Global ETD Search
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Showing 1 to 8 of 8 for “"Bacterial Cell Envelope"”.
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Nonlinear electrokinetics of the bacterial cell envelope for applications in biomicrofluidics
… for the electrokinetic ion transport around bacterial cell envelope under the influence of externally applied electric fields. The ability to understand the physics of this ion transport has experimental applications in cell envelope phenotyping of bacteria, cell sorting, intracellular …
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Conformational Rearrangements In The Sensory Rcsf/Omp Complex Mediate Signal Transduction Across The Bacterial Cell Envelope
<p>Timely detection and repair of envelope damage are paramount for bacterial survival. The Regulator of Capsule Synthesis (Rcs) stress response is a complex signaling cascade that monitors gram-negative cell envelope integrity and can transduce the stress signals across the multilayered envelope …
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Computational investigation of membrane proteins across species and functional classes
Membrane proteins play central roles in cellular communication, metabolism, and homeostasis, yet experimental characterization of their dynamic interactions with membranes remains highly challenging. In this dissertation, I implement advanced molecular dynamics (MD) simulation workflows to …
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Brucella abortus Strain RB51 Outer Membrane Vesicles as a Vaccine Against Brucellosis in a Murine Model
Brucella abortus is a zoonotic agent that primarily infects cattle and causes brucellosis. B. abortus strain RB51 is a live, attenuated vaccine licensed for cattle. However, there is no available vaccine to prevent human brucellosis. Outer membrane vesicles have been tested as potential vaccines to …
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Role of Bacterial Lipocalin Proteins in Antimicrobial Resistance
… patients with cystic fibrosis, produces the extracellular bacterial lipocalin protein BcnA upon exposure to<br/>sublethal concentrations of bactericidal antibiotics. BcnA captures a range of antibiotics outside bacterial cells, providing a global extracellular mechanism of antimicrobial …
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Electrical-phenotyping of the bacterial envelope using microfluidics
The bacterial cell envelope is a complex multi-layered covering, crucial for cell viability and physiological capabilities. Phenotypic analysis of bacterial envelopes is challenging due to the small size and low cultivability of microbes. The emerging microfluidic techniques enable quantitative and …
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Molecular recognition, in- and out- of equilibrium, in the actions of bacterial multidrug efflux nanomachines
… infections is outpacing the provision of new antibacterial treatments and leading to a growing health and economic burden. One of the main mechanisms that bacteria use to acquire drug resistance is through the expression of multidrug efflux transporters. Among the many efflux pumps present in …
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The Biogenesis and Homeostasis of the Shigella flexneri Cell Envelope
… devastating the paediatric age group. This bacterial pathogen synthesises a plethora of polysaccharide-based complexes on its cell surface, such as lipopolysaccharide (LPS), that facilitate host cell adhesion, and influence key immunomodulatory responses. LPS is comprised of three distinct …