Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Bacillus Calmette–Guérin (BCG)"”.
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Study of phenotypic and gene expression response to bacterial challenge
In the mouse model of Bacillus Calmette-Guérin (BCG)-induced inflammation, focus is placed upon phenotypic and gene-expression responses to the original challenge. Studies of the phenotypic response to BCG involves several behavior indicators, categorized as representing an initial period of …
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Study of proteins after recovery from bacterial infection
The effect of Bacillus Calmette–Guérin (BCG) on the microglia of mice after recovery from infection is incompletely understood. Microglia cells of mice were collected from two groups, mice infected with BCG vs. control mice (BCG vs. control). The objective of this study was to compare the proteins …
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Mapping and modeling macrophages in tuberculosis
… macrophage and other immune cell states after Bacillus Calmette–Guérin (BCG) vaccination in non-human primates and identify molecular features associated with protective responses. Lastly, we conclude by exploring how profiling and modeling ligand and genetic perturbations in macrophages can …
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Effect of Systemic Versus Localized Bacillus Calmette-Guérin Immunotherapy on Bladder Cancer Progression: Novel Role for Trained Immunity
… (NMIBC) involves intravesical immunotherapy with Bacillus Calmette Guérin (BCG). Unfortunately, most patients do not respond fully to this therapy, and our understanding of the immunotherapeutic effect of BCG is incomplete. The tumor immune microenvironment (TiME) is known to influence responses …
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The development of novel HIV-1 vaccines using modified recombinant BCG
… novel HIV-1 vaccine vectors, such as modified BCG, combined with modified vaccinia Ankara in the context of heterologous prime boost regimes. The tuberculosis vaccine Bacillus Calmette–Guérin (BCG) has a wellestablished safety profile as well as notable adjuvant activity with an estimated 3 …
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Optimisation of a flow cytometry antibody panel to detect BCG-induced innate responses in infants
… human immunodeficiency virus (HIV) and previous Bacillus Calmette–Guérin (BCG) vaccination. As it stands, other than inborn errors in key mycobacterial susceptibility genes both animal and human studies have not found many genetic polymorphisms that are strongly and reproducibly associated with …
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Effects of voluntary wheel running and forced treadmill running on inflammation induced behavioral abnormalities in young and old mice
… running on lipopolysaccharide (LPS) and Bacillus Calmette-Guérin (BCG) induced sickness behavior (food intake, fluid intake, body weight, locomotor activity), depressive-like behavior (tail suspension test, sucrose preference), and activation of brain cytokine signaling pathways in young …
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Influence of gut microbiota on immune system in infants
… from blood samples that were stimulated by a Bacillus Calmette–Guérin (BCG) antigen and correlated with microbiota compositions. Results and Conclusion: Microbiome data showed initial differentiation between breast and mixed fed infants.15% of 5 of the most abundant bacteria for breast fed …
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Human Inborn Errors of Immunity: Tuberculosis, Autoimmunity, and Beyond
… deadliest infectious diseases in human history. Bacillus Calmette-Guérin (BCG) vaccine, first implemented medically in 1921, has remained the only available vaccine for TB, although its protective effect is moderate. TB occurs in 5-10% of individuals exposed to those pathogens, while 90-95% …
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Correlates of tuberculosis and non-tuberculosis morbidity and immunity in sub-Saharan African HIV-exposed, uninfected infants
… their altered immunity and/or gut microbiota. Bacillus Calmette-Guérin (BCG) vaccination is an effective intervention to prevent severe tuberculosis (TB) disease in children. BCG vaccination also enhances heterologous protective immunity against infections through epigenetic reprogramming of …