Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Bacterial virulence"”.
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The regulation of bacterial virulence by mucin glycans
… of potentially pathogenic microbes. The virulence-disruption activity of mucus is enabled mucin, a glycoprotein that forms the mucus gel. Upon sensing the O-glycans displayed mucin, opportunistic pathogens can alter their gene expression, and are less likely to engage in virulence …
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Analysis of Small Molecule Inhibitors Aimed at Bacterial Virulence
<p>The emergence of antibiotic-resistant bacterial pathogens and the discovery of new bacterial pathogens have motivated the development of novel antibacterials. One recently proposed strategy is to target pathogenic bacteria specifically by inhibiting virulence mechanisms as opposed to killing …
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Disentangling bacterial virulence mechanisms: Klebsiella pneumoniae targets post-translational modifications (PTMs) to manipulate innate immunity
… ISG15 and its associated PTM in the context of bacterial infection remains poorly understood. <br/><br/>Using an in vitro infection model, I show that K. pneumoniae targets ISGylation and additional host PTMs to attenuate the innate immune response to infection. These results uncovered that …
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The Molecular Characterization of Phosphorylcholine (ChoP) on Histophilus somni Lipooligosaccharide: Contribution of ChoP to Bacterial Virulence and Pathogenesis
Histophilus somni virulence factors include expression and antigenic variation of lipooligosaccharide (LOS). Phosphorylcholine (ChoP) is often expressed on H. somni LOS and also undergoes antigenic variation. In this study, five genes that play a role in expression and antigenic variation of ChoP, …
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Evidence of Water to Human Transmission of Aeromonas Hydrophila: Critical Role of Quorum Sensing in Bacterial Virulence & Host Response
… bacterium which produces a wide variety of virulence factors leading to both intestinal and extra-intestinal infections in humans. A large number of water and clinical Aeromonas isolates were molecularly finger-printed and our data provided the evidence of successful colonization and …
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Regulation of amylovoran biosynthesis in Erwinia amylovora
… amylovora, is one of the most devastating bacterial diseases for the apple and pear industry. Two pathogenicity factors strictly required for E. amylovora to cause disease are the exopolysaccharide amylovoran and the type III secretion system. In bacteria, the two-component signal …
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Identification of bacterial pathogenic gene classes subject to diversifying selection
Availability of genome sequences for numerous bacterial species comprising of different bacterial strains allows elucidation of species and strain specific adaptations that facilitate their survival in widely fluctuating micro-environments and enhance their pathogenic potential. Different bacterial …
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Novel Virulence Factors in the Pathogenesis of Yersinia pestis Infection, the Causative Agent of Plague
Identification of new virulence factors in Yersinia pestis, the causative agent of plague, and understanding their molecular mechanisms during an infection process are necessary in designing a better vaccine or to formulate an appropriate therapeutic intervention. By using a high-throughput, …
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Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis
Mycobacterium tuberculosis is a bacterial pathogen that causes tuberculosis, a leading cause of human death worldwide from infectious diseases, especially in Africa. Despite enormous advances achieved in recent years in controlling the disease, tuberculosis remains a public health challenge. The …
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Examination of Molecular Recognition in Protein-Ligand Interactions
… drug-like inhibitors of a prototype of bacterial two-component signal transduction response regulator using computational and experimental methods. The second project was the development and validation of a scoring function, PHOENIX, derived using high-resolution structures and …
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Cloning and characterization of neuraminidase from Salmonella typhimurium LT-2 and its relationship to neuraminidase from other bacteria
Bacterial neuraminidases (NANases) have been proposed to be bacterial virulence factors because of their ability to cleave sialic acid residues from host glycoconjugates. The gene encoding NANase (nanH) from Salmonella typhimurium has been cloned and its protein product purified. The purified …
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Investigating Hfq-dependent Small Regulatory RNA, Bsr34, and Its Roles in Brucella abortus Physiology and Pathogenicity
… Hfq, are key post-transcriptional regulators of bacterial virulence and stress adaptation, yet remain largely uncharacterized in Brucella. Following the identification of Hfq-associated sRNA candidates in B. suis, this study provides the first functional characterization of Bsr34, an …
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Small molecule inhibitors against enteric bacterial glycosyltransferases
Enteric bacterial pathogens are the major sources of foodborne diseases. Infection caused by these pathogens leads to gastroenteritis thus of great threat to public health. Pathogenic bacteria evolved to develop various secretion systems to deliver virulence proteins termed ‘effectors’. These …
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Molecular Basis of Corynebacterium Diphtheriae Virulence and Infection In The Caenorhabditis Elegans Model Host
… is certainly caused by diphtheria toxin, corynebacterial colonization may primarily require proteinaceous fibers called pili, which mediate adherence to specific tissues. The type strain of C. diphtheriae possesses three distinct pilus structures, namely the SpaA, SpaD, and SpaH-type pili, which …
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Chemical Reporters for Investigating Lipidated Proteins at the Host-Pathogen Interface
… to neurological disorders. Moreover, viral and bacterial pathogens can exploit and modulate the host lipidation machinery to enhance infection. Robust biochemical methods for characterizing lipidated proteins are therefore important for understanding fundamental physiology and disease …
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Glycans in host-pathogen interactions : an integrated biochemical investigation
… involves a study of the effect of secreted bacterial sphingomyelinases on the epithelial cell surface proteoglycan (a large glycan- protein conjugate), syndecan-1 and on epithelial tight junctions. The findings presented in this work suggest mechanisms by which sphingomyelinases could …
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Curli Production and ERIC-PCR Fingerprinting of Escherichia coli from Clinical Cases of Bovine Mastitis
… thought to be more related to cow factors than bacterial virulence. Some strains of E. coli, however, may be adapted to colonizing mammary tissue, increasing clinical severity, and impairing recovery. Curli are adhesive surface structures produced by some E. coli and Salmonella strains that bind …
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Novel antibiotics from DNA adenine methyltransferase inhibitors
… adenine methylation plays a role in several core bacterial processes, including DNA mismatch repair, the timing of DNA replication and gene expression. The dependence of bacterial virulence on the activity of Dam, an adenine methyltransferase, makes it an attractive target for novel antibiotics. …
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The Characterization of PG0228 in Porphyromonas gingivalis W83
… non-coding RNAs (sRNAs) have been related to bacterial virulence. Many of these sRNAs require the facilitation of the bacterial Sm-like protein, Hfq, for optimum function. Hfq is a RNA chaperone involved in RNA stability, sRNA function, and polyadenylation. Mutants lacking in Hfq often show …
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"A syndrome so characteristic" Molecular and clinical studies of Fusobacterium necrophorum and Lemierre's syndrome
… first studies underlying this thesis focused on bacterial interaction with coagulation. The contact system initiates the intrinsic pathway of coagulation and the release of the pro-inflammatory peptide bradykinin. We found that the contact system was activated at the surface of F. necrophorum, …
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