Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Baclofen"”.
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Separation of enantiomers of Baclofen
(3-(Aminomethyl)-4-chlorobenzenepropanoic acid (Baclofen), 3-(p-chlorophenyl)pyrrolidone (Baclofen lactam) and 3-(p-Chlorophenyl)glutaramide (baclofen's synthetic precursor) were individually used as substrates in co-crystallisation experiments with several resolving agents. Experiments were …
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Psychosocial Variables in Outpatients Receiving Intrathecal Baclofen or Pain-Pump Therapy
… functioning, and quality of life. Intrathecal baclofen and pain pump therapy have been viable treatment options for those patients with severe spasticity who have not responded to less invasive treatments. Several small studies have examined quality of life and patient-reported efficacy for …
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EFFECTS OF BACLOFEN AND PHENMETRAZINE ON NEURONAL SIGNALING PATHWAYS IMPLICATED IN PSYCHOSTIMULANT ADDICTION
Substance use disorders (SUDs) and addictions are serious mental conditions with profound consequences on both an individual and society. In the United States alone, the total estimated cost of substance abuse, including lost productivity-, crime-, and health- related costs, exceeds $700 billion …
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Regulation of Luteinizing Hormone and Catecholamine Release
… barbiturate, phenobarbital, the GABAg agonist, baclofen, the GABA^ agonist, muscimol, or either the GABA^ antagonist, bicuculline, or the putative GABAg antagonist, 5-aminovalerate. Additional experiments tested the effects of the GABA drugs on LH release in ovariectomized, hormonally untreated …
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Pharmacological control of transient lower oesophageal sphincter relaxations / Ilmars Lidums.
… anticholinergic agents and the GABAb agonist, baclofen.
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Gabab Regulation of Methamphetamine-Induced Associative Learning
… of the direct acting GABAB receptor agonist baclofen has revealed positive outcomes in clinical trials; however, the side effects associated with baclofen limit its clinical utility. Positive allosteric modulators (PAMs) of the GABAB receptor augment GABAB receptor signaling without the side …
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Ethanol Enhancement of Two Distinct Inhibitory Pathways in the Rat Basolateral Amygdala: Implications for Anxiety and Alcoholism
… agonist activation of GABAB autoreceptors by baclofen could inhibit both local and lpcs synapses to a similar extent, baclofen pretreatment could only inhibit EtOH potentiation of local synapses. The effects of EtOH and GABAB modulators on spontaneous/miniature IPSCs mimicked that of local …
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The role of ventrolateral prefrontal cortex in performance of spatial self-ordered response sequences in the marmoset
… that local inactivation of vlPFC using muscimol/baclofen infusions impairs sequencing. This effect was shown to be selective to performance of sequences that varied spatially from trial to trial; thus, no effects of vlPFC inactivation were observed for performance of a fixed response sequence. …
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Neurochemical and Neuroanatomical Basis Of Reversal Learning In The Rat
… of these structures via infusion of a muscimol/baclofen mixture produced dissociable effects. Inactivation of the infralimbic cortex led to a significant general improvement in reversal learning regardless of phase, while inactivation of the medial orbitofrontal cortex led specifically to a …
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Non-invasive assessment of gastrointestinal function using breath test technology : investigations in health and disease.
… stomach inflammation caused dysmotility; (2) baclofen (a potential reflux therapy) accelerated gastric emptying of solids and delayed liquid emptying in a dosedependent manner; and (3) mice with a high daily food intake had faster emptying compared to those with low intake, which resulted in …
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The Behavioral Effects of Temporary Inactivation of the Lateral Habenula on Free Feeding
Overconsumption, or eating beyond the point of homeostasis, is a key feature in the development of obesity. Although people are consuming beyond the point of homeostasis, they are not consuming constantly or indefinitely. Thus, there is likely a mechanism that acts to terminate periods of food …
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Effects of specifically sequenced massage on spastic muscle properties and motor skills in adolescents with cerebral palsy
… include botulinum toxin injections, intrathecal baclofen, selective dorsal rhizotomy and multi-level orthopaedic surgery. Despite these varied and concerted inputs, improvements in motor skills are very limited – motor skills tend to plateau around the age of seven and in fact deteriorate in …
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Competency Guide For Intrathecal Pump Nurses
… quality care for patients who have Intrathecal Baclofen Therapy (ITB) and Intrathecal Pain Therapy (ITP). The intrathecal pump therapy has been used for many years and if not done effectively complications can be fatal.</p> <p>Programming errors, administering incorrect medication …
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Characterization of Rimonabant effects on G protein activity
… were performed to evaluate the effects of SR on baclofen and quinpirole-induced outward K+ current both in wild-type (WT) and CB1-KO mice. In addition, in order to demonstrate that SR induced the inhibition of GIRK channel activity by acting directly on G protein, we use a GPCR-free experimental …
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Modelling the Neuropsychopharmacology of Obsessive-Compulsive Disorder in the Common Marmoset (Callithrix jacchus)
… inactivated using GABAA–GABAB agonists (muscimol–baclofen). Whereas the pgACC inactivation produced selective deficits in sensitivity to action–outcome contingency degradation, OFC inactivation reduced the suppressive effect of noncontingent reward on responding more generally but left intact …
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Design, synthesis and pharmacological evaluation of certain GABAB agonists
… der Aktivität von Analogen und Homologen des Baclofens abgeleitet. Letztendlich wurde ein Pharmakophor-Modell für GABAB Agonisten mit DISCO (DIStance COmparisons) Programm erstellt.