Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"BTK"”.
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Generalization of the BTK Theory to the Case of Finite Quasiparticle Lifetimes
A generalization to the BTK theory is developed based on the fact that the quasiparticle lifetime is finite as a result of the damping caused by the interactions. For this purpose, appropriate self-energy expressions and wave functions are inserted into the strong coupling version of the Bogoliubov …
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BTK functions as a corepressor of Nurr1 in human neural stem cells
… 새로운 cofactor를 유도하여 complex를 형성하게되는데 미분화신경줄기세포에서는 BTK를 분화세포에서는 PARP를 유도한다.
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Molecular determinants regulating Bruton’s tyrosine kinase activity and their mechanism: a combined computational and experimental approach
… kinase called Bruton’s tyrosine kinase or Btk. Btk is a member of the immune signaling pathway in B-cells and is required for B-cells maturation and function.</p> <p>Lack of a three-dimensional structure of full-length Btk kinase has proved a roadblock in understanding how the domains in …
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Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus
… production. Bruton’s tyrosine kinase (Btk), which is critical to B cell receptor (BCR) signaling, mediates BCR hypersensitivity and autoantibody production in lyn-/- mice. B cell hyperresponsiveness is not, however, sufficient for the autoimmune phenotype; additional Btk-dependent …
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Conductance of Superconductor -Normal Metal Contact Junction Beyond Quasiclassical Approximation
… the system does not differ much from the simple BTK model. We have thus shown the reason for robustness of BTK model, and gained a better view of what might be the cause of larger discrepancies between this simple model and experiment.
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Exploring the role of IRF4 in the sensitivity of mantle cell lymphoma cells to Bruton's Tyrosine Kinase inhibitors
… Therapy using Bruton’s tyrosine kinase (BTK) inhibitors has improved clinical outcomes but primary and secondary resistance to BTK inhibitor (BTKi) therapy affects more than half of MCL patients. Resistance most often arises through gene mutations in cells protected from BTKi effects …
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QUANTITATIVE PROTEOMIC APPROACHES TO STUDY DRUG MECHANISM OF ACTION
… inhibitor of the tyrosine protein kinase BTK, approved by FDA in 2013 for the treatment of B cell malignancies. We used ibrutinib as case study, but the developed protocols can be applied to the study of other covalent inhibitors. Target engagement conditions were initially optimized on …
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A kábítószerrel való visszaélés egyes kérdései
… kábítószerrel való visszaélés Btk-beli tényállásával,a függőség kialakulásának okaival,az Európai Unió és az Amerikai Egyesült Államok kábítószerpolitikájával,valamint a prevencióval és a debreceni kábtószerfogyasztás jellemzőivel.
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Development of novel lysine targeting covalent inhibitors for Bruton’s tyrosine kinase and casein kinase 2 and synthesis of novel hybrid androgen receptor inhibitors
… covalent inhibitors, targeting the PH domain of BTK, a previously unreported targeting strategy. 3 families of analogues were rapidly constructed using an efficient 4 step synthetic strategy, yielding 23 analogues and 14 co-crystal structures with the BTK PH domain. The high percentage of crystal …
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CD180/RP105 Toll-like Receptor (TLR) mediated signalling in Chronic Lymphocytic Leukaemia
… with the BCR signalling pathway: PI3K, Btk, ERK, p38MAPK and AKT. Segregation of CLL samples responding to CD180 ligation by signalling via pAKT, rather than by CD86 upregulation, revealed that CD180 ligation on CLL cells can activate two alternative signalling pathways: pro-survival …
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Functional interaction between CD180 Toll-like receptor (TLR) and B cell receptor (BCR) in the biology of Chronic Lymphocytic Leukaemia (CLL)
… through activation of protein kinases (PK) BTK-AKT (AKT-signallers); and the second - predominantly pro-apoptotic, operating through activation of p38MAPK (p38MAPK-signalers) but not through BTK. This may have implications for CLL therapy where BTK inhibitors are being used. To assess …
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Signal transduction in macrophages. Intracellular pathways activated by microbial constituents
… from the Src family (SFK) and the Tec kinase Btk. in signaling pathways induced by microbial constituents. SFK are important in bacteria and yeast induced arachidonate release and these studies bring forward that SFK has a pivotal role in acting proximally of several known members of the …
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A gyermek- és fiatalkori bűnözés egyes aspektusai
… megemlítem a hatályos szabályozást és a Btk. várható módosításait. A nemzetközi kitekintés során más országok helyzetét is bemutatom a fiatalkori bűnözés mértéke alapján, illetve hazai statisztikákat is bemutatok. Kiemelkedő pontja a dolgozatnak a büntethetőségi korhatár …
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Novel approaches to assess cellular interactions and their role in the pathology and treatment of lymphoproliferative disorders
… machinery, such as Bruton’s tyrosine kinase (BTK), disrupt the migratory behaviour of CLL cells, and that this may, at least in part, underlie their clinical effect. Detailed characterisation of the highly dynamic cytoskeletal alterations in CLL may, therefore, inform novel therapeutic …
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B Cell Receptor Signalng in Germinal Centers
… I developed a Bruton's tyrosine kinase (BTK) drug-resistant mouse model. I found that continuous BCR engagement was necessary for the survival of light zone B cells and that survival was intrinsic to BCR signaling by inhibiting BTK. Lastly, I investigated the synergy between BCR signaling …
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Therapeutic Vulnerabilities of Venetoclax Resistant Chronic Lymphocytic Leukemia and Novel Treatment Strategies Targeting BCL2/BCL-XL
… relapsed on Bruton’s tyrosine kinase inhibitors (BTKi). The broad hypothesis of this thesis is that VEN-relapsed CLL exhibits altered dependence on BCL2 family members, which can be exploited for therapeutic benefit. I profiled 28 CLL samples collected from 15 patients either at baseline or at …
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CD40 stimulation activates ‘post-activated’ B Cells which are hyporesponsive to B Cell receptor and toll-like receptor 9 stimulation in autoimmunity
… of the kinases Syk, Bruton’s tyrosine kinase (Btk) and protein kinase B (Akt). This was supplemented by data on protein tyrosine phosphatase (PTP) and protein serine/threonine phosphatase (PSP) activities and recruitment of the PTP Src homology region 2 (SH2) domain-containing phosphatase-1 …
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Targeting Epigenetic Regulators For The Treatment of Diffuse Large B-Cell Lymphoma
… Combination therapy with SYK, PI3Kdelta and BTK kinase inhibitors was highly synergistic in multiple lymphoma cell lines, regardless of EZH2 mutation status. At the epigenetic level, prolonged treatment with EPZ-6438 increased global levels of Histone H4 Arginine-3 asymmetric di-methylation. …
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The Role of Foxo Transcription Factors in B Cell Development and Activation
… expression. This is via activation of the PI3K/Btk/BLNK/PLC-gamma2 pathway. Conversely, Foxo mRNA expression is upregulated in immature B cells, both when the tonic/basal signal through the BCR is disrupted and when the BCR is engaged with anti-IgM. Overexpression of Foxo3 mRNA in an immature B …
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