Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Bacterial physiology"”.
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Post-translational modification of proteins secreted by Pseudomonas aeruginosa and its role in bacterial physiology
Pseudomonas aeruginosa is a multi-drug resistant, opportunistic pathogen capable of causing serious and potentially life-threatening infections worldwide. An important component of its infection strategy is the secretion of an extensive arsenal of virulence factors. These virulence factors cause …
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Illuminating the function of a master regulator of Caulobacter crescentus gene expression
… establish GcrA as an integral regulator of bacterial physiology and development.
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Free methionine sulfoxide reductase and its contributions to environmental stress response in Komagataeibacter hansenii
… The ΔmsrC mutation greatly affects growth, bacterial cellulose synthesis, abscisic acid response, quorum sensing and variability of cell size. Complementation restored some WT characteristics but revealed new phenotypes linked to bacterial cellulose synthesis. The tolerance to reactive …
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Exploring and enhancing context-dependent beta-lactam antibiotic efficacy
… are essential medical tools for the treatment of bacterial infections. Unfortunately, clinical treatment efficacy is declining over time as bacteria adapt to and evade antibiotic treatment through mechanisms called antibiotic resistance, tolerance, and persistence. Antibiotic tolerance and …
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Rapid nutrient fluctuations and their implications for bacterial growth
… for growth, and the tight coupling between bacterial growth physiology and nutrient availability has long been observed. When nutrient environments shift on timescales of hours, days or seasons, bacteria adapt to a physiological steady state characteristic of the new environment. However, …
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Acinetobacter baumannii toksino-antitoksino sistemos CheTA antitoksino veikimo mechanizmo paieška /
… remain elusive. In the last two decades bacterial toxin-antitoxin (TA) systems, genetic loci abundant in low copy number plasmids and chromosomes, sparked a great interest from scientists. They have been proposed to fulfill a myriad of roles in bacterial physiology, including plasmid …
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Investigating The Single Cell Heterogeneity and Physiological Impact of Mistranslation
<p>Bacterial populations grow clonal populations; however, individual cells have a variety of phenotypes. The physiological heterogeneity observed in populations has been attributed to variations in the processes of gene expression. For example, promoter expression has been shown to be …
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Regulatory RNAs at the Heart of Sugar Metabolism: New Mechanisms and Novel Discoveries
… important insights into the different aspects of bacterial physiology, including RNA decay pathways, transcription of long operons and cellular differentiation. We argue that posttranscriptional regulation is of greater importance to Bacillus subtilis (and probably all bacteria) than previously …
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The effects of low-shear modeled microgravity on Streptococcus pneumoniae and adherent-invasive Escherichia coli
… and on adherent-invasive Escherichia coli (AIEC) physiology and colonization properties. Habitation in space exposes both humans and microbes to microgravity conditions which are characterized by reductions in fluid shear forces. Areas of low-shear stress are also encountered in physiologically …
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Controlling Pseudomonas aeruginosa Persister Cells by Human Granulocyte Macrophage Colony-Stimulating Factor
… antibiotic treatments are discontinued. During bacterial invasions, the host immune cells secrete special signaling proteins, known as cytokines which orchestrate events leading to human immune response and elimination of bacterial pathogens. However, compared to the well documented …
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Insights Into The Reactivation, Regulation and Essentiality of Oxidative Protein Folding Pathways In Actinobacteria
… pathways influence processes essential for bacterial physiology and pathogenicity. In the Gram-positive actinobacterial pathogens <em>Actinomyces oris </em>and <em>Corynebacterium diphtheriae</em> oxidative protein folding is catalyzed by the primary thiol-disulfide oxidoreductase MdbA. MdbA …
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Genome-Scale Quantification of Target Vulnerability in Mycobacterium Tuberculosis
<p>Essential bacterial genes orchestrate core biological processes and represent the targets of nearly all antibacterial drugs. Traditional genetic approaches such as knockout studies and transposon mutagenesis have cataloged hundreds of essential bacterial genes but provide no basis on which to …
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Outer Membrane Vesicle Production in Escherichia coli Relieves Envelope Stress and is Modulated by Changes in Peptidoglycan
<p>Bacterial outer membrane vesicles (OMVs) are spherical buds of the outer membrane (OM) containing periplasmic lumenal components. OMVs have been demonstrated to play a critical part in the transmission of virulence factors, immunologically active compounds, and bacterial survival, however …
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Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
… biomolecules required for maintaining bacterial physiology, where nucleotides with high energy are rapidly assimilated by UDP-linked intermediates. Additionally, the accumulation of energy-rich nucleotides coincided with the decline in cell growth rates, suggesting a concomitant …
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Integrated modeling of bacterial metabolism
… to achieve a system-level understanding of bacterial metabolism. Despite previous models have yielded insightful results, most of them focus on specific subsystems and endeavors to build highly integrated computational models are still rare. Here, I present my work towards developing and …
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Mycobacterium tuberculosis metallomics
… metal-based nanoparticles as potential antimycobacterial agents. Superparamagnetic iron oxide nanoparticles (SPIONs) were synthesised via co-precipitation of ferric chloride and ferric sulphate. The SPIONs were subsequently surface modified with secondary metals (Ag, Au, Cu, Ni) to generate …
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Elucidating mechanisms of toxicity and engineering Escherichia coli for tolerance of short chain fatty acids
… of short chain carboxylic acids during bacterial fermentation is described. This work offers new insights into carboxylic acid toxicity and methods for improvement of microbial tolerance that is important for improving productivity, titer, and yields for economical production of …
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Studies on the stress response in Fusobacterium nucleatum.
Fusobacterium nucleatum is a saccharolytic Gram-negative anaerobic organism belonging to the so-called ‘orange complex’ which is believed to play an important role in the microbial succession associated with the pathogenesis of periodontal disease. Its genome contains niche-specific genes shared …
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Carriage rate of staphylococcus aureusamong healthcare workers at the University Teaching Hospital in Lusaka
Staphylococcus aureus is a frequent cause of hospital-acquired infections worldwide. The carriage of S. aureus among healthcare workers has been associated with transmission of the bacterium to susceptible patients. The aim of this study was to determine the carriage rate, antimicrobial …
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Carriage rate of staphylococcus aureusamong healthcare workers at the University Teaching Hospital in Lusaka
Staphylococcus aureus is a frequent cause of hospital-acquired infections worldwide. The carriage of S. aureus among healthcare workers has been associated with transmission of the bacterium to susceptible patients. The aim of this study was to determine the carriage rate, antimicrobial …
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