Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Bacteria-based cancer therapy"”.
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Biomanufacturing of Bacteria-Mediated Drug Delivery Systems and Investigation of Their Interaction with the Tumor Microenvironment
The limited transport of conventional chemotherapy within the tumor microenvironment (TME) is due to irregular vascularization, increased tumor interstitial pressure, and a dense extracellular matrix (ECM). The lack of selectivity of anticancer drugs often leads to systemic toxicity and damage to …
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Bacteria - Hydrogel Interactions: Mechanistic Insights via Microelastography and Deep Learning
Bacteria-based cancer therapy (BBCT) holds immense promise in addressing the limitations in treatment of solid tumors. Bacterial strains used for BBCT are engineered to express therapeutics, facilitate precise navigation within the tumor microenvironment by enhancing bacteria's motility, chemotaxis …
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Rational Engineering of Bacteria and Biohybrids for Enhanced Transport and Colonization in the Tumor Microenvironment
… to the broad success of conventional chemotherapy is poor delivery to and transport within the tumor microenvironment (TME), caused by irregular and leaky vasculature, the lack of functional lymphatics, and underscored by the overproduction of extracellular matrix (ECM) proteins such as …
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Engineering Tumor-Targeting Bacteria and Characterizing Their Interactions with Tumor Cells in Therapy-Resistant Breast Cancers
Breast cancer (BC) accounts for one-third of malignancies among women in 157 countries and ~15% mortality among diagnosed cases, a burden projected to reach 1.1 million deaths per year by 2050. Five-year survival drops from >90% in early-stage BC to ~32% for therapy-resistant subtypes such as …