Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"BXD"”.
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Bone Properties of Recombinant Inbred Line - BXD Mouse
… of quantitative traits and gene function, BXD recombinant inbred (RI) lines mice have been used to identify genetic effects for bone density.</p> <p>For the first time, we investigated the bone properties of BXD RI mice by analyzing femur and tibia and compared their phenotypes of different …
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Systems Genetics and Systems Biology Analysis of Paraquat Effects in BXD Recombinant Inbred Mice
… injury in substantia nigra in a subset of the BXD panel using immunohistochemistry. Thus, the approach would be to do an unbiased quantification of the number of tyrosine hydroxylase positive (TH+) cells in the SNpc in a subset of the BXD panel exposed to paraquat or saline. The hypothesis is …
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Investigating Potential Quantitative Trait Loci for Susceptibility to Experimental Autoimmune Encephalomyelitis in the BXD Family of Mice
… histocompatibility complex. By utilizing the BXD family of mice, we investigated genetic factors that affect a BXD strain’s susceptibility to EAE, an inducible disease model for MS. We induced EAE in several BXD mice strains via an emulsion of complete Freund’s adjuvant and MOG35-55, and then …
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Effects of Genetics and Sex on Hippocampal Gene Expression and Adolescent Behaviors Following Neonatal Ethanol Exposure in BXD Recombinant Inbred Mice
… call death in the hippocampus using fourteen BXD strains and the two parental strains. The goal of the present study was to examine the effect of genetics and sex on differential gene expression changes and behavioral responses in animals exposed to postnatal ethanol.</p> <p>To test this, we …
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Systems Biology Approach to Identifying Host Interactive Pathways Modulating the Severity of Streptococcal Sepsis
… the Advanced Recombinant Inbred (ARI) panel of BXD mouse strains. We used this panel of ARI-BXD strains as a genetically diverse reference population to study differential severity of GAS sepsis as ARI-BXD strains diversity mimics the genetic diversity of human population. We assessed several …
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Functional Analysis of Genomic Variation and Impact on Molecular and Higher Order Phenotypes
… of mice—DBA/2J—the father of the large family of BXD recombinant inbred strains. We analyzed ~100X wholegenome sequence data for the DBA/2J strain, relative to C57BL/6J, the reference strain for all mouse genomics and the mother of the BXD family. We generated the most detailed picture of …
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Genetic Control of Survival and Weight Loss during Pneumonic Burkholderia pseudomallei (Bp) Infection
… dangerous and emerging pathogen using inbred and BXD mouse strains as an in vivo modeling system of melioidosis.</p> <p>We have utilized recombinant inbred BXD mice and a powerful array of complementary computer-based modeling algorithms and databases collectively known as GeneNetwork. We infected …
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Multiscale Genomic Analysis of the Corticolimbic System: Uncovering the Molecular and Anatomic Substrates of Anxiety-Related Behavior
… limbic system that controls emotionality. Using BXD recombinant inbred (RI) mice as model organisms, the anatomy and cellular architecture of the amygdala—specifically, the basolateral amygdala (BLA)—was examined to assess the level of structural variation in this brain region. Quantitative trait …
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Identification of Therapeutic Targets for Th17 Cell-Mediated Diseases
… T cell response. Data from mouse inbred lines of BXD family were analyzed to identify the genes involved in susceptibility to HP and were used in the study of the mechanisms by which they contribute to the disease. We found that BXD strains exhibited variability in the T cell response to the …
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Using Genetic Diversity to Understand Susceptibility to Cognitive Decline in Aging and Alzheimer’s Disease
… we turned to genetically diverse mice from the BXD genetic reference panel (GRP) to overcome some of the barriers traditionally associated with human studies. Using a forward genetics screen, we first identified and validated the gene heterochromatin protein l binding protein 3 (<em>Hp1bp3</em>) …
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Genetic Analysis of Variation in Neuron Number
… brain weight using two recombinant inbred sets (BXD and AXB/BXA) and one F2 intercross (ABXDF2, n = 517. Using linkage analysis, with composite interval mapping, I detected four significant QTLs affecting brain weight on Chrs 7, 11, and 14. The brain weight QTLs have been named Brain size control …
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Multipronged Approach to Study Glaucoma-Associated Phenotypes
… genetic modifiers of IOP using the enlarged BXD family of strains in combination with human GWAS glaucoma cohorts. This will pave the way for improved drug development tailored to individual genotypes for POAG. Second, we have combined systems genetics, bidirectional studies using multiple …
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Discoveries of Targets and Novel Agents for the Treatment of Ischemic Retinopathy and Neovascular Disease
… resistance in the genetically diverse, murine BXD strains using a total-body irradiation (TBI) model. Our studies suggested mean survival time (MST) over 30 days may in fact be related to genetic variation in genes associated with endothelial progenitor cells (EPC) localization, wound healing, …
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Myelin Gene Expression: Implications for Alcohol Abuse and Dependence
… Bioinformatics of basal MAGE across the BXD recombinant inbred panel (n=29), derived from B6 and D2 mice, revealed a densely correlated myelin gene network associated with several ethanol behavioral phenotypes. Literature association tools identified Fyn kinase as potential regulator of …
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Genetic Variation and Sex Mediate Differential Responses to ∆-9-tetrahydrocannabinol among Inbred Mice
… our study of THC response variation to the BXD genetic reference population derived from B6 and D2 strains. Increasing the number of strains tested by tenfold (N=20) we detect significant strain and sex variation in THC response and use online tools to perform QTL mapping and correlation …