Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Bacterial Stress Response"”.
-
Strategies to potentiate bactericidal antimicrobial activity based on the suppression of bacterial stress response systems
… this expression may not affect the whole bacterial population equally. This phenomenon is known as heteroresistance. Heteroresistance is defined as the presence of a heterogeneous population of bacteria with one or multiple subpopulations showing higher levels of antimicrobial resistance …
-
A SYNTHETIC TMRNA PLATFORM FOR ELUCIDATION OF BACTERIAL PROTEOME REMODELING UNDER STRESS
… reprogramming is a key component of the bacterial stress response and is a function of mRNA stability, protein turnover and proteolysis. Total proteome measurements give a view of the stable proteome but can fail to capture dynamic changes under stress, including incomplete polypeptides …
-
Relative contributions of the stringent response mediators (p)ppGpp and DksA to Haemophilus ducreyi virulence in humans
… infection, H. ducreyi is subject to a variety of stresses. The stringent response is a bacterial stress response system induced by nutrient limiting conditions and mediated by guanosine tetra- and pentaphosphate [(p)ppGpp] and the transcriptional regulator DksA. (p)ppGpp and DksA jointly interact …
-
The Universal Stress Proteins of Micrococcus Luteus Are Metabolic Regulators That Confer Resistance to a Diverse Set of Stress Factors
The bacterial stress response systems have developed and evolved over the millennia to deal with the changing environmental conditions experienced by all the bacterial species. A common form of stress mitigation is the development of the dormant phenotype, a process by which bacteria enter a state …
-
An integrated approach to ciprofloxacin susceptibility analysis and high-throughput bacterial phenotyping in Salmonella
… Salmonella are a significant cause of bacterial infection globally, and the ST313 lineage of Salmonella Typhimurium are responsible for much of the burden of salmonellosis in sub-Saharan Africa. In recent years, there has been a drastic rise in multidrug resistance within this lineage, …
-
Studying the riboregulatory role of Hfq in Klebsiella pneumoniae using CLASH (crosslinking, ligation and sequencing of hybrids)
… are frequently exposed to different types of stresses, such as temperature fluctuations, osmotic pressure, pH variations, nutrient availability changes, attack by host immunity, exposure to free radicals and antibiotics. In response, microorganisms employ various mechanisms to adapt, repair …
-
The Development of a Bacterial Biosensor Designed to Detect Oxidative Chemicals in Water: Correlating Sensor Relevance to Mammalian Brain Cells and Assessing Bacterial Cell Immobilization Strategies
Oxidative stress-inducing chemical contamination in the environment is a significant concern for public health. The depletion of antioxidants by these chemicals results in oxidative stress which may cause detrimental effects in many cell types. For example, multiple stress responses may be …
-
Structural and Functional Studies of the Unconventional Proteobacterial Transcription Activator Crl in Complex with the Transcription Machinery
… RNA polymerase (RNAP) is the master regulator of stress responses in many Gram-negative bacteria. This alternative σ factor assembles with the core RNA polymerase to initiate the transcription of genes needed to survive different environmental changes. Crl is a small protein that activates the …
-
The Functional Characterization of the LysR-Type Transcriptional Regulator QseD and the SorC-Type Transcriptional Regulator LsrR in Enterohemorrhagic Escherichia coli
… density and diversity through the recognition of bacterially produced autoinducers (AI) AI-2, and 3 by LsrR, and QseBC respectively [1, 3]. Through the interpretation and integration of these multiple regulatory signaling networks that often involve intracellular regulatory proteins, such as the …
-
Elucidating the Response of Activated Sludge Cultures to Toxic Chemicals at the Process, Floc and Metabolic Scales
… are interdependent, in the sense that specific bacterial stress response mechanisms (physiological mechanisms that protect the cell from toxic conditions) may lead to physical/chemical alterations at the floc level, and vice-versa. Ultimately, understanding the mechanisms that occur at the floc …
-
How bacteria tune mixed positive/negative feedback loops to generate diverse gene expression dynamics
… exist in great diversity, both within and across bacterial species. Recent advances in single-cell experimental techniques have enabled studies of alternative sigma factor responses in individual cells, revealing a range of possible behaviours. These are often heterogeneous across isogenic …