Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Barrett's"”.
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Clonal Dynamics in Barrett's Oesophagus and Oesophageal Adenocarcinoma
… stage. OAC has a metaplastic pre-cursor lesion, Barrett’s oesophagus (BO), which can be monitored and effectively treated if dysplasia develops. Screening for BO could improve outcomes but needs to be balanced with the consequences of over-diagnosis and over-treatment since most BO will not …
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Biomarkers of Progression from Barrett's Oesophagus to Oesophageal Adenocarcinoma
Barrett’s oesophagus (BO) is a pre-malignant condition for oesophageal adenocarcinoma (OAC) [1], the incidence rate of which has been rising dramatically over the last four decades in the western world [2, 3]. Survival of an OAC affliction is poor, and one of the ways to improve this would be by …
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Development of a real time trimodal spectroscopy diagnostic tool for Barrett's esophagus
Barrett's esophagus (BE) is a condition of the lower esophagus caused by gastroesophageal reflux disease. Patients with BE have an increased probability of developing dysplasia, an abnormal growth or development of cells. This dysplasia in BE is a precursor to cancer of the esophagus, but is …
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A Study to Investigate Factors Involved in the Development of Oesophageal Carcinoma
… true for patients with the precursor lesion, Barrett's oesophagus. The current study considered the hypothesis that patients with Barrett's oesophagus were deficient in antioxidants compared to reflux patients without evidence of Barrett's oesophagus.<br/><br/>Bcl-2 is an inhibitor of …
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Clinicopathological and molecular characterization of gastroesophageal junction (GEJ) adenocarcinoma before age of 40 years
… and columnar epithelium, intestinal metaplasia (Barrett's mucosa), glandular dysplasia, and adenocarcinoma. Comparisons were performed by the X2 test, Fisher's exact test, Student's t-test and Mann-Whitney U-test as appropriate. Survival was estimated by the Kaplan-Meier method with univariate …
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Identification of Two Novel Genome-Wide Significant Single Nucleotide Polymorphisms, associated with Barrett’s Oesophagus, determined by further Replication of a Genome-Wide Association Study
Barrett's oesophagus (BE) is a common premalignant condition to oesophageal adenocarcinoma (EAC). A previous genome-wide association study (GWAS) identified BE susceptibility Single Nucleotide Polymorphisms (SNPs) on chromosome 6p21, within the HLA region, and16q23, where the closest protein-coding …
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Merging 20th Century Art Music and Pre-recorded Sound: 17 Pieces
… (d.1990), Iannis Xenakis (d.2001) and Natasha Barrett (1972-). This was a practice-based PhD resulting in the creation of a series of new compositions for a variety of forces that addressed the following research questions: 1. What have been the problematics of the development of compositions …
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The involvement of bacteria in the progression of Barrett’s oesophagus to adenocarcinoma of the oesophagus
Barrett's oesophagus (BO) arises from chronic gastro-oesophageal reflux disease(GORD). Patients have an increased risk of adenocarcinoma (ADC), which is the sixth most common cause of cancer mortality in the UK. All ADC develop from BO, and over the last twenty years there has been a marked …
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Advances in the endoscopic management of esophageal neoplasia using ultrahigh speed endoscopic optical coherence tomography
… with a five-year survival rate of only 16.7%. Barrett's esophagus (BE) is a premalignant condition with increased risk of developing into esophageal adenocarcinoma, the most common type of esophageal cancer in the West. In current BE surveillance protocol, random biopsies are used to diagnose …
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High resolution imaging of neoplasma using optical coherence tomography
… on tamoxifen, with gastro-esophageal reflux or Barrett's and also guidance of surgical procedures in sensitive areas. Further improvements of the OCT technology will most likely enhance the abilities of the technique and may eventually lead to its establishment as a a powerful imaging modality …
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Diagnostic and therapeutic devices and applications of endoscopic optical coherence tomography
… (GI) tact diseases were investigated: Barrett's esophagus (BE) and associated dysplasia, and chronic radiation proctopathy (CRP). For the second project, esophageal electrical muscle stimulation methods were assessed to achieve circumferential esophageal tissue coverage for catheter …
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Klinische Charakteristika und Verlauf einer Patientengruppe mit Barrettösophagus
Untersuchung eines Patientenkollektives mit Barrettösophagus und Follow-up Studie einer APC Studie; Erfassung des Symptomverlaufes vor und nach Therapie und Rezidive.
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Deep Learning in Oesophageal Cancer Development: Integrating Multi-Stain Histopathology Images of the Capsule Sponge
Barrett’s oesophagus (BE) is a premalignant condition that increases the risk of oesophageal adenocarcinoma (OAC). Surveillance relies on endoscopy with random biopsies, a costly and invasive procedure that limits population-scale feasibility. The capsule sponge, a pan- oesophageal cell collection …
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Characterisation of Copy Number Changes in the Progression of Barrett’s Oesophagus
… the development of oesophageal adenocarcinoma is Barrett’s oesophagus (BE). To diagnose those patients who will progress to cancer early to improve the dismal survival rate of oesophageal adenocarcinoma, patients with BE undergo regular endoscopic surveillance. The vast majority of patients, …
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The Use of 2D and 3D Models to Study Competition in the Context of Barrett’s Oesophagus and Oesophageal Adenocarcinoma
… through an identifiable pre-cursor stage, Barrett’s Oesophagus (BO). BO can progress via the accumulation of further genetic and morphological changes into low-grade and then high-grade dysplasia. This development process is believed to take place over many years or decades and offers …
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Integrating Epidemiological and Genomic Factors to Inform Outcomes in Barrett’s Oesophagus and Oesophageal Adenocarcinoma
… increased, and its prognosis remains poor. Barrett’s oesophagus (BO) is considered the precursor to OAC, however, BO is not apparent adjacent to tumour in nearly half of OAC patients. We have previously demonstrated that patients with BO-adjacent tumours (BO+ve OAC phenotype) have a …
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Multi-omic characterisation of Barrett’s oesophagus reveals a molecular continuum in the progression to oesophageal adenocarcinoma
Barrett’s oesophagus (BE) is the main risk factor for the development of oesophageal adenocarcinoma (OAC) yet only 0.4%/year of non-dysplastic (ND) BE cases progress to cancer (Bhat et al., 2011). In this thesis I present the first comprehensive, multi-omics study comparing indolent, …
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Driver genes, mutational signatures and the timing of mutations in oesophageal adenocarcinoma
… of oesophageal adenocarcinoma (OAC) from Barrett’s oesophagus provides an excellent model of the step-wise progression of malignancy. This process is strongly associated with the reflux of stomach contents into the oesophagus. However the exact mechanism by which low pH and bile acids …
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Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy
… endoscopes for detection of dysplasia in Barrett’s oesophagus. To enable molecular imaging with a newly discovered targeted fluorescent contrast agent, a bimodal endoscope capable of capturing NIR fluorescence and white light reflectance was developed around a clinically translatable …
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