Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Basal-like breast cancer"”.
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IGF2 Promotes Activation of Estrogen Receptors in Basal-like Breast Cancer Cells
… in the growth and differentiation of normal breast. In breast cancer (BC), IGF2 is initially stimulated by estrogen, progesterone and prolactin to regulate proliferation and cancer progression. These actions are mediated by the IGF-1R and insulin receptor A (IR-A) both members of the …
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Basal-like breast cancer: modeling its initiation and characterizing novel EGFR variants
Breast cancer (BC) is now a disease that will affect 1 out of every 8 women worldwide. Due to its highly heterogeneous nature, BC is usually further classified into different subtypes according to gene expression profiling analysis. Basal-like breast cancer (BBC) accounts for 15-20% of all cases of …
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The chemokine CCL2/CCR2 signaling mediates cancer associated fibroblasts-cancer cells interaction and promotes basal-like breast cancer progression
Breast cancer is the most common cancer diagnosed in women in the United States. The basal-like breast cancer subtype represents about 12% of breast cancer and has the worst outcome in patients due to lack of effective therapies. Tumor stroma plays an important role in cancer progression. Cancer …
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Role of RIP3 in DNA damaging agent-induced breast cancer cell death
… agents and contributes to chemotherapy-induced breast cancer cell death. However, we also show that RIP3 expression is silenced in basal like breast cancer cell lines due to DNA methylation near its transcription start site. Due to this silencing mechanism, loss of RIP3 expression in these cells …
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Placental co-transcriptional activator Vestigial-like 1 (VGLL1) drives tumorigenesis via increasing transcription of proliferation and invasion genes
<p>Vestigial-like 1 (VGLL1) is a co-transcriptional activator that binds to TEA domain containing transcription factors (TEADs). Its expression is upregulated in a variety of aggressive cancer types, including pancreatic and basal-like breast cancer, and increased transcription of VGLL1 is strongly …
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Molecular Analysis of Breast Cancer Transcriptomes, Genomes, and Circulating Tumor DNA
Breast cancer is a very heterogeneous disease in terms of clinical characteristics, genetic aberrations and prognosis. In Paper I, we focused on the CD44 molecule that often is aberrantly expressed in breast cancer and is widely used as a marker for cancer stem cells. Several isoforms of the CD44 …
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Intrinsic subtypes and prognostic implications in epithelial ovarian cancer
Ovarian cancer is the seventh most common cancer in women globally, with approximately 240,000 new cases annually. Although a rare disease, it is the most lethal gynecologic malignancy. Unspecific symptoms result in late diagnosis and a generally poor prognosis. However, ovarian cancer is a …
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Define The Epigenetic Profiles and Subtype-Specific Genes of Breast Cancer
… profiling has identified 5 distinct subtypes of breast cancer, luminal A, luminal B, HER2-enriched, basal-like, and claudin-low breast cancer. These 5 subtypes correlate with hormone response, patient prognosis, and response to therapy. Although steady state gene expression patterns have been …