Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"BXD mice"”.
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Investigating Potential Quantitative Trait Loci for Susceptibility to Experimental Autoimmune Encephalomyelitis in the BXD Family of Mice
… histocompatibility complex. By utilizing the BXD family of mice, we investigated genetic factors that affect a BXD strain’s susceptibility to EAE, an inducible disease model for MS. We induced EAE in several BXD mice strains via an emulsion of complete Freund’s adjuvant and MOG35-55, and then …
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Genetic Control of Survival and Weight Loss during Pneumonic Burkholderia pseudomallei (Bp) Infection
… for some time that inbred and recombinant inbred mice exhibit differences in susceptibility to many intracellular pathogens and are thought to provide excellent models for acute and chronic human melioidosis. Therefore, this project set out to identify host genetic elements that contribute to …
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Effects of Genetics and Sex on Hippocampal Gene Expression and Adolescent Behaviors Following Neonatal Ethanol Exposure in BXD Recombinant Inbred Mice
… call death in the hippocampus using fourteen BXD strains and the two parental strains. The goal of the present study was to examine the effect of genetics and sex on differential gene expression changes and behavioral responses in animals exposed to postnatal ethanol.</p> <p>To test this, we …
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Identification of Therapeutic Targets for Th17 Cell-Mediated Diseases
… T cell response. Data from mouse inbred lines of BXD family were analyzed to identify the genes involved in susceptibility to HP and were used in the study of the mechanisms by which they contribute to the disease. We found that BXD strains exhibited variability in the T cell response to the …
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Systems Biology Approach to Identifying Host Interactive Pathways Modulating the Severity of Streptococcal Sepsis
… the Advanced Recombinant Inbred (ARI) panel of BXD mouse strains. We used this panel of ARI-BXD strains as a genetically diverse reference population to study differential severity of GAS sepsis as ARI-BXD strains diversity mimics the genetic diversity of human population. We assessed several …