Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Bacterial motility"”.
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Bacterial motility and growth in open and confined environments
… soil bacterium Pseudomonas putida (P. putida), a bacterial species that is able to form biofilms. We analyzed individual trajectories of swimming cells, both in the bulk fluid and in close proximity to a glass-liquid interface. Additionally, surface related growth during the early phase of biofilm …
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Exploring the optimality of various bacterial motility strategies : a stochastic hybrid systems approach
… determine where to swim. This chemotaxis allow bacterial populations to distribute themselves in accordance to distributions of nutrients found within an environment. We extend past work describing a chemotactic E. coli cell as an ergodic, stochastic hybrid system and use experimental data on …
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Molecular Analysis of Roseburia Cecicola, a Motile Anaerobe, as a Foundation for Study of Bacterial Motility and Chemotaxis in the Murine Gastrointestinal Ecosystem
… is being used as a model organism in the study. Motility may be essential for this organism to colonize its specific habitat in the mouse cecum. I purified the main protein (flagellin) of the flagellar apparatus of the organism. The purified protein was then used in raising polyclonal and …
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Natural and Synthetic Ligand-Binding Induce Different Pilin Assemblies in vitro and Control P. aeruginosa Bioactivities in vivo, and Development of Bacterial-Motility Enabled Binding Assays
<p>Proteins found on bacterial cells surfaces are capable of sensing and transducing signals from the environment to elicit a biological response. Fibrous appendages formed by assembly of pilin proteins on P. aeruginosa are surface proteins that are necessary for host colonization, adhesion on …
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Bacteria - Hydrogel Interactions: Mechanistic Insights via Microelastography and Deep Learning
… the limitations in treatment of solid tumors. Bacterial strains used for BBCT are engineered to express therapeutics, facilitate precise navigation within the tumor microenvironment by enhancing bacteria's motility, chemotaxis (movement toward or away from specific chemicals), or other …
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Image Analysis for Sliding Motility of <i>Clostridium perfringens</i>
The research investigates the sliding motility of Clostridium perfringens by employing machine learning-based image segmentation techniques and tracking to extract key quantitative characteristics of the movement of the bacteria. C. perfringens cells maintain end-to-end connections after cell …
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Regulation of flagellin glycosylation genes in Campylobacter jejuni: influence of NssR, the nitrosative stress response regulator.
… of undercooked, contaminated poultry. Motility, mediated by single polar flagella, is necessary for Campylobacter virulence. The flagellin proteins are extensively glycosylated in C. jejuni with pseudaminic acid and related derivatives; glycosylation is required for flagella filament …
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The Nature of Uropathogenic Escherichia coli ST127
… in the majority of ST127 isolates suggests that motility may be supressed in this lineage and the reason for the reported low prevalence of ST127. This report supports the long suspected, but never proved, notion that bacterial motility is one of the most important virulence traits relating to …
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Functional analysis of Shigella encoded IpaH E3 ubiquitin ligases in cell-autonomous immunity
… mechanisms; amongst them a family of twelve bacterial E3 ubiquitin ligases (IpaH) that are structurally unrelated to eukaryotic enzymes. IpaH ligases are injected into the host cytosol via the bacterial type III secretion system (T3SS) to manipulate the host cell and counteract anti-bacterial …
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A New Class of Antibiotic That Prevents Drug Tolerance, Persistence, and Resistance By Controlling Emergence of Phenotypes.
<p>The fight against bacterial infections and innovations in antibiotic therapy has never halted throughout human history. However, bacteria have evolved smartly and resistance against practically all conventional antibiotics has been developed. Furthermore, bacteria can form biofilms, which are …
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Evaluation of the antimicrobial activity of Plectranthus amboinicus leaf extracts on planktonic and biofilm forms of Staphylococcus aureus and Pseudomonas aeruginosa
… of S. aureus. The effect of the leaf extracts on bacterial virulence factors was also investigated. The extracts were shown to reduce alginate production, catalase activity, bacterial motility and induce the production of reactive oxygen species (ROS) and lipid peroxidation. Moreover, the leaf …
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Analysis of cellular responses to microwave irradiation in E. coli and change of oxygen level and culture medium in human cancer cell lines using RNA-seq based transcriptomic profiling
… membrane integrity and adhesion associated with bacterial motility. In comparison with other similar studies, our methodology allowed us to observe the impact of non-thermal effects of MWI at 2.45 GHz via simultaneous cooling. Our results in examining the transcriptomic profile of MCF7 and PC3 …
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Investigation of flagellotropic phage interactions with their motile host bacteria
Bacteriophages cohabit with their bacterial hosts and shape microbial communities. To initiate infection, phages use bacterial components as receptors to recognize and attach to hosts. Flagellotropic phages utilize bacterial flagella as receptors. Studies focused on uncovering mechanistic details …
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Modeling mechanical dynamics in chain-mediated bacterial sliding
Investigating the mechanical dynamics of bacterial motility has led to a deeper understanding of the behaviors and lifecycle of many bacterial species. We discuss chain driven sliding motility where the bacteria maintain connections between daughter cells following division, resulting in long …
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Molecular basis of NAIP/NLRC4 inflammasome activation by flagellin
… inner rod proteins (PrgJ). Recognition of these bacterial ligands by the NAIP receptors allows oligomerisation with NLRC4 and subsequent recruitment of caspase-1. Caspase-1 mediates pyroptosis, while recruitment of ASC is also required for cleavage of pro-IL-1β and pro-IL-18 to their active forms …
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PATTERNED BIOFILM FORMATION TO INVESTIGATE BACTERIA-SURFACE INTERACTIONS
<p>Bacterial adhesion to surfaces and subsequent formation of microcolonies play important roles in biofilm formation, which is a major cause of chronic infections and persistent biofouling. Despite the significance, mechanistic understanding of biofilm formation is still hindered by the structural …
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Physical and Deep-Learning-Based Explorations of Microbe-Mediated Reactive Transport Processes in Porous Media Across Scales
… Specifically, this work investigates microbial motility in porous microfluidic devices, a comparison of particle tracking methods in porous media, and an investigation of biomass growth and chromium reduction in the hyporheic zone. Furthermore, this dissertation details the development and …
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Towards Understanding the Genetic Basis of Virulence in Pseudomonas aeruginosa
… diverse and adaptable Gram-negative bacterial pathogen, with the ability to cause acute infections at multiple sites within human hosts. It is a leading cause of healthcare-associated infections worldwide, and is a leading cause of pulmonary infections in people with cystic fibrosis …
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Functional genomics of motile commensal intestinal bacteria
… flagellin, (the major protein component of the bacterial flagellar filament). Flagellate microbes can potentially stimulate the immune systems of mammals, and thus have significant immunomodulatory potential. The flagellum-biogenesis genotype and phenotype of Lactobacillus ruminis, an …
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Novel Perspectives on the Utilization of Chemotactic Salmonella Typhimurium VNP20009 as an Anticancer Agent
Attenuated bacterial strains have been investigated on the premise of selective tumor colonization and drug delivery potential for decades. Salmonella Typhimurium VNP20009 was derived from the parental strain 14028 through genetic modification and tumor targeting ability, being well studied for …
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