Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Basal Subtype"”.
-
Probing the Molecular Requirements for Breast Cancer Cell Motility
… fibroblasts can induce invasion of motile basal-subtype breast cancer cells better than non-motile luminal subtype breast cancer cells. Based on these observations, the intrinsic motility of breast cancer cells was the determinate for invasion. To discover novel regulators of motility, we …
-
Targeting the Urokinase Plasminogen Activator System Combined with Chemotherapy-a Potentially Novel Therapeutic Approach for Pancreatic Cancer
… upregulation is particularly prominent in the basal subtype of PDAC, which has a high mortality rate. We then focused on the effects of selective uPA inhibition with BB20-30F, both individually and in combination with Gemcitabine, using orthotopic xenograft models that mimic early and advanced …
-
Androgen Receptor: A Complex Therapeutic Target in Breast Cancer
… breast cancer to an intermediate ER/AR-positive basal subtype, whose growth was inhibited by AR antagonists or JAK/STAT inhibitor. Treatment with a JAK inhibitor also re-sensitizes the resistant cells to AR agonists.</p> <p>While we show that AR can shift from tumor suppressor to an oncogene in …
-
Genomic Drivers of Cutaneous Squamous Cell Carcinoma Development
… cuSCC is also similar to lung SCC as well as basal subtype of breast cancer. Our cross species analysis has identified key genomic drivers of cuSCC development as potential chemoprevention targets and suggests that our model can serve as the basis for validating chemoprevention targets in …