Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Barbiturate"”.
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Barbiturate treatment in experimental transient focal cerebral ischaemia
… had not been specifically investigated with barbiturate treatment. Cerebral infarction is progressive and evolves over hours, proceeding from ischaemia and functional loss to cell death. Sundt et al (1969), Crowell et al (1970), Hayakawa and Waltz (1975). Complete recovery is possible if …
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Towards interlocked structures based on H-bonded barbiturate complexes
Despite the privileged position of Hamilton’s barbiturate binding system in supramolecular chemistry, this motif has never been used in generating interlocked structures, such as rotaxanes or catenanes. This thesis demonstrates the feasibility of such structures. A series of Hamilton-like receptors …
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The crystal and molecular structures of some transition metal-barbiturate complexes
… in the clinical detection and identification of barbiturate drugs and this aspect is discussed in a later section. An infrared study of these compounds is also described. The individual components of the complexes, viz. the transition metals and the barbiturate ligands are in themselves of great …
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Synthesis and Antifungal Evaluation of Barbiturate Saponins And Progress Towards Cysteinyl Metal Peptides
… dissertation, methods for preparation of novel barbiturate saponin as antifungals and their biological activities would be described. Barbiturates and steroidal saponins have shown remarkable antifungal activity in the biological assays. Therefore, attempts were directed to combine the …
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Hemmung des nukleären Transkriptionsfaktors aktivierter T-Lymphozyten (NFAT) durch Barbiturate : Mechanismus und Wirkung
Barbiturate werden bei der Therapie eines erhöhten intrakraniellen Druckes auf der Intensivstation bei Patienten mit schwerem Schädelhirntrauma eingesetzt. Eine kontinuierliche, langandauernde und hochdosierte Barbiturattherapie mit Thiopental erhöht in klinischen Studien jedoch die Inzidenz …
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The impact of barbiturate therapy in children with severe traumatic brain injury (TBI)
… Specifically, evidence is limited on the use of barbiturate therapy as a second-tier treatment option for uncontrolled ICP in children, in part because cohort sizes are small and there are little data on physiological effects. To address this, we evaluated the impact of thiopentone on …
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Intracellular distribution of pentobarbital sodium in rat brain
"The major effect of the barbiturates is depression of the central nervous system, but the way in which these drugs exert their effect is not yet well understood...As the biochemical functions of the cell and its various parts become better understood, it is of interest to relate the actions of t a …
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Process of Care and Outcome of Critically Ill Patients with Traumatic Brain Injury
… I evaluated whether decompressive craniectomy or barbiturate coma provides better value, in terms of health effects and costs, for the management of refractory intracranial hypertension following TBI. Decompressive craniectomy resulted in greater quality-adjusted life expectancy relative to …
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Preparation and properties of N-pentafluorosulfanylamido derivatives
… chloride, fluoride, and sulfide to form a barbiturate were unsuccessful. N-Phenyl-N’-pentafluorosulfanyl was prepared from pentafluorosulfanyl isocyanate and aniline. Attempts to prepare the mixed urea from pentafluorosulfanylamine and phenyl isocyanate failed. A possible product from a …
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Influence of dietary Mirex and nutritive restriction on cottontail rabbit reproductive physiology
… enzyme activity as evidenced by shorter barbiturate-induced sleeping times and greater liver weights. Nutritional restriction reduced body, carcass, kidney, and ovarian weights, femur bone marrow fat, and the proportion of rabbits which ovulated or conceived, but did not significantly …
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Intravenous anaesthetics inhibit nicotinic receptor-induced membrane currents and Ca 2+ -transients in rat intracardiac neurons
… receptor (RyR) channels is unlikely. The barbiturate pentobarbital and the dissociative anaesthetic ketamine used at clinical EC50 concentrations were also shown to inhibit nAChR-induced increases in [Ca2+]i. In conclusion, thiopental and other i.v. anaesthetics may inhibit nAChR-induced …
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Biotransformation von N-Alkyl- und N,N-Dialkylarylaminen durch Bacillus megaterium
… Hierbei wurde gezeigt, dass durch bestimmte Barbiturate die arylische Hydroxylierung als auch die N Deethylierung gesteigert wurden. Repression der Hydroxylierungs- und N Dealkylierungsaktivität zeigte sich durch Metyrapon, n-Octylamin, Pyridin und Imidazol. Die von Bacillus megaterium …
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The effects of anaesthetic agents on synapses of lymnaea stagnalis (L.)
… anaesthetic response of the animal model to this barbiturate. The presence of gamma-aminobutyric acid (GABA) receptors has been demonstrated in a respiratory interneuron (RPeD1) both electrophysiologically and via molecular techniques, however inmiunostaining has proved negative in RPeD1 and …
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Regulation of Luteinizing Hormone and Catecholamine Release
… with Prog., rats received either saline, the barbiturate, phenobarbital, the GABAg agonist, baclofen, the GABA^ agonist, muscimol, or either the GABA^ antagonist, bicuculline, or the putative GABAg antagonist, 5-aminovalerate. Additional experiments tested the effects of the GABA drugs on LH …
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Corticotomy enhanced orthodontics.
… Euthanasia Injection (60mg/mL with 1mL/Kg of a barbiturate derivative made by Virbac (Australia)). Following this period, the rat maxillae was dissected out and prepared for resin embedding and micro- CT scanning. Micro-CT scanning was performed in a Skyscan 1174 at the Institute of Medical and …
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Mechanism of anaesthetic activation, combination and antagonism
The type A γ-aminobutyric acid receptors (GABAAR) – pentameric ligand gated ion channels (pLGICs) – are the main mediators of fast inhibitory neurotransmission in the human brain. Malfunctions in these receptors are a common cause for neurological disorders such as anxiety, epilepsy, schizophrenia …