Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Bacterial Collagenase"”.
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Improving the delivery and efficacy of molecular medicine via extracellular matrix modulation : insights from intravital microscopy
… the tumor collagen matrix directly with purified bacterial collagenase, or indirectly with relaxin treatment, resulted in increased diffusion coefficients of macromolecules within tumors in vivo. In order to quantitate the changes in collagen content and structure induced by relaxin treatment, we …
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A Lorentz-force actuated controllable needle-free drug delivery system
… and in-vivo testing on murine tissue using a bacterial collagenase.
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Human neural stem cells over-expressing Akt1 provide cytoprotection and functional recovery in mouse stroke model
… induced in adult mice by unilateral injection of bacterial collagenase into striatum and then, we transplanted F3 and F3.Akt1 hNSCs into the animal brain. Transplantation of F3.Akt1 hNSCs increased survival of grafted cells by 0.5 ？ 2 fold at two weeks and eight weeks, and induced behavioral …
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Improving the delivery and efficacy of a cancer therapeutic via extracellular matrix modification
… by collagen. Degradation of tumor collagen with bacterial collagenase enhanced the distribution and efficacy of the virus. To develop a technique that is clinically applicable, human collagenases were screened for similar activity. Matrix metalloproteinase (MMP) -1 and -8 were identified as …
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Photodynamically Activated Multifunctional Chitosan Nanoparticles to Disinfect and Improve Structural Stability of Dentin
… elimination of bacteria and prevention of bacterial recolonization in the root canal system. The major challenge for conventional root canal disinfection strategies is the ability of bacteria to persist as biofilms within the anatomical complexities of the root canal system. In addition, …
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Development of Collagen Mimetic Mini-Fibrils with Tunable Collagenase Susceptibility
… I first studied the interactions of MMP1 and the bacterial collagenase ColG with native type I collagen. Kinetic assays of the enzyme reactions revealed that the triple helix was the most susceptible conformation of collagen to MMP1, while the degradation of the fibrillar form or the unfolded form …
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Elucidating Collagen Degradation Synergy between Col G and Col H from Hathewaya (Clostridium) histolytica and Identifying novel structural features in HPT and REC domains from VarS histidine kinase in V. alginolyticus
… by which Hathewaya (Clostridia) histolytica collagenases are secreted and work together to degrade collagens are investigated. While H. histolytica collagenases Col G and Col H have similar multi-domain structures the difference in number of and orientation of the domains hint that the two …