Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Barbiturates"”.
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The Design and Synthesis of Novel Barbiturates of Pharmaceutical Interest
… as immune modulators. The recent explorations of barbiturates and their potential anti-cancer and immune modulating properties are the subject of this work. Novel synthetic approaches to the development of new barbituric acid derivatives were explored thoroughly, and the mechanisms of these novel …
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The influence of glucose on the action of barbiturates in the mouse
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The role of the cholinergic system in the anticonvulsant effects of the barbiturates and other anticonvulsants
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Synthesis and Antifungal Evaluation of Barbiturate Saponins And Progress Towards Cysteinyl Metal Peptides
… their biological activities would be described. Barbiturates and steroidal saponins have shown remarkable antifungal activity in the biological assays. Therefore, attempts were directed to combine the barbiturate with the steroid to give novel antifungal agents. The need for extensive SAR studies …
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Towards interlocked structures based on H-bonded barbiturate complexes
… the importance of the macrocycle size. Barbiturates disubstituted with flexible chains terminated either by reacting groups (anthracenes, olefins) or stoppers (trityl) were also synthesised. The fluorescence properties of anthracene-tagged barbiturates and their kinetics of …
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The Use of ThorazineR (Chlorpromazine Hydrochloride) as an Aid to Analgesia and Amnesia During Labor and Delivery
… DemerolR, scopolomine, paraldehyde, and the barbiturates, have been employed alone or in combination. Because of the depressant properties of these drugs, they cannot be used without due consideration of these effects. Thus the search continues for more efficient agents to relieve the pains …
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Intracellular distribution of pentobarbital sodium in rat brain
"The major effect of the barbiturates is depression of the central nervous system, but the way in which these drugs exert their effect is not yet well understood...As the biochemical functions of the cell and its various parts become better understood, it is of interest to relate the actions of t a …
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Adolescent Involvement in Alcohol and Drug Use
… alcohol, tobacco, cannabis, amphetamines, barbiturates, cocaine, the opiates and also the hundreds of medicines to be found in chemist shops. Our society is a drug taking society, that is a pill for every ill. There are drugs for sleeping, headaches, stomach ailments, almost everything …
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The crystal and molecular structures of some transition metal-barbiturate complexes
… substrates to form aggregate molecules. The barbiturates on the other hand are members of a group of widely used drugs known as hypnotics, many of which are medicinally applied today.
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Paper spray mass spectrometry (PS-MS) for toxicological drug screens and biomonitoring of chemical warfare agent exposure
… is demonstrated for both a simple screen of barbiturates and other acidic drugs (Chapter 2) and the detection and quantitation of chemical warfare agent hydrolysis products (Chapter 3). Additionally, a positive ion drug screen is applied to the analysis of postmortem blood samples (Chapter …
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New hydrogen bonding motifs for anion and neutral guest complexation
… of a simple benzimidazole cleft receptor for barbiturates and ureas are reported. Compared to various control analogues, the receptor binds barbital or urea in highly competitive DMSO/MeNO2 solutions. A crystal structure with barbital revealed binding through six hydrogen bonds. The synthesis …
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Novel Building Blocks for Molecular Imprinting: Pyridine-Based Binding Monomers and Bio-Renewable Cross-Linkers
… interest such as biotin and barbiturates using a series of pyridine-based binding monomers which contain hydrogen bonding arrays complementary to their particular targets. MIPs are already widely used for the creation of artificial receptors that will be less expensive, more …
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Papain: a Novel Urine Adulterant.
… of other frequently abused drugs: amphetamines, barbiturates, benzodiazepines, cocaine, opiates, and phencyclidine, along with gas chromatography/mass spectrometry (GC/MS) of THC-COOH and high pressure liquid chromatography/ultraviolet detection (HPLC/UV) of nordiazepam was performed in order to …
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The effects of anaesthetic agents on synapses of lymnaea stagnalis (L.)
… studies, that injection and bath perfusion of barbiturates does not lead to responses in Lymnaea comparable to that of the mammal. In addition to it's main target site, ketamine (a frequently used intravenous anaesthetic) has also been shown to act at cholinergic receptors. The effects of …
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An evaluation of analytical procedures for detection of drug abuse with particular reference to opiates.
… drug screening programme for amphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine and opiates involving some 1400 subjects by enzyme immunoassay, carried out by the author, are reported. The corresponding confirmatory tests by GC-MS on samples screening positive by immunoassay …
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Effects of some analeptic drugs against deep pentobarbital anesthesia in dogs
Thesis (M.S.)--Michigan State University. Dept. of Pharmacology, 1965
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The role of the periaqueductal gray in modulation of acute and chronic pain: Actions of drugs with analgesic properties on periaqueductal gray neuronal network
… responses. These results suggest that the use of barbiturates to study PAG neuronal responses might have resulted in significant un-intended modifications of the fundamental properties of PAG neuron, as compared to the unanesthetized state. The PAG is important part of pain modulatory network, but …
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Endogenous neurosteroid actions at GABAA receptors during neuronal development
… useful compounds including benzodiazepines, barbiturates and certain general anaesthetics. In addition, several naturally occurring steroids typified by the progesterone metabolite 5a-pregnan-3a-ol-20-one (5a3a) are potent positive allosteric modulators of GABAAR function - a property that …