Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 68 for “"Barrier integrity."”.
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NS1 of H5N1 Interacts with SAP-97 in a PDZ-dependent Manner to Disrupt Epithelial Barrier Integrity
… NS1 and SAP-97 results in the loss of epithelial barrier function. This mechanism helps to explain why the two disease states, pulmonary edema and diarrhea, in which epithelial barrier is compromised, are both common in human H5N1 infection.</p>
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The Tissue Specific Role of Endosome Associated Protein SNX27 in Colonic Inflammation and Tumorigenesis
… disorders remains to be unexplored. Epithelial barrier integrity, regulated by junction proteins, is critical for the maintenance of intestinal tissue homeostasis. Weakening of the intestinal barrier thus promotes susceptibility towards intestinal disorders, such as IBD and CRC. Many junction …
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Local effects of Linoorbitides and enterolactone On intestinal epithelial functions
… We first assessed LOBs and ENL effects on barrier integrity (a pathological hallmark of IBD) in vitro using a monoculture transwell system, and the potential mechanisms involved in maintenance of the barrier. Next, we examined their effect in a coculture system that more closely simulates …
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Molecularly Targeted Nanoparticles for Modulation of Inflammatory Mediators in Atherosclerosis
… an inverse relationship between endothelial barrier integrity and propensity for thrombosis. We show that increased exposure of an atherosclerotic animal to an inflammatory stimulus (e.g. cholesterol) over time decreases endothelial barrier integrity and increases hypercoagulability, however …
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hiPSC-Derived Cerebral Small Vessel Disease Models
… is yet to be known. We hypothesise that the integrity of the blood brain barrier (BBB) is disrupted and could contribute to increased BBB permeability. Evidence also shows a role of the extracellular matrix (ECM) in the progression of cSVD pathology. We generated *in-vitro* co-culture models …
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The role of Dietary Interventions in Broiler Intestinal Health and Immunity
… mucus layer serves as an essential innate barrier to pathogenic adhesion and subsequent infection. Dysregulation in the integrity or function of the mucosal layer has been implicated in malabsorption, leading to reduced animal productivity. The objective of the work described in this thesis …
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Development Of Bioelectronic Sensors For Real Time Monitoring Of Gastrointestinal Health
… biomarkers associated with GI function, such as barrier integrity, motility and enteric nervous system activity. The rising prevalence of GI diseases, driven by factors such as dietary changes, aging populations, and environmental influences, further highlights the importance of advancing GI …
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Impact of dietary fiber and exogenous carbohydrases in weaned pigs
… may be partly due to enhanced small intestinal barrier integrity and reduced local and systemic markers of inflammation. The improved ileal barrier integrity in the ileum and decreased cecal total VFA concentration in EB suggests that EB addition shifts fiber degradation from the hindgut to the …
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Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract
… during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly. Depletion of Th17 cells from the gut mucosa during HIV infection has been suggested to contribute to elevated microbial translocation and immune activation. The role of Th17 cells in …
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Microvascular endothelial response to cocaethylene exposure: morphological and molecular observations
… would result in dysregulation and altered barrier function due to changes in intracellular second messengers and signaling. To test this hypothesis, an in vitro model of CE exposure in human dermal microvascular endothelial cells (HMEC-1) was developed. Four Aims were designed to …
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The Syndecan-1 Paradox in HSV-1 Infection and Pathogenesis
… viral entry and dissemination, epithelial barrier integrity, and the resolution of inflammatory responses. Syndecan-1 (SDC1), a major heparan sulfate chain-bearing proteoglycan, traditionally characterized as a primary attachment receptor that facilitates HSV-1 binding and entry through its …
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Signaling Induced by Inflammatory Mediators in the Rodent Pulmonary Microvasculature
… pathology of ALI/ARDS by increasing endothelial barrier dysfunction. Many inflammatory mediators dictate the course and gravity of the response by inducing endothelial cytoskeletal reorganization, such as induction of actin stress fibers, cell rounding and contraction, and dissociation of …
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Integrity of the Barrier Epithelium in Drosophila Gut is Mediated by Factors That Regulate Intestinal Stem Cell Activity
… specific regulatory genes, and proposing gut barrier function–specific genes as regulators of commensal bacteria density. The results from this project have shown that intestinal stem cells (ISCs) respond systemically in the presence of autonomously induced, visceral muscle (VM)-localized …
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Unravelling the impact of pesticides on the microbiota-gut-brain axis
… in neuroimmunity, neurotransmission, blood-brain barrier integrity, fatty acid signalling, and neuroplasticity, suggesting potential systemic impacts beyond the gut microbiota. Extending our investigation beyond herbicides, we evaluated the effects of the fungicide tebuconazole and the insecticide …
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The role of the gut microbiota in the function and integrity of brain barriers
The barriers of the brain help maintain an optimal environment for central nervous system (CNS) function and homeostasis. There are many instances such as during age related disorders and neuropsychiatric disorders in which these barriers are under threat. Importantly, the gut-microbiota can …
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Acute Neuropathological Alterations after Smoke Inhalation Injury, with and without Skin Burn
… changes in the brain and loss of blood-brain barrier integrity resulting in dilated and congested blood vessels and micro-hemorrhaging. These findings provide important information that can be used to develop effective and novel treatment options for patients with smoke and burn injuries aimed …
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Determinants of systemic treatment response in atopic dermatitis
… heterogeneous pathophysiology involves epidermal barrier dysfunction, immune dysregulation, and alterations of the skin microbiome. Despite major advances through targeted therapies, predictors of individual treatment response remain poorly defined. This thesis investigates systemic therapies for …
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Targeting Endothelial Pathological Calcium Signaling Accelerates Resolution of SARS-CoV-2-Induced ARDS
… identifies endothelial dysfunction and vascular barrier disruption as central drivers of ARDS pathogenesis, particularly in the context of SARS-CoV-2 infection. This thesis investigates the role of microtubule-associated End Binding Protein 3 (EB3) in regulating pathological calcium signaling and …
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Computational Modeling of Claudin-15 Paracellular Channels
… curvature and branching while maintaining barrier integrity. A validated reduced pore model enabled extensive simulations across ionic conditions and voltages, establishing that octameric pores form via overlapping tetramers. Residue D55 functions as the core electrostatic selectivity …
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Long-Term T Cell Responses in the Ischemic Brain
… Following ischemic injury, blood-brain barrier integrity is disrupted and multiple inflammatory cascades are initiated both in the central nervous system and in the peripheral immune system. These early inflammatory responses result in the recruitment of systemic immune cells into the …
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