Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Bacterial Persistence"”.
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Population dynamics of bacterial persistence
… differently under identical environments. Bacterial persistence is a prime example of such phenotypic heterogeneity, whereby a population survives under an antibiotic attack, by keeping a fraction of population in a drug tolerant state, the persister state. Specifically, persister cells …
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Lost in Starvation: How the interplay between physiology and ecology impacts bacterial persistence in a patchy landscape
… navigate a heterogeneous landscape of resources. Bacterial populations cycle through periods of feasting when attached to nutrient particles and periods of famine when foraging between hotspots; thus, bacterial physiological states and ecological processes are intertwined. The stress response to …
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Recurrent Urinary Tract Infections Due to Bacterial Persistence or Reinfection in Women: Does This Factor Impact Upper Tract Imaging Findings? A Quality Improvement Project
… urinary tract infections (RUTIs) due to bacterial persistence (same strain) undergo upper urinary tract imaging to evaluate for sources of their infection. OBJECTIVE: To compare the rate of upper tract imaging abnormalities between RUTIs due to bacterial persistence or reinfection. …
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The Role of Bps Polysaccharide in Bordetella Resistance to Host Innate Defenses
… defenses. Biofilms have been proposed to promote bacterial persistence by suppressing the effectiveness of host responses. A hallmark of mature biofilms is the production of a matrix composed of extracellular polymers including proteins, DNA and polysaccharides. We have shown that the …
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Systems analysis and characterization of mucosal immunity
… develop complex immune responses to cope with bacterial persistence. Depending on a variety of host and microbe factors, outcomes range from peaceful co-existence to detrimental disease. Mechanisms underlying immunity to bacterial stimuli span several spatiotemporal magnitudes and the summation …
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Differential Expression Analysis of Type II Toxin-Antitoxin Genes of Pseudomonas aeruginosa PAO1 under Different Environmental Conditions
Bacterial persistence is considered as one of the primary reason for antibiotic tolerance besides genetically acquired antibiotic resistance. Persisters are the subpopulation of a clonal bacterial population, which can survive environmental extremes and become invulnerable to stresses due to …
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Transdisciplinary Strategies for the Characterization of Mucosal Immune Responses to Enteric Pathogens
… effector inflammatory responses required for bacterial clearance thus favoring tolerance over immunity, iv) intracellular mechanisms of immune evasion that contribute to bacterial persistence and chronic infection. The knowledge generated throughout this dissertation exemplifies how a …
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The effect of e-liquids and electronic cigarette vapour extract (ECVE) on key respiratory pathogens
… study have shown that neat e-liquids can reduce bacterial viability with particular flavours causing significant reductions in bacterial viability. It was found that e-liquids contained numerous chemical compounds some of which had antimicrobial properties. The greater the number of chemical …
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Mobile genetic elements in Coxiella burnetii: Friends, foes or just indifferent?
… and able to inhibit ribosome function and retard bacterial growth through internal guide sequence (IGS)-dependent and -independent mechanisms. The introns were found to be highly conserved in all eight genomic groups of C. burnetii, suggesting a role in C. burnetii's biology. It is not clear …
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Mobile genetic elements in Coxiella burnetii: Friends, foes or just indifferent?
… and able to inhibit ribosome function and retard bacterial growth through internal guide sequence (IGS)-dependent and -independent mechanisms. The introns were found to be highly conserved in all eight genomic groups of C. burnetii, suggesting a role in C. burnetii's biology. It is not clear …
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Evolution and phenotypic diversification in serratia marcescens biofilms
… of phenotypic diversification during bacterial pathogenesis and bacterial persistence. Characterization of the microcolony biofilm development of S. marcescens revealed that the S. marcescens biofilm develops through a process involving microcolony formation, hollowing of mature …
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Electrochemical Control of Bacterial Persister Cells
… infection control. Conventional methods of antibacterial treatment involving high dose of antibiotics or surgical intervention have proven insufficient for eradicating persistent infections, such as those associated with medical implants. It is well recognized that bacterial populations commonly …
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The molecular characterisation of the recA locus in the opportunistic pathogen Bacteroides fragilis
… anaerobic bacterium of pathogenic potential and bacterial persistence in the oxygen rich peritoneal cavity. The aim of this thesis was to characterise the B. fragilis recA gene cluster with respect to its genomic context and the transcriptional regulation of the genes in response to metronidazole …
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Ion channel modulation during Chlamydia trachomatis development
Summary The obligate intracellular bacterial pathogen Chlamydia trachomatis causes sexually transmitted and ophthalmic infections (trachoma) in humans. C. trachomatis resides within a specialised membrane-bound replicative compartment termed the inclusion and exhibits a biphasic lifecycle requiring …
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Transcriptional stress response in foodborne pathogens
… in the food industry, yet the mechanism of bacterial inactivation has not been fully elucidated. Here, we examined the response of <em>Listeria monocytogenes</em> to sublethal concentrations of aqueous ClO<sub>2</sub> was assessed. <em>L. monocytogenes</em>was grown to early log phase in BHI …