Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Bacterial keratitis"”.
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Role of the NLRP3 Inflammasome in bacterial keratitis
… of NLRP3 inflammasome in the pathogenesis of bacterial keratitis is not clearly understood. Macrophages play an important role in inflammation and infection and are known to produce the NLRP3 inflammasome. The NLRP3 inflammasome produces IL-1β a key pro-inflammatory mediator. The phenomenon of …
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The Transcriptional Regulation Of Flagellin-Induced Innate Protection Of The Cornea: Role Of Irf1 And Atf3
… markedly increased the severity of P. aeruginosa keratitis and significantly attenuated flagellin-elicited protection compared to WT controls at 3 dpi. CXCL10 neutralization in the cornea of WT mice displayed similar pathogenesis to that of IRF1-/- mice. To understand the regulation of CXCL10 …
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Surface Enhanced Raman Spectroscopy for Diagnostics in Ocular Health
… and treatment of ocular infections such as bacterial keratitis. However, challenges remain in managing biofilm composition variability and addressing spectral overlap with corneal tissue. Future work will focus on refining diagnostic algorithms to enhance accuracy and sensitivity, expanding …
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Epidemiology and microbiology of microbial keratitis in Queensland, Australia
Aim: Guide practitioners’ management of microbial keratitis (MK) by providing epidemiological information to define the disease and trends of MK in Queensland, Australia. Methods: This project studies MK through two databases to define and analyse the disease in Queensland. Databases used were the …
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Exploring the potential of UVC in treating superficial corneal infections
Microbial Keratitis (MK) is an acute, sight-threatening corneal infection. First line treatment for bacterial keratitis (BK) comprises topical antibiotics, either a dual therapy of fortified cephalosporin and aminoglycoside, or single fluoroquinolone therapy. Surveys describe increasing bacterial …
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Topical Nanoparticulate Formulation of Drugs for Ocular Keratitis
… employed in the treatment of ocular viral/bacterial keratitis. PART 1: Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NP) of dipeptide monoester prodrugs of ganciclovir (GCV) including L-Val-L-Val-GCV (LLGCV), L-Val-D-Val-GCV (LDGCV), D-Val-L-Val-GCV (DLGCV) were formulated and …