these base changes were found in eight unrelated, unaffected Western Australians, therefore none of them were the Laing myopathy mutation. Two further …
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The Oncogene of Avian Sarcoma Virus UR2 and its Cellular Homologue: Structure, Sequence and Expression
… tyrosine kinases and it has unique amino acid changes and insertions within the conserved domain of the kinases. I also determined the sequence of cellular ros and compared it to viral ros to determine the changes between them that may be responsible for their differential oncogenicity; in …
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Molecular genetics of triazine resistance in Senecio vulgaris L
… gene consisted of an open reading frame of 1062 base-pairs. The nucleotide and deduced amino acid sequences were highly homologous to other published higher plant psbA sequences. Consistent with the results of the BstXI digestion results, an A -> G base change distinguished the resistant gene …
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Role of two genes, CACNA1D and CADM1, with common or rare mutations in aldosterone producing adenomas of the adrenal.
… by whole exome sequencing, over 30 single-base change mutations have been reported in the CACNA1D gene, which encodes the a1 subunit of an L-type Ca2+ channel (LTCC), CaV1.3. Initial and several subsequent mutations cause electrophysiological gain-of-function with increased activation …