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Showing 1 to 6 of 6 for “"Bacterial Outer Membrane Proteins"”.
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Development of Computational Antibiotic Screening Platform Across Bacterial Outer Membrane Proteins
<p>Antibiotics are medicines used to treat bacterial infections by either killing bacteria or stopping them from reproducing. Throughout the use of antibiotics, bacteria has developed a variety of defense mechanisms against antibiotics and thus diminishing their effectiveness. Antibiotic resistance …
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Biofilm Formation by Moraxella Catarrhalis
… biofilm formation in vitro by the Gram-negative bacterial pathogen Moraxella catarrhalis. Growth of M. catarrhalis in a continuous-culture biofilm system resulted in little detectable change in outer membrane protein production compared to broth-grown M. catarrhalis. Biofilm-grown M. catarrhalis …
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Characterization of novel virulence factors of Shigella flexneri and development of Caenorhabditis elegans as an animal model for Shigella infection
… vaccine is ongoing. A thorough understanding of bacterial pathogenesis is paramount for the development of an effective vaccine. To this end the aim of this thesis is to further our understanding of S. flexneri pathogenesis by characterizing novel virulence factors and to develop a new animal …
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Characterization of novel virulence factors of Shigella flexneri and development of Caenorhabditis elegans as an animal model for Shigella infection
… vaccine is ongoing. A thorough understanding of bacterial pathogenesis is paramount for the development of an effective vaccine. To this end the aim of this thesis is to further our understanding of S. flexneri pathogenesis by characterizing novel virulence factors and to develop a new animal …
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Identification of bptA (bbe16) as an Essential Gene for the Persistence of the Lyme Disease Spirochete, Borrelia Burgdorferi, in its Natural Tick Vector
… lipoprotein and was surface-exposed on the outer membrane of B. burgdorferi. Moreover, BptA also was shown to be highly conserved in all B. burgdorferi sensu lato strains tested, suggesting that BptA may be widely utilized by Lyme borreliosis spirochetes for persistence in nature. Given B. …
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Decomposition of Proteins into Functionally and Evolutionarily Independent Cooperative Units
Understanding cooperative interactions within proteins is an important goal because cooperativity underlies protein functions such as catalysis, allostery, ligand binding and folding. Cooperative units within proteins can be revealed via an evolution based method called statistical coupling …