Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Barnes maze"”.
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Endocannabinoid Modulation of Spatial Memory in Aversively and Appetitively Motivated Barnes Maze Tasks
… (i.e., conditioned fear and Morris water maze) paradigms, but not in operant procedures in which food reinforcement is earned. It is difficult to discern whether the differential effects caused by CB1 receptor disruption on extinction result from the hedonics (i.e., aversive vs. …
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Age sensitivity of the Barnes Maze and the Morris Water Maze: Associations with cerebellar cortical Purkinje neurons
… substrates as assessed by the Morris water maze (MWM) and the Barnes maze. The MWM is one of the most widely used tests of spatial memory and numerous studies suggest that spatial memory abilities decline with age. To contrast, very few studies exist comparing different ages of mice in the …
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EGCG and voluntary exercise : an examination of treatment effects using the TgCRND8 mouse model of Alzheimer's disease
… measures: learning and memory performance in the Barnes maze, nest building, the open-field, anxiety in the light-dark box, and 2) soluble, amyloid-beta levels in the cortex and hippocampus. Untreated Tg mice showed deficits in nest building behaviors, as well as poor spatial learning in the …
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Targeting Kremen1 Downregulation with RVG-9R/siRNA Complexes in the Triple-Transgenic Mouse Model of Alzheimer’s Disease
… and half female. Following the injections, the Barnes Maze was administered to each mouse in order to assess memory function. Data gathered from the Barnes Maze shows 3xTg-AD mice have a longer primary latency in the probe phase compared to WT mice. Of mice tested, fewer 3xTg-AD mice have been …
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Single and Combined Effects of Cannabinoids on Neuropathic Pain and Cognition
… Discrimination with a reversal component, and 3) Barnes Maze. Results. Cannabidiol was found to be more potent and more effective than -9-THC in attenuating neuropathic pain in a dose dependent manner. Combinations of CBD+-9-THC revealed that lower, ineffective doses of CBD and -9-THC display …
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A streptozotocin-induced model of Alzheimer's disease in mice with wild-type human tau
… in transgenic mice expressing human tau. The Barnes maze, a test of spatial learning and memory, and a panel of antibodies directed at biochemical changes in tau associated with AD were used to assess memory deficits and tau pathology, respectively. The behavioral and biochemical findings of …
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Effects of Proton Radiation on Behavior in a Mouse Model of Alzheimer’s Disease
… hippocampal damage, was assessed using the water maze and Barnes maze 3 and 6 months after irradiation. Transgenic mice performed worse than wild-type mice on both behavioral measures, and wild-type mice exposed to 0.5 Gy performed worse than the 0 Gy wild-type mice at 6 months post-irradiation. …
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Evaluation of Seizure Threshold as an Early Behavioral Marker of Disease Progression in the Mouse Model of Mucopolysaccharidosis IIIA
… for learning and memory impairments using the Barnes maze and novel object recognition behavioral assays did not show a neurological defect earlier than 20 weeks. These results suggest an intact cognitive capacity for the diseased animals. To test whether seizure threshold is altered in …
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Identification and validation of target pathways influencing outcome after traumatic brain injury
… I testing paradigms (Rotarod, Morris Water Maze, and Barnes Maze), we characterized spatial memory and motor function deficits resulting from TBI in order to quantify a "good" or "poor" response. Using a variety of targeted intervention strategies (CD40L knockout, administration of …
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The effects of parental experience on cognition, anxiety-like behaviour, and hippocampal plasticity in a biparental species.
… more anxiolytic behaviour on the elevated plus maze. Furthermore, biparental males exhibited impaired spatial learning, while monoparental females exhibited enhanced spatial learning on the Barnes maze. In the hippocampus, parental experience did not affect the density of microglia and the …
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Breakfast dietary protein sources affect satiety and cognitive performance
… by protein source. In another cohort of rats, Barnes maze was used to test spatial learning and memory following the same BF protocol. Rats that were not provided breakfast moved slower and displayed compromised working and long-term memory. Rats fed higher dietary protein BF were more active …
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Role Of The α1A-Adrenergic Receptor In Synaptic Plasticity, Cognition & Neurogenesis
… agonist cirazoline (CRZ) were tested on the Barnes maze. CAM α1A-AR and CRZ-treated mice performed better and α1A-AR KO mice performed poorer than WT. Long-term potentiation (LTP) experiments on aged CAM α1A-AR mice revealed enhanced LTP in CAM α1A-AR mice versus WT. Therefore, we …
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Retinoid X Receptor as a Mediator of Post Stroke Recovery by Reversing Age-Associated Phenotypes of Microglia/Macrophages
… days 3, 7, 14, and 28) and cognitive function (Y maze, Barnes maze, and novel object recognition test on day 30) were evaluated. We found that BEX significantly improved sensorimotor and cognitive functions in RXRa<em><sup>fl/fl</sup></em> mice. The beneficial effect of BEX on neurological …
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EXERCISE-INDUCED ORGAN PROTECTION IN A MURINE MODEL OF CARDIAC ARREST AND RESUSCITATION
Cardiac arrest causes whole-body ischemic injury and cell death. Successful cardiopulmonary resuscitation paradoxically confounds recovery by increasing the rate of cellular death and tissue damage through global reperfusion injury. Despite decades of basic and clinical research, the prognosis …