Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"BZLF1"”.
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Locus-specific proteomics identifies novel repressors of Epstein-Barr virus reactivation
… repression is the immediate-early lytic gene BZLF1, whose expression can activate the entire lytic cascade. Our understanding of the factors which restrict BZLF1 expression is incomplete and the aim of my project was to use PICh (Proteomics of Isolated Chromatin segments), a novel locus- …
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Überexpression von s-Adenosylhomocysteinhydrolase in Epstein-Barr-Virus-positiven Burkitt-Lymphomzellen
… (IFT) - the PCR-products of BZLF1 and BHRF1 the first day after transfection - the increase of DNA-synthesis two days after transfection - unchanged growth in comparison to the control cells - an increased expression of CD 19, CD21, CD40 and CD58 - no change in the activity of …
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Überexpression von s-Adenosylhomocystein-Hydrolase (SAH) in Zellen der Epstein-Barr Virus-Genom positiven Zell-Linie B95-8
… increased expression of the viral genes EA-D and BZLF1 was shown by immunofluorescence assay and PCR. The transfection with SAH led to an increase of phosphorylated and activated protein kinase C (PKC). The lytic cycle might be activated additionally using a PKC and PLA2 independent way.The rate …
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Immunpathologische Folgen von Infektionen des ZNS durch das lymphotrope Maus-Herpesvirus 68 als Modell für Epstein-Barr-Virus assoziierte ZNS-Erkrankungen des Menschen
… fulfil this function alone as the product of the BZLF1-gene is also necessary. There is no homologous BZLF1 gene product known for MHV-68. An important part of this dissertation was to map the regulation of the G50/Rta-promoter. The regulation of the BRLF1/Rta-promoter is widely known. If the …
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Einfluss der MAP-Kinase ERK3 (p97) auf EBV-positive Burkitt-Lymphom-Zellen
… were detected by different parameters as BZLF1, EA (early antigen), cell proliferation and DNA-synthesis rate. A clear activation of the viral lytic cycle was observed. In further experiments the connection between ERK3 (p97) and the related MAP-kinase ERK3 (p63) and the Proteinkinase C …
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CHARACTERIZATION OF HUMORAL RESPONSE TO EPSTEIN-BARR VIRUS (EBV) INFECTION AND PROTEIN KINASES INVOLVED IN VIRAL REPLICATION
… BdRF1, BLRF2, EBNA-3A, EBNA-3B, BHRF1, and BZLF1). I have also identified 5 novel immunodominant viral antigens (BPLF1, BKRF4, BRRF2, BLLF3, and BSLF2/BMLF1) that have never been described as major antigens of EBV. In addition, I have confirmed previous observations that the antibody …
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Reaktion des Epstein-Barr-Virus und seiner Wirtszelle B95-8 auf die Überexpression der extrazellulär-regulierten Kinase 3 (p97)
The activation of the Epstein-Barr virus (EBV) lytic cycle is of significant importance for the viral pathogenesis. Until now the molecular mechanisms resulting in EBV-reactivation under physiological conditions are not fully understood.It is known that stimulation of the EBV genome-positive …