Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 30 for “"Barrier Dysfunction"”.
-
Skin barrier dysfunction in common genetic disorders
… of the skin is the formation of an effective barrier to prevent desiccation as well as to keep out foreign pathogens and allergens. This is a tightly regulated process and involves many structural proteins, lipids, enzymes and biochemical components. One of the proteins that has an …
-
Role of Myosin Light Chain Kinase in Binge Ethanol and Burn Injury-Induced Intestinal Barrier Dysfunction
… injury has been shown to decrease intestinal barrier function greater than either insult alone. Long (210 kDa) smooth muscle myosin light chain kinase (MLCK), an enzyme important for epithelial tight junction maintenance, has been implicated in barrier alterations after burn injury or ethanol …
-
Evaluation of cerebrospinal fluid biomarkers of endothelial damage and basement membrane degradation as indirect indicators of blood-brain barrier dysfunction in chronic canine hypothyroidism
… have shown that there is loss of blood brain barrier (BBB) integrity in these animals. Current research has also shown the development cerebrospinal fluid abnormalities in neurologically normal hypothyroid dogs; a finding that is related to BBB degradation. This derangement may be secondary to …
-
Role of Occludin in the Regulation of Epithelial Tight Junctions
… constitute the primary component of epithelial barrier function, a disruption of which is involved in the pathogenesis of many gastrointestinal, pulmonary and renal diseases. Occludin is the major transmembrane protein of TJ, a deletion of which leads to a complex phenotype including chronic …
-
On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy
… and platelet recruitment as well as epithelial barrier dysfunction, are considered to constitute key components in the pathophysiology of radiation-induced enteropathy. The aim of this thesis was to investigate the basic mechanisms behind leukocyte-platelet-endothelial cell interactions in the …
-
Giardia Cathepsins and Their Role in Intestinal Disease
… of giardiasis includes intestinal barrier dysfunction and cytoskeletal injury; however, the mechanisms or parasitic factors involved remain unclear. The Giardia genome contains genes for cathepsin-like cysteine proteases; however, their roles are unknown. Using an in vitro model for …
-
INFLAMMATORY AND T-CELL HOMEOSTASIS PARAMETERS IN DUAL AND TRIPLE COMBINATION ANTIRETROVIRAL THERAPY (CART) FOR HIV INFECTION
… initiation; (2) assessing immune parameters, gut barrier dysfunction, and mitochondrial stress in PLWH switching from triple to dual INSTI-based cART; and (3) evaluating T-cell homeostasis and activation in virally suppressed individuals transitioning to the long-acting injectable regimen …
-
Hemodynamic regulation of blood-brain barrier phenotype: A cooperative effort linking adherens and tight junction complexes
… cells (BBMvEC’s) creating the blood-brain barrier (BBB), a critical regulator of CNS homeostasis. Junctional disassembly and barrier dysfunction are established features of cerebrovascular diseases (e.g. stroke) manifesting compromised blood flow, allowing us to hypothesize a pivotal …
-
Determinants of systemic treatment response in atopic dermatitis
… heterogeneous pathophysiology involves epidermal barrier dysfunction, immune dysregulation, and alterations of the skin microbiome. Despite major advances through targeted therapies, predictors of individual treatment response remain poorly defined. This thesis investigates systemic therapies for …
-
Microbiota-host interactions and infection dynamics in critical illness.
… infections, largely attributed to immune dysfunction and impaired host defense. We recently reported that intestinal dysbiosis in critically ill patients is associated with expansion of hypofunctional immature neutrophils, resulting in a significant reduction in infection-free survival. To …
-
Computational Modeling of Claudin-15 Paracellular Channels
… curvature and branching while maintaining barrier integrity. A validated reduced pore model enabled extensive simulations across ionic conditions and voltages, establishing that octameric pores form via overlapping tetramers. Residue D55 functions as the core electrostatic selectivity …
-
Host parasite interaction in a mouse model of inflammatory bowel disease
… tocolonic inflammation? (3) Does gut epithelial barrier dysfunction play a role in translocationof bacteria and the development of colitis? Our results reveal that mdrla KO mice have amore Th 1 type of gut environment and delayed worm expulsion compared to the wild type. Inaddition, we found that …
-
Propranolol Elicits Long Term Systemic Effects After Repetitive Mild Traumatic Brain Injury
… the brain after mTBI as a result of blood brain barrier dysfunction, sympathetic nervous signaling, and the release of inflammatory mediators. Recent studies have shown sympathetic activation after injury can result in IL-10 dependent systemic immunosuppressive state after mTBI. In this study we …
-
Development of Novel Methods to Study Host-Microbe Interactions In The Larval Zebrafish Gastrointestinal Tract
… <p>The intestinal epithelium, a critical barrier against pathogens, toxins, and other environmental stressors, undergoes rapid turnover. Extrusion, the process by which excess or compromised cells are shed from epithelial layers, is vital to maintaining barrier integrity. Despite extensive …
-
RAC1-Mediated Actin Cytoskeleton Remodeling and Monolayer Barrier Properties of Stretched Alveolar Epithelial Cells
… due to basement membrane deformation and reduced barrier function. AECs maintain integrity of the blood-gas barrier with gasket like intercellular tight junctions (TJ) which are anchored internally to the actin cytoskeleton. Our goal was to evaluate the effect of physiologically relevant, high …
-
Role of Slit2 in Reducing Complications after Surgical Brain Injury
… in post-operative complications. Blood brain barrier (BBB) disruption and neuroinflammation are major pathophysiological consequences after neurosurgical injury. Blood brain barrier dysfunction leads to increased influx of water and plasma proteins as well as peripheral immune cell …
-
Investigating role of IL-4 receptor alpha (IL-4Ra) in murine models of atopic dermatitis
… and genetic predisposition factors. Primary skin barrier dysfunction and aberrant T helper 2 (TH2) responses to common allergens, together with increased serum IgE antibodies, characterise the disease. B and T cells are essential in the disease manifestation, however, the exact mechanism of how …
-
Effect of Diabetes Mellitus on Ocular Surface Tight Junctions and Glycocalyx
… include impairment of corneal epithelial barrier function, conjunctival defects, increased incidence of corneal and conjunctival infections and higher prevalence of dry eye disease. Impairment of tight junctions and glycocalyx, which are critical for ocular surface barrier function, may …
-
Follow your gut: Does AKR1D1 impact gastrointestinal health?
Dysfunction of the gut-liver axis contributes to non-alcoholic fatty liver disease (NAFLD) pathogenesis and progression. Bile acid homeostasis is disrupted in NAFLD, and this has been suggested to increase cytotoxic bile acids species in the intestine, disrupt cytoprotective intestinal bile acid …
Page 1 of 2